[1]姜志锋,许建强,孙永东,等.难治性精神分裂症的外科治疗进展[J].中国临床神经外科杂志,2024,29(09):561-564569.[doi:10.13798/j.issn.1009-153X.2024.09.012]
　JIANG Zhi-feng,XU Jian-qiang,SUN Yong-dong,et al.Progress of surgical treatment for refractory schizophrenia[J].,2024,29(09):561-564569.[doi:10.13798/j.issn.1009-153X.2024.09.012]
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难治性精神分裂症的外科治疗进展()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
29
期数:
2024年09期
页码:
561-564569
栏目:
综述
出版日期:
2024-09-30

文章信息/Info

Title:
Progress of surgical treatment for refractory schizophrenia
文章编号:
1009-153X（2024）09-0561-04
作者:
姜志锋; 许建强; 孙永东; 王黎华; 刘辉
056200 河北，邯郸市中西医结合医院神经外科（姜志锋）；056200 河北邯郸，华北医疗健康集团峰峰总医院神经外科（姜志锋、许建强、孙永东、王黎华、刘　辉）
Author(s):
JIANG Zhi-feng1; 2;  XU Jian-qiang2;  SUN Yong-dong2;  WANG Li-hua2;  LIU Hui2
1. Department of Neurosurgery, Handan Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Handan 056200, China; 2. Department of Neurosurgery, North China Medical and Health Group Fengfeng General Hospital, Handan 056200, China
关键词:
难治性精神分裂症; 外科治疗; 神经回路影像
Keywords:
Refractory schizophrenia;  Neurocircuit imaging;  Surgical treatment
分类号:
R 749.3; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2024.09.012
文献标志码:
A
摘要:
精神分裂症是一种慢性、高致残性精神疾病，临床表现为思维、情感及行为紊乱和认知功能障碍。我国精神分裂症的患病率接近1%，其中20%~30%的病人最终发展为难治性精神分裂症。难治性精神分裂症对常规抗精神病药物治疗反应不佳，一直是临床的难点。随着神经外科技术的发展，难治性精神分裂症可以考虑手术干预，如立体定向局灶性毁损术、深部脑刺激术（DBS）。随着对脑神经回路理解的加深，以及现代立体定向技术和神经影像技术的发展，能以更加微创和精准的方式进行靶点毁损，尤其DBS的发展，使神经外科对精神疾病的治疗越来越受到重视。本文对近年来难治性精神分裂症的神经回路影像研究和外科治疗进展进行综述，为难治性精神分裂症的综合治疗提供帮助。
Abstract:
Schizophrenia is a chronic and severely debilitating psychiatric disorder characterized by disturbances in thought, emotion, behavior, and cognitive function. The prevalence of schizophrenia in China is approximately 1%, with estimates indicating that 20%~30% of patients may eventually develop refractory schizophrenia. Refractory schizophrenia exhibits suboptimal responsiveness to conventional antipsychotic medications, posing significant clinical challenges. Advances in neurosurgical techniques have led to the consideration of surgical interventions for refractory schizophrenia, including stereotactic focal lesioning and deep brain stimulation (DBS). As our understanding of cerebral neural circuits deepens and modern stereotactic and neuroimaging technologies advance, neurosurgical approaches for refractory schizophrenia have garnered increased attention. These methods now enable more minimally invasive and precise target lesioning. Particularly, the development of DBS has significantly enhanced the potential of neurosurgery in treating mental disorders. This review aims to summarize recent advancements in neurocircuit imaging research and neurosurgical treatments for refractory schizophrenia, providing insights for comprehensive management strategies for refractory schizophrenia.

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备注/Memo

备注/Memo:
（2022-08-08收稿，2024-02-28修回）
基金项目：邯郸市科学技术研究与发展计划项目（19422083012-3）
更新日期/Last Update: 2024-09-30