[1]陈科宇　江普查.瘤周水肿与人脑高级别胶质瘤预后的相关性[J].中国临床神经外科杂志,2021,26(05):352-353.[doi:10.13798/j.issn.1009-153X.2021.05.011]
　CHEN Ke-yu,JIANG Pu-cha..Correlation between peritumoral edema of high-grade glioma and patients’ prognoses[J].,2021,26(05):352-353.[doi:10.13798/j.issn.1009-153X.2021.05.011]
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瘤周水肿与人脑高级别胶质瘤预后的相关性()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年05期
页码:
352-353
栏目:
论著
出版日期:
2021-05-25

文章信息/Info

Title:
Correlation between peritumoral edema of high-grade glioma and patients’ prognoses
文章编号:
1009-153X（2021）05-0352-02
作者:
陈科宇　江普查
430071 武汉，武汉大学第二临床学院（陈科宇）；430071 武汉，武汉大学中南医院神经外科（江普查）
Author(s):
CHEN Ke-yu1;  JIANG Pu-cha2.
1. The Second Clinical College of Wuhan University, Wuhan 430071, China; 2. Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
关键词:
高级别胶质瘤; 瘤周水肿; 预后
Keywords:
High-grade glioma;  Peritumoral edema;  Prognosis
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2021.05.011
文献标志码:
A
摘要:
目的 探讨术前MRI显示的瘤周水肿特征与幕上高级别胶质瘤病人预后的相关性。方法 回顾性分析2017年1月至2019年3月手术治疗的、经术后病理证实的105例幕上高级别胶质瘤的临床资料。根据术前MRI评估瘤周水肿程度。随访截止时间为2020年6月。105例术后随访6~36个月，平均17个月。生存期是指从初次手术到死亡或末次随访的时间。结果 105例中，轻度瘤周水肿42例，重度63例。105例病人中位生存期为15个月。多因素Cox回归分析结果显示，术前MRI显示重度瘤周水肿是高级别胶质瘤生存预后不良的独立危险因素（P<0.05）。生存曲线分析结果显示，重度瘤周水肿病人中位生存时间（14.0个月）较轻度瘤周水肿病人（30.0个月）明显缩短（P<0.001）。结论 术前常规MRI显示的严重瘤周水肿与幕上高级别胶质瘤病人生存预后密切相关，瘤周水肿越严重，病人预后越差。
Abstract:
Objective To explore the correlation between the peritumoral edema before surgery and the prognoses of patients with supratentorial high-grade glioma. Methods The clinical data of 105 patients with supratentorial high-grade glioma who underwent surgery from January 2017 to March 2019 were retrospectively analyzed. The imaging characteristics of peritumoral edema were evaluated by preoperative MRI. The follow-up deadline was June 2020. The followed up ranged fro 6 months to 36 months, with an average of 17 months. Survival time was difined as the time from initial surgery to death or last follow-up. Results Of 105 patients, mild peritumoral edema occurred in 42 patients, severe in 63. The median survival time of 105 patients was 15 months. Multivariate Cox regression analysis showed that severe peritumoral edema was an independent risk factor for poor survival prognosis of high grade glioma patients (P<0.05). Survival curve analysis showed that the median survival time (14.0 months) of patients with severe peritumoral edema was significantly shorter than that (30.0 months) of patients with mild peritumoral edema (P<0.001). Conclusions Peritumoral edema is closely related to the survival prognosis of patients with supratentorial high grade glioma. The more severe the peritumoral edema, the worse the prognosis of the patient with supratentorial high grade glioma.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：江普查，E-mail：jiangpucha64@163.com
更新日期/Last Update: 2021-05-25