[1]左争辉　屈洪彬　李治晓　王甲光　马春晓.巨细胞胶质母细胞瘤的临床诊治分析（附9例报道）[J].中国临床神经外科杂志,2021,26(05):327-329.[doi:10.13798/j.issn.1009-153X.2021.05.003]
　ZUO Zheng-hui,QU Hong-bin,LI Zhi-xiao,et al.Analysis of clinical diagnosis and treatment of giant cell glioblastoma：report of 9 cases[J].,2021,26(05):327-329.[doi:10.13798/j.issn.1009-153X.2021.05.003]
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巨细胞胶质母细胞瘤的临床诊治分析（附9例报道）()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年05期
页码:
327-329
栏目:
论著
出版日期:
2021-05-25

文章信息/Info

Title:
Analysis of clinical diagnosis and treatment of giant cell glioblastoma：report of 9 cases
文章编号:
1009-153X（2021）05-0327-03
作者:
左争辉　屈洪彬　李治晓　王甲光　马春晓
450003 郑州，河南大学人民医院神经外科（左争辉、李治晓、王甲光、马春晓）；450004 郑州，郑州市第一人民医院神经外科（屈洪彬）
Author(s):
ZUO Zheng-hui1;  QU Hong-bin2;  LI Zhi-xiao1;  WANG Jiag-uang1;  MA Chun-xiao1.
1. Department of Neurosurgery, People’s Hospital of Henan University, Zhengzhou 450003, China; 2. Department of Neurosurgery, First People’s Hospital of Zhengzhou City, Zhengzhou 450004, China
关键词:
巨细胞胶质母细胞瘤; 临床特点; 治疗; 预后
Keywords:
Giant cell glioblastoma;  Clinical characteristics;  Treatment;  Prognosis
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2021.05.003
文献标志码:
A
摘要:
目的 探讨巨细胞胶质母细胞瘤（GCG）的临床特点、治疗及预后。方法 回顾性分析2014年5月至2020年9月收治的经术后病理确诊的9例GCG的临床资料。9例均行开颅手术治疗，术后1个月进行放疗，同期口服替莫唑胺化疗。结果 9例肿瘤全切除，术后病理均为GCG（WHO分级Ⅳ级）。9例术后随访1~5年，其中5例病情稳定，GOS评分4分；复发4例，GOS评分3分；术后15、18个月各死亡1例。结论 目前，GCG主要采用手术联合术后放、化疗的综合治疗，但是总体预后不佳，复发率及病死率较高。
Abstract:
Objective To analyze the clinical features, treatment and prognosis of giant cell glioblastoma (GCG). Methods The clinical data of 9 patients with GCG who underwent microsurgery from May 2014 to September 2020 were retrospectively analyzed. Results Total tumor resection was achieved in all the patients. The postoperative pathological findings showed GCG in all the patients (WHO grade Ⅳ). All the patients reveived postoperative radiotherapy and concurrent temozolomide chemotherapy. The follow-up (1~5 years) showed stable condition in 5 patients with a GOS score of 4, recurrence in 2 patients with a GOS score of 3 and death in 2 patients (died 15 and 18 months after the operation, respectively). Conclusions At present, GCG patients are mainly treated with surgery combined with postoperative radiotherapy and concurrent temozolomide chemotherapy. However, the overall prognoses of GCG patients are very poor, and the rates of tumor recurrence and patient mortality are high.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：河南省医学科技攻关计划省部共建项目（SB201901082）
通讯作者：马春晓，E-mail:chxma@126.com
更新日期/Last Update: 2021-05-25