[1]孙君昭、张剑宁、任文庆、李庆岗、于　新、赵虎林、李　杰、沈春彩.伽玛刀治疗颈静脉球瘤24例临床分析[J].中国临床神经外科杂志,2020,(09):581-583.[doi:10.13798/j.issn.1009-153X.2020.09.002]
　SUN Jun-zhao,ZHANG Jian-ning,REN Wen-qing,et al.Gamma knife surgery for patients with jugular paragangliomas: report of 24 cases[J].,2020,(09):581-583.[doi:10.13798/j.issn.1009-153X.2020.09.002]
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伽玛刀治疗颈静脉球瘤24例临床分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年09期
页码:
581-583
栏目:
论著
出版日期:
2020-09-20

文章信息/Info

Title:
Gamma knife surgery for patients with jugular paragangliomas: report of 24 cases
文章编号:
1009-153X（2020）09-0581-03
作者:
孙君昭、张剑宁、任文庆、李庆岗、于　新、赵虎林、李　杰、沈春彩
100048 北京，解放军总医院第一医学中心神经外科医学部（孙君昭、张剑宁、任文庆、李庆岗、于　新、赵虎林、李　杰、沈春彩）
Author(s):
SUN Jun-zhao;  ZHANG Jian-ning;  REN Wen-qing;  LI Qing-gang;  YU Xin;  ZHAO Hu-lin;  LI Jie;  SHEN Chun-cai.
Division of Neurosurgery, The First Medical Center of PLA General Hospital, Beijing 100039, China
关键词:
颈静脉球瘤; 伽玛刀治疗; 疗效
Keywords:
Jugular paraganglioma;  Gamma knife surgery;  Outcome
分类号:
A
DOI:
10.13798/j.issn.1009-153X.2020.09.002
文献标志码:
R 739.41; R 730.55
摘要:
目的 探讨伽玛刀治疗颈静脉球瘤的效果。方法 回顾性分析1998年10月至2017年10月应用伽玛刀治疗的24例术后残留或复发的颈静脉球瘤的临床资料。肿瘤体积3.8~19.8 cm3，平均8.26 cm3。照射剂量：肿瘤周边剂量12~16 Gy，平均14.7 Gy；覆盖肿瘤的等剂量曲线为45%~50%，平均48.7%。结果 伽玛刀治疗后随访24~252个月，平均96个月。伽玛刀后5、10年的实际总生存率分别为100%、90.9%。影像随访显示伽玛刀后肿瘤基本消失2例（8.3%），肿瘤体积缩小13例（54.2%），肿瘤稳定8例（33.3%），体积增大1例（4.2%）；肿瘤总控制率为95.8%（23/24）。治疗后症状明显好转或消失7例（29.2%），无变化15例（54.2%），加重2例（8.3%）。结论 伽玛刀治疗术后残留或复发的颈静脉球瘤安全有效，可长期控制肿瘤生长
Abstract:
Objective To evaluate the radiological and clinical outcomes of gamma knife surgery (GKS) for patients with jugular paragangliomas. Methods The clinical data of 24 patients with jugular paragangliomas were analyzed retrospectively. The mean tumor volume was 8.26 cm3 (range, 3.8~19.8 cm3). The mean tumor peripheral dose was 14.7 Gy (range, 12~16 Gy). The mean isodose curve was 48.7% (range, 45%~50%). The median clinical and radiological follow-up period was 96 months (range, 24~252 months). Results The overall five- and ten-year survival rate were 100% and 90.9%, respectively. The tumors were almost disappeared in 2 patients (8.3%), and the volue of tumor was shrank in 13 (54.2%), stable in 8 patients (33.3%), and enlarged in 1 patients (4.2%) who underwent surgical resection 75 months after GKS. The rate of tumor growth control was 95.8% (23/24). The neurological function was improved in 7 patients (29.2%), stable in 15 patients (62.5%), and worsened in 2 patients (8.3%). Conclusion For patients with residual or recurrent jugular paragangliomas after resection, GKS is a safe, effective and minimally invasive tretament option and can result in durable long-term control of the tumor growth

参考文献/References:

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备注/Memo

备注/Memo:
（2020-08-04收稿，2020-8-13修回）通讯作者：赵曰圆，E-mail：303228280@qq.com 马廉亭，E-mail：mlt1937@163.com
更新日期/Last Update: 2020-09-20