[1]李琳琳 喻 明 崔文娟 徐 磊 庞洪波 张运伟.血清miR-122-5p水平与短暂性脑缺血发作病人预后的关 系[J].中国临床神经外科杂志,2020,(10):686-688.[doi:10.13798/j.issn.1009-153X.2020.10.009]
 LI Lin-lin,YU Ming,CUI Wen-juan,et al.Relationship between serum miR-122-5p level and prognosis of patients with transient ischemic attack[J].,2020,(10):686-688.[doi:10.13798/j.issn.1009-153X.2020.10.009]
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血清miR-122-5p水平与短暂性脑缺血发作病人预后的关 系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年10期
页码:
686-688
栏目:
论著
出版日期:
2020-10-25

文章信息/Info

Title:
Relationship between serum miR-122-5p level and prognosis of patients with transient ischemic attack
文章编号:
1009-153X(2020)10-0686-03
作者:
李琳琳 喻 明 崔文娟 徐 磊 庞洪波 张运伟
629000 四川,遂宁市中心医院神经内科(李琳琳、崔文娟、徐 磊、庞洪波、张运伟);563003 贵州,遵义医学院临床医学系神经病学教研室(喻 明)
Author(s):
LI Lin-lin1 YU Ming2 CUI Wen-juan1 XU Lei1 PANG Hong-bo1 ZHANG Yun-wei1.
1. Department of Neurology, Suining Central Hospital, Suining 629000, China; 2. Department of Neurology, Department of Clinical Medicine, Zunyi Medical College,Zunyi 563003, China
关键词:
短暂性脑缺血发作ABCD2评分miR-122-5p预后
Keywords:
Transient ischemic attacks miR-122-5p ABCD2 score Prognosis
分类号:
R 743; Q 786
DOI:
10.13798/j.issn.1009-153X.2020.10.009
文献标志码:
A
摘要:
目的 探讨短暂性脑缺血发作(TIA)病人血清miR-122-5p水平变化及其在病人预后评估中的作用。方法 选取2013年1月至2016年1月收治的TIA病人150例,采集空腹静脉血检测血清miR-122-5p水平。根据入院ABCD2评分分为高危、中危、低危组。以发病90 d内发生脑梗死或死亡、与症状相关的大动脉狭窄≥50%或心源性栓子需要抗凝治疗为主要结局衡量终点事件。结果 150例中,低危组49例,中危组71例,高危组20例。150例中,41例(27.33%)出现终点事件,其中脑梗死10例,死亡1例,大动脉狭窄≥50%有21例,心源性血栓需抗凝治疗9例;其余109例(72.67%)无终点事件情况发生。血清miR-122-5p水平与病人ABCD2评分呈正相关(r=0.784,P<0.05)。发生终点事件TIA病人血清miR-122-5p明显高于无终点事件病人(P<0.05),其中症状相关的大动脉狭窄≥50%病人、脑卒中/死亡病人血清miR-122-5p水平均明显增高(P<0.05),而心源性栓子需抗凝治疗病人血清miR-122-5p水平无明显变化(P>0.05)。多因素logistic回归分析结果显示,血清miR-122-5p水平增高是TIA病人发生终点事件的独立危险因素(P<0.05)。结论 TIA病人血清miR-122-5p水平与ABCD2评分呈正相关;血清miR-122-5p水平增高提示TIA病人预后不良。
Abstract:
Objective To explore the change of serum miR-122-5p level in patients with transient ischemic attack (TIA) and its role in the evaluation of patients’ prognosis. Methods The serum level of miR-122-5p was detected in 150 patients with TIA who were admitted to our hospital from January 2013 to January 2016 by real-time quantitative PCR. The patients were divided into low, medium and high risk groups according to ABCD2 score at admittion. The primary endpoint included: cerebral infarction or death, symptom-related large artery stenosis ≥50%, or cardiogenic embolus requiring anticoagulation therapy within 90 days of onset. Results Of 150 patients, 49 patients were in low-risk group, 71 in medium-risk group, and 20 in high-risk group. Of 150 patients, 41 patients (27.33%) had an end-point event, including 10 patients with cerebral infarction, 1 death, 21 with aortic stenosis ≥50%, and 9 with cardiogenic thrombosis requiring anticoagulation. The serum miR-122-5p level was significantly positively correlated with the ABCD2 score (r=0.784, P<0.05). The serum level of miR-122-5p in patients with end-point event was significantly higher than that in patients with no end-point event (P<0.05). Multivariate logistic regression analysis showed that increased serum miR-122-5p level was an independent risk factor for the end-point event in TIA patients (P<0.05). Conclusions Serum miR-122-5p level in TIA patients is positively correlated with the ABCD2 score. The increase in serum miR-122-5p level indicates poor prognosis of TIA patients.

参考文献/References:

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备注/Memo

备注/Memo:
2019-12-26收稿,2020-08-24修回
通讯作者:张运伟,E-mail:86231457@qq.com
更新日期/Last Update: 2020-10-20