[1]姚自同,赵文可,黄昌恒,等.颅内前后循环症状性动脉粥样硬化性狭窄血管内治疗的Meta分析[J].中国临床神经外科杂志,2018,(10):665-669.[doi:10.13798/j.issn.1009-153X.2018.10.008]
　YAO Zi-tong,ZHAO Wen-ke,HUANG Chang-heng,et al.Meta-analysis of the effect of aggressive medical treatment and endovascular interventional therapy on symptomatic intracranial atherosclerotic stenosis in anterior and posterior circulations[J].,2018,(10):665-669.[doi:10.13798/j.issn.1009-153X.2018.10.008]
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颅内前后循环症状性动脉粥样硬化性狭窄血管内治疗的Meta分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年10期
页码:
665-669
栏目:
论著
出版日期:
2018-10-25

文章信息/Info

Title:
Meta-analysis of the effect of aggressive medical treatment and endovascular interventional therapy on symptomatic intracranial atherosclerotic stenosis in anterior and posterior circulations
文章编号:
1009-153X（2018）10-0665-05
作者:
姚自同; 赵文可; 黄昌恒; 何一川; 魏孟广; 裴美娟; 于耀宇
300162 天津，武警后勤学院附属医院神经外科脑血管病中心（姚自同、赵文可、黄昌恒、何一川、魏孟广、裴美娟、于耀宇）
Author(s):
YAO Zi-tong;  ZHAO Wen-ke;  HUANG Chang-heng;  HE Yi-chuan;  WEI Meng-guang;  PEI Mei-juan;  YU Yao-yu.
Department of Neurosurgery, The Affiliated Hospital, Logistics University, People’s Armed Police Force, Tianjin 300162, China
关键词:
颅内动脉狭窄; 粥样硬化; 血管内治疗; 强化内科治疗; Meta分析
Keywords:
Intracranial atherosclerosis;  Stenosis;  Endovascular interventional treatment;  Aggressive medical treatment;  Meta-analysis
分类号:
R 743; R 815.2
DOI:
10.13798/j.issn.1009-153X.2018.10.008
文献标志码:
A
摘要:
目的 系统评价强化内科治疗（AMT）联合血管内介入治疗（EIT）对颅内前后循环症状性动脉粥样硬化性狭窄（sICAS）的疗效和安全性。方法 计算机检索PubMed、Cochrane Library、Embase等数据库，纳入AMT与AMT联合EIT对sICAS有效性和安全性的随机对照试验，结局指标包括30 d内和远期（≥12月）的卒中、短暂性脑缺血发作（TIA）或死亡。采用RevMan 5.3软件进行Meta分析。结果 共纳入9项随机对照试验，共993例sICAS。Meta分析显示：无论是前循环，还是后循环，两组30 d主要终点事件（P>0.05）、远期卒中（P>0.05）、远期TIA（P>0.05）风险均无显著性差异。结论 在目前情况下，不论颅内前循环还是后循环sICAS，不推荐EIT作为初始治疗方法；对于AMT无效以及严重sICAS合并侧支循环形成不良的病人，可考虑EIT；对于个体化定制EIT与最佳药物治疗，尚需要进一步研究。
Abstract:
Objective To assess effect of aggressive medical treatment (AMT) plus endovascular intervention treatment (EIT) on symptomatic intracranial atherosclerotic stenosis (sICAS) in the different parts of the anterior and posterior circulations and their safety. Methods The databases including PubMed, Cochrane Library and EMbase were searched for the randomized controlled trials of the effects of AMT and AMT plus EIT on sICAS and their safety. The RevMan 5.3 software was used for the meta-analysis of the obtained data. Results Nine randomized controlled trials which were obtained included 993 patients. The meta-analysis showed that there were insignificant differences in primary endpoint events 30 days after the treatment, long-term stroke and transient ischemia attack rates between the AMT and AMT plus EIT groups in the patients with anterior and posterior circulations sICAS (P>0.05). Conclusions The efficacy and risk of AMT plus EIT are insignificantly different from those of AMT in the patients with anterior and posterior circulations sICAS.

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备注/Memo

备注/Memo:
通讯作者：于耀宇，E-mail：yuyaoyu666@aliyun.com
更新日期/Last Update: 2018-09-30