[1]胡平,叶立果,陈谦学.脑胶质瘤IDH基因突变的分子机制及其相关靶向治疗的研究进展[J].中国临床神经外科杂志,2022,27(05):405-406.[doi:10.13798/j.issn.1009-153X.2022.05.024]
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脑胶质瘤IDH基因突变的分子机制及其相关靶向治疗的研究进展()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年05期
页码:
405-406
栏目:
综述
出版日期:
2022-05-31

文章信息/Info

文章编号:
1009-153X(2022)05-0405-02
作者:
胡平叶立果陈谦学
430060武汉,武汉大学人民医院神经外科(胡平、叶立果、陈谦学)
关键词:
脑胶质瘤IDH靶向治疗
分类号:
R39.41;Q786
DOI:
10.13798/j.issn.1009-153X.2022.05.024
文献标志码:
A

参考文献/References:

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[2] álvarez de Eulate-Beramendi S, álvarez-Vega MA, Balbin M, et al. Prognostic factors and survival study in high-grade glioma in the elderly [J]. Br J Neurosurg, 2016, 30(3): 330- 336.
[3] Juratli TA, Kirsch M, Robel K, et al. IDH mutations as an early and consistent marker in low-grade astrocytomas WHO grade II and their consecutive secondary high-grade gliomas [J]. J Neuro-oncol, 2012, 108(3): 403-410.
[4] Louis DN, Perry A, Reifenberger G, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary [J]. Acta Neuropathol, 2016, 131(6): 803-820.
[5] 王修成,王新军,曾凡涛. IDH-1在胶质瘤中的表达及相 关因素分析[J]. 中国实用神经疾病杂志,2018,21(22): 2450-2455.
[6] 茆晨雪,周宏灏,刘昭前. 弥漫性胶质瘤生物标志物的发 现及研究进展[J]. 中国临床药理学与治疗学,2016,21 (1):93-98.
[7] Reiter-Brennan C, Semmler L, Klein A. The effects of 2- hydroxyglutarate on the tumorigenesis of gliomas [J]. Con- temp Oncol (Pozn), 2018, 22(4): 215-222.
[8] Sun C, Zhao Y, Shi J, et al. Isocitrate dehydrogenase1 muta- tion reduces the pericyte coverage of microvessels in astro- cytic tumours [J]. J Neuro-oncol, 2019, 143(2): 187-196.
[9] Mohme M, Schliffke S, Maire CL, et al. Immunophenotyping of newly diagnosed and recurrent glioblastoma defines distinct immune exhaustion profiles in peripheral and tumor-infiltrating lymphocytes [J]. Clin Cancer Res, 2018, 24(17): 4187-4200.
[10] Waitkus MS, Diplas BH, Yan H. Isocitrate dehydrogenase mutations in gliomas [J]. Neuro-oncol, 2016, 18(1): 16-26.
[11] Fan J, Kamphorst JJ, Rabinowitz JD, et al. Fatty acid label- ing from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux [J]. J Biol Chem, 2013, 288(43): 31363-31369.
[12] Li F, He X, Ye D, et al. NADP(+)-IDH mutations promote hypersuccinylation that impairs mitochondria respiration and induces apoptosis resistance [J]. Mol Cell, 2015, 60(4): 661-675.
[13] Seltzer MJ, Bennett BD, Joshi AD, et al. Inhibition of gluta- minase preferentially slows growth of glioma cells with mutant IDH1 [J]. Cancer Res, 2010, 70(22): 8981-8987.
[14] Fujii T, Khawaja MR, DiNardo CD, et al. Targeting isoci- trate dehydrogenase (IDH) in cancer [J]. Discov Med, 2016, 21(117): 373-380.
[15] Schumacher T, Bunse L, Pusch S, et al. A vaccine targeting mutant IDH1 induces antitumour immunity [J]. Nature, 2014, 512(7514): 324-327.
[16] Weenink BAS, van Brakel Mandy, Wijers REBECCA, et al. Lack of B and T cell reactivity towards IDH1R132H in blood and tumor tissue from LGG patients [J]. J Neuro- oncol, 2019, 144(1): 79-87.
[17] Rashidian J, Copaciu R, Su Q, et al. Generation and perfor- mance of R132H mutant IDH1 rabbit monoclonal antibody [J]. Antibodies (Basel), 2017, 6(4): 22.
[18] Rohle D, Popovici-Muller J, Palaskas N, et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells [J]. Science, 2013, 340(6132): 626-630.
[19] Stein EM, DiNardo CD, Pollyea DA, et al. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia [J]. Blood, 2017, 130(6): 722-731.
[20] Konteatis Z, Artin E, Nicolay B, et al. Vorasidenib (AG- 881): a first-in-class, brain-penetrant dual inhibitor of mutant IDH1 and 2 for treatment of glioma [J]. ACS Med Chem Lett, 2020, 11(2): 101-107.

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备注/Memo

备注/Memo:
通讯作者:陈谦学,E-mial:chenqx666@whu.edu.cn
更新日期/Last Update: 2022-06-30