颅-鼻-眶非霍奇金B细胞淋巴瘤1例-《中国临床神经外科杂志》

文章信息/Info

Title:: Cranial-nasal-orbital extranodal marginal zone B-cell lymphoma：a case report

作者:: 柏明涛; 刘海涛; 牛纪杰; 庄须伟; 李晓龙; 张玉海; 100039山东，日照市人民医院神经外科（柏明涛、刘海涛、牛纪杰、庄须伟、李晓龙、张玉海）

Author(s):: BO Ming-tao; LIU Hai-tao; NIU Ji-jie; ZHUANG Xu-wei; LI Xiao-long; ZHANG Yu-hai; Depatment of Neurosurgery, People's Hospital of Rizhao, Rizhao 100039, China

Keywords:: Cranio-nasal-orbital tumors; Non-Hodgkin's lymphoma; Treatment; Prognosis

摘要:: 颅-鼻-眶非霍奇金淋巴瘤为原发性中枢神经系统淋巴瘤，属结外非霍奇金淋巴瘤的一种，临床罕见，约占所有颅内恶性肿瘤1.6%，占结外淋巴瘤的1%~2%。该病恶性程度极高，手术旨在明确病理及减轻肿瘤占位效应，主要以放化疗为主，但总体预后较差。本文报道1例颅-鼻-眶非霍奇金B细胞淋巴瘤，66岁女性，行手术活检，术后病理证实为非霍奇金B细胞淋巴瘤，术后随访1个月死亡。总之，颅-鼻-眶非霍奇金大B细胞淋巴瘤临床较少见，多被误诊为鼻咽癌、眼眶肿瘤及球后视神经炎等，多数行病理检查可得到明确诊断。该病恶性程度极高，单纯依靠手术并不能明显延长生存期，主要以放化疗为主，有利于局部病灶的控制，但总体预后较差。所以正确早期诊断该病非常重要。

Abstract:: Cranio-nasal-orbital non-Hodgkin's lymphoma, as a form of primary central nervous system lymphoma and a subtype of extranodal non-Hodgkin's lymphoma, is clinically rare, accounting for approximately 1.6% of all intracranial malignant tumors and 1%~2% of extranodal lymphomas. The malignancy of this disease is extremely high. The aim of surgery is to clarify the pathology and alleviate the space-occupying effect of the tumor. The main treatment modalities are radiotherapy and chemotherapy, yet the overall prognosis is unfavorable. This paper presents a case of cranio-nasal-orbital non-Hodgkin's B-cell lymphoma in a 66-year-old female. A surgical biopsy was performed, and the postoperative pathology confirmed non-Hodgkin's B-cell lymphoma. The patient died one month after the surgery. In conclusion, cranio-nasal-orbital non-Hodgkin's large B-cell lymphoma is relatively rare in clinical settings and is often misdiagnosed as nasopharyngeal carcinoma, orbital tumors, or retrobulbar optic neuritis, among others. A clear diagnosis can mostly be achieved through pathological examinations. The malignancy of this disease is extremely high. Relying solely on surgery does not significantly prolong the survival period. The main treatments are radiotherapy and chemotherapy, which are conducive to the control of local lesions, but the overall prognosis is poor. Hence, accurate and early diagnosis of this disease is of paramount importance.