[1]安　鹏　周敏杰　邹冬冬　鲁友明.血清骨桥蛋白在高血压性基底节区出血发病90 d预后评估中的价值[J].中国临床神经外科杂志,2020,(11):756-758.[doi:doi:10.13798/j.issn.1009-153X.2020.11.007]
　AN Peng,ZHOU Min-jie,ZOU Dong-dong,et al.Value of serum osteopontin in predicting 90-day prognoses of patients with acute cerebral hemorrhage[J].,2020,(11):756-758.[doi:doi:10.13798/j.issn.1009-153X.2020.11.007]
点击复制

血清骨桥蛋白在高血压性基底节区出血发病90 d预后评估中的价值()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年11期
页码:
756-758
栏目:
论著
出版日期:
2020-11-25

文章信息/Info

Title:
Value of serum osteopontin in predicting 90-day prognoses of patients with acute cerebral hemorrhage
文章编号:
1009-153X（2020）11-0756-03
作者:
安　鹏　周敏杰　邹冬冬　鲁友明
201306，上海市第六人民医院东院神经外科（安　鹏、周敏杰、邹冬冬、鲁友明）
Author(s):
AN Peng;  ZHOU Min-jie;  ZOU Dong-dong;  LU You-ming.
Department of Neurosurgery, East Hospital of Shanghai Sixth People’s Hospital, Shanghai 201306, China
关键词:
高血压性基底节区出血; 骨桥蛋白; 血清; 预后
Keywords:
Hypertensive basal ganglia hemorrhage;  Serum level;  Osteopontin;  Prognosis
分类号:
R 743.34; Q 786
DOI:
doi:10.13798/j.issn.1009-153X.2020.11.007
文献标志码:
A
摘要:
目的 探讨血清骨桥蛋白（OPN）在高血压性基底节区出血病人发病90 d预后评估中的价值。方法 选取2016年6月至2019年1月收治的高血压性基底节区出血160例和健康体检者100例（对照组），采用酶联免疫吸附试验检测血清OPN水平。发病90 d，用改良Rankin量表评分评估预后，0~2分为预后良好，3~5分预后不良。结果 160例中，预后不良78例，预后良好82例。脑出血病人血清OPN浓度[（7.98±0.12）ng/ml]明显高于对照组[（5.23±0.13）ng/ml；P<0.01]。多因素logistic回归分析显示，血清OPN水平≥7.58 ng/ml是脑出血发病90 d预后不良的独立危险因素（P<0.05）。ROC曲线分析结果显示，血清OPN水平预测脑出血发病90 d预后的曲线下面积为0.813，95%置信区间为0.743~0.868，当截断值为7.58 ng/ml时，预测不良预后的灵敏度为85.9%，特异度为65.8%。结论 高血压性基底节区出血病人血清OPN明显增高，对发病90 d预后评估有一定价值。
Abstract:
Objective To explore the value of serum osteopontin (OPN) in the prognostic evaluation of patients with hypertensive basal ganglia hemorrhage (HBGH) at 90 days. Methods Serum OPN levels were detected in 160 patients with HBGH and 100 healthy subjects (control group) from June 2016 to January 2019 by enzyme-linked immunosorbent assay. At 90 days, the prognosis was evaluated by the modified Rankin scale (mRS) score, with good prognosis of mRS score 0~2 and poor prognosis of mRS score 3~5. Results Of 160 patients with HBGH, 78 patienst had poor prognoses and 82 had good prognoses. The serum OPN lvele of patients with HBGH [(7.98±0.12)ng/ml] was significantly higher than that of the control group [(5.23±0.13) ng/ml; P<0.01]. Multivariate logistic regression analysis showed that serum OPN level ≥7.58 ng/ml was an independent risk factor for poor prognoses of patients with HBGH at 90 days (P<0.05). ROC curve analysis showed that the area under the curve for serum OPN level ≥7.58 ng/ml to predict the poor prognoses of patients with HBGH at 90 days was 0.813 (95% CI 0.743~0.868), and the sensitivity and specificity were 85.9% and 65.8%, respectively. Conclusion The serum OPN of patients with HBGH is significantly increased, which has a certain value for the prognosis evaluation at 90 days.

参考文献/References:

