[1]王 超 丰育功.HIF-1α及其下游基因VEGF-A和MMP-9在血管源性脑水肿中的作用机制[J].中国临床神经外科杂志,2021,26(09):732-734.[doi:10.13798/j.issn.1009-153X.2021.09.028]
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HIF-1α及其下游基因VEGF-A和MMP-9在血管源性脑水肿中的作用机制()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年09期
页码:
732-734
栏目:
综述
出版日期:
2021-09-25

文章信息/Info

文章编号:
1009-153X(2021)09-0732-03
作者:
王 超 丰育功
266000 山东青岛,青岛大学附属医院神经外科(王 超、丰育功)
关键词:
血管源性脑水肿缺氧诱导因子1-α血管内皮生长因子-A基质金属蛋白酶-9
分类号:
R 742; Q 786
DOI:
10.13798/j.issn.1009-153X.2021.09.028
文献标志码:
A

参考文献/References:

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[3] Singh A, Wilson JW, Schofield CJ, et al. Hypoxia-inducible factor (hif) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model [J]. Sci Rep, 2020, 10(1): 1597.
[4] Benita Y, Kikuchi H, Smith AD, et al. An integrative geno-mics approach identifies hypoxia inducible factor-1 (hif-1)-target genes that form the core response to hypoxia [J]. Nucleic Acids Res, 2009, 37(14): 4587-4602.
[5] Liu FJ, Kaur P, Karolina DS, et al. Mir-335 regulates hif-1 alpha to reduce cell death in both mouse cell line and rat ischemic models [J]. PLoS One, 2015, 10(6): e0128432.
[6] Yeh SH, Ou LC, Gean PW, et al. Selective inhibition ofearly--but not late--expressed hif-1alpha is neuroprotec-tive in rats after focal ischemic brain damage [J]. Brain Pathol, 2011, 21(3): 249-262.
[7] Vangeison G, Carr D, Federoff HJ, et al. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes [J]. J Neurosci, 2008, 28(8): 1988-1993.
[8] Singh N, Sharma G, Mishra V. Hypoxia inducible factor-1: its potential role in cerebral ischemia [J]. Cell Mol Neuro-biol, 2012, 32(4): 491-507.
[9] Geiseler SJ, Morland C. The janus face of vegf in stroke [J]. Int J Mol Sci, 2018, 19(5): 1362.
[10] Zhang ZG, Zhang L, Jiang Q, et al. Vegf enhances angioge-nesis and promotes blood-brain barrier leakage in the ischemic brain [J]. J Clin Invest, 2000, 106(7): 829-838.
[11] Yang GL, Zhao Z, Qin TT, et al. Tnfsf15 inhibits vegf-stimulated vascular hyperpermeability by inducing vegfr2 dephosphorylation [J]. FASEB J, 2017, 31(5): 2001-2012.
[12] Misra S, Montaner J, Ramiro L, et al. Blood biomarkers for the diagnosis and differentiation of stroke: a systematic review and meta-analysis [J]. Int J Stroke, 2020, 15(7): 704-721.
[13] Turner RJ, Sharp FR. Implications of mmp9 for blood brain barrier disruption and hemorrhagic transformation following ischemic stroke [J]. Front Cell Neurosci, 2016, 10(56): 1-13.
[14] Gu Z, Cui J, Brown S, et al. A highly specific inhibitor ofmatrix metalloproteinase-9 rescues laminin from proteoly-sis and neurons from apoptosis in transient focal cerebral ischemia [J]. J Neurosci, 2005, 25(27): 6401-6408.
[15] Zhao BQ, Wang S, Kim HY, et al. Role of matrix metallo-proteinases in delayed cortical responses after stroke [J]. Nat Med, 2006, 12(4): 441-445.
[16] Zan L, Zhang X, Xi Y, et al. Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion [J]. Neuroscience, 2014, 262: 118-128.
[17] Higashida T, Kreipke CW, Rafols JA, et al. The role ofhypoxia-inducible factor-1alpha, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury [J]. J Neurosurg, 2011, 114(1): 92-101.
[18] Zhang HT, Zhang P, Gao Y, et al. Early vegf inhibitionattenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of mmps [J]. Mol Med Rep, 2017, 15(1): 57-64.
[19] Won S, Lee JH, Wali B, et al. Progesterone attenuateshemorrhagic transformation after delayed tpa treatment in an experimental model of stroke in rats: involvement of the vegf-mmp pathway [J]. J Cereb Blood Flow Metab, 2014, 34(1): 72-80.

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81870914)
通讯作者:丰育功,E-mail:fengyugongqdu@163.com
更新日期/Last Update: 1900-01-01