[1]郭 松 任志伟 胡永生等.单纯影像定位与微电极辅助定位在帕金森病手术中的应用[J].中国临床神经外科杂志,2021,26(03):149-152.[doi:10.13798/j.issn.1009-153X.2021.03.002]
 GUO Song,REN Zhi-wei,HU Yong-sheng,et al.Simple imaging-guided versus microelectrode recording-guided deep brain stimulaton for patients with Parkinson’s disease[J].,2021,26(03):149-152.[doi:10.13798/j.issn.1009-153X.2021.03.002]
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单纯影像定位与微电极辅助定位在帕金森病手术中的应用()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年03期
页码:
149-152
栏目:
论著
出版日期:
2021-03-25

文章信息/Info

Title:
Simple imaging-guided versus microelectrode recording-guided deep brain stimulaton for patients with Parkinson’s disease
文章编号:
1009-153X(2021)03-0149-04
作者:
郭 松 任志伟 胡永生等
100053 北京,首都医科大学宣武医院功能神经外科/北京市功能神经外科研究所(郭 松、任志伟、胡永生、庄 平、李建宇)
Author(s):
GUO Song REN Zhi-wei HU Yong-sheng et al
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
关键词:
帕金森病丘脑底核脑深部电刺激术微电极记录影像学定位
Keywords:
Parkinson’s disease Subthalamic nucleus Deep brain stimulation Microelectrode recording
分类号:
R 742.5; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2021.03.002
文献标志码:
A
摘要:
目的 比较单纯影像定位与微电极辅助定位(MER)进行丘脑底核脑深部电刺激术(STN-DBS)治疗帕金森病(PD)的疗效。方法 回顾性分析2017年1月至2019年12月STN-DBS治疗的112例PD的临床资料。70例通过单纯影像定位(影像组),42例通过MER辅助定位(MER组)。术前与术后3个月,进行“关”状态下统一帕金森病评定量表(UPDRS)运动部分(Ⅲ)评分评估疗效,症状改善率=(术前评分-术后评分)/术前评分×100%。结果 影像组手术时间[(125±17)min]较MER组[(158±23)min]明显缩短(P<0.05)。两组电极尖端位置、术后3个月刺激参数(电压、频率、脉宽)均无统计学差异(P>0.05)。与术前药物“关”状态基线数据相比,术后3个月药物“关”状态DBS开启时,两组运动功能评分无统计学差异(P>0.05)。影像组运动功能评分改善率(56.3%)、震颤症状改善改善率(79.5%)、僵直症状改善率(57.9%)、运动迟缓评分改善率(44.8%)与MER组(分别为56.4%、75.4%、60.9%、47.6%)均无统计学差异(P>0.05)。两组术后均未发生出血及感染。结论 对于 STN-DBS治疗PD,单纯影像学定位与MER辅助定位技术对脑深部电极埋置位置和运动症状改善无明显差异,但是单纯影像定位技术可以缩短手术时间。
Abstract:
Objective To compare the clinical efficay of simple imaging (SI)-guided versus microelectrode recording (MER)-guided subthalamic nucleus deep brain stimulation (STN-DBS) for the patients with Parkinson’s disease (PD). Methods The clinical data of 112 PD patients who undewent STN-DBS from January 2017 to December 2019 were analyzed retrospectively. Of 112 patients, 70 received SI-guided STN-DBS (SI group) and 42 received MER-Guided STN-DBS (MER group). The clinical efficacy was assessed by unified Parkinson Disease Scale (III) Score before and 3 months after the surgery, with symptom improvement rate as: (preoperative score-postoperative score)/preoperative score×100%. Results The operation time in SI group [(125±17)min] was significantly shorter than that [(158±23)min] in MER group (P<0.05). There was no significant difference in the position of electrode, and stimulating parameters and symptom improvement rate 3 months after the operation between the two groups (P>0.05). There was no psotoperative bleeding and infection in both groups. Conclusions For the PD patients receiving STN-DBS, there were no significant differences in the clinical motor outcomes and positions of electrodes between the two techniques, but the SI positioning technique can shorten the operation time.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者:李建宇,E-mail:lijianyu@vip.sohu.com
更新日期/Last Update: 2021-03-25