[1] Ma X, Cheng Y, Garcia R, et al. Hemorrhage associated mechanisms of neuroinflammation in experimental traumaticbrain injury[J]. J Neuroimmune Pharmacol, 2019, 26: 1-9.
[2] Gong L, Manaenko A, Fan R, et al. Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage [J]. Neuropharmacology, 2018, 138: 160-169.
[3] Zhu Q, Luo X, Zhang J, et al. Osteopontin as a potential the-rapeutic target for ischemic stroke [J]. Curr Drug Deliv, 2017, 14(6): 766-772.
[4] Li JM, Zhang C. Value of serum OPN levels in patients with acute cerebral hemorrhage for assessment of nerve function impairment[J]. JAD, 2016, 5(3): 222-226.
[5] 中华医学会神经病学分会，中华医学会神经病学分会脑血管病学组. 中国脑出血诊治指南(2014)[J]. 中华神经科杂志，2015，48（6）：435-444.
[6] James ML, Langefeld CD, Sekar P, et al. Assessment of the interaction of age and sex on 90-day outcome after intra-cerebral hemorrhage [J]. Neurology, 2017, 89: 1011-1019.
[7] 官　念，吴碧华， 刘黎明，等. 脑出血病因及相关机制的研究进展[J]. 中华老年心脑血管病杂志， 2016， 18（6）：670-672.
[8] Abid KA, Sobowale OA, Parkes LM, et al. Assessing inflam-mation in acute intracerebral hemorrhage with PK11195 PET and dynamic contrast-enhanced MRI [J]. J Neuro-imaging, 2018, 28(2): 158-161.
[9] Icer MA, Gezmen-Karadag M. The multiple functions and mechanisms of osteopontin [J]. Clin Biochem, 2018, 59: 17-24.
[10] Yan YP, Lang BT, Vemuganti R, et al. Persistent migration of neuroblasts from the subventricular zone to the injured striatum mediated by osteopontin following intracerebral hemorrhage [J]. J Neurochem, 2009, 109(6): 1624-1635.
[11] Sun C, Enkhjargal B, Reis C. Osteopontin-enhanced auto-phagy attenuates early brain injury via FAK-ERK pathway and improves long-term outcome after subarachnoid hemo-rrhage in rats [J]. Cells, 2019, 8(9): 980-988.
[12] Gao N, Zhang-Brotzge X, Wali B, et al. Plasma osteopontin may predict neuroinflammation and the severity of pediatric traumatic brain injury [J]. J Cereb Blood Flow Metab, 2020, 40(1): 35-43.

相似文献/References:

[1]苏　里　赵志军　梅小龙　杨建华　包文平　张春阳.调控人骨桥蛋白的miRNA预测研究[J].中国临床神经外科杂志,2016,(04):210.[doi:10.13798/j.issn.1009-153X.2016.04.006]
　SU Li,ZHAO Zhi-jun,MEI Xiao-lun,et al.Study of the prediction of microRNA regulating human osteopontin[J].,2016,(11):210.[doi:10.13798/j.issn.1009-153X.2016.04.006]
[2]张颜礼汪丽珍孟建红等.CTP在高血压性基底节区小量出血治疗方案评估中的价值[J].中国临床神经外科杂志,2017,(01):23.[doi:10.13798/j.issn.1009-153X.2017.01.008]
　ZHANG Yan-li,WANG Li-zhen,MENG Jian-hong,et al.Value of CTP in evaluation of treatment of hypertensive basal ganglion hemorrhage[J].,2017,(11):23.[doi:10.13798/j.issn.1009-153X.2017.01.008]
[3]王立江,王久忠,成立峰,等.小骨窗开颅血肿清除术治疗高血压性基底节区出血[J].中国临床神经外科杂志,2017,(02):83.[doi:10.13798/j.issn.1009-153X.2017.02.007]
　WANG Li-jiang,WANG Jiu-zhong,CHENG Li-feng,et al.Treatment of hypertensive basal ganglia hemorrhage by small bone window craniotomy[J].,2017,(11):83.[doi:10.13798/j.issn.1009-153X.2017.02.007]
[4]郑杨睿　余新光　孙正辉　张家墅　尹一恒.神经内镜手术与显微手术治疗高血压性基底节区出血的疗效对比分析[J].中国临床神经外科杂志,2018,(04):243.[doi:10.13798/j.issn.1009-153X.2018.04.007]
　ZHENG Yang-rui,YU Xin-guang,SUN Zheng-hui,et al.Comparison of clinical effects on intracerebral hemorrhage in basal ganglia: endoscopic neurosurgery vs. microneurosurgery[J].,2018,(11):243.[doi:10.13798/j.issn.1009-153X.2018.04.007]
[5]马 俊,周 勇,马元施,等.经外侧裂-岛叶入路显微手术治疗高血压性基底节区出血的疗效分析[J].中国临床神经外科杂志,2018,(09):613.[doi:10.13798/j.issn.1009-153X.2018.09.013]
[6]王巧玲　万盛楠　孙成梅　王海萍.高血压性基底节区出血围手术期应激性高血糖与 预后的关系[J].中国临床神经外科杂志,2018,(12):806.[doi:10.13798/j.issn.1009-153X.2018.12.015]
[7]李　智　闫　聪　赵洪波.高血压性基底节区出血个体化手术治疗[J].中国临床神经外科杂志,2020,(09):618.[doi:10.13798/j.issn.1009-153X.2020.09.013]
[8]吴少帅　徐福林　马　捷　杜嘉瑞　苏作鹏.颅内压监测在高血压性基底节区出血治疗中的应用[J].中国临床神经外科杂志,2021,26(01):41.[doi:10.13798/j.issn.1009-153X.2021.01.014]
[9]王　璨　黄锦峰　喻军华.神经内镜手术治疗高血压性基底节区出血28例[J].中国临床神经外科杂志,2021,26(02):129.[doi:10.13798/j.issn.1009-153X.2021.02.023]
[10]岳盛魁,潘东红,刘浩波,等.高血压性脑出血穿刺引流术后并发张力性血肿9例[J].中国临床神经外科杂志,2023,28(01):41.[doi:10.13798/j.issn.1009-153X.2023.01.012]

更新日期/Last Update: 2020-11-25