[1]熊　平　唐晓平　张　涛.颅内神经内分泌癌6例报道及文献复习[J].中国临床神经外科杂志,2019,(03):135-137.[doi:10.13798/j.issn.1009-153X.2019.03.003]
　XIONG Ping,TANG Xiao- ping,ZHANG Tao..Intracranial neuroendocrine carcinoma: report of 6 cases and review of the literature[J].,2019,(03):135-137.[doi:10.13798/j.issn.1009-153X.2019.03.003]
点击复制

颅内神经内分泌癌6例报道及文献复习()

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年03期
页码:
135-137
栏目:
论著
出版日期:
2019-03-20

文章信息/Info

Title:
Intracranial neuroendocrine carcinoma: report of 6 cases and review of the literature
文章编号:
1009-153X（2019）03-0135-03
作者:
熊　平　唐晓平　张　涛
作者单位：637000 四川南充，川北医学院附属医院神经外科（熊　平、唐晓平、张　涛）
Author(s):
XIONG Ping;  TANG Xiao- ping;  ZHANG Tao.
Department of Neurosurgery, Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, China
关键词:
颅内神经内分泌癌; 显微手术; 伽玛刀
Keywords:
Intracranial neuroendocrine carcinoma;  Diagnosis;  Treatment;  Surgery
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2019.03.003
文献标志码:
A
摘要:
目的 探讨颅内神经内分泌癌的临床表现、影像学特征、病理学表现、治疗方法及其效果。方法 回顾性分析2000~2018年收治的6例颅内神经内分泌癌的临床资料。结果 肿瘤位于左侧顶枕叶及第四脑室内1例、右侧顶叶1例、右侧额叶3例、小脑半球1例。4例发现肺部占位。术前均误诊为胶质瘤。6例均手术全切肿瘤，术后病检结果示神经内分泌癌。5例术后随访1周至12个月，1例术后未行放、化疗，3个月死亡；4例术后伽玛刀治，1例6个月死亡，3例随访12个月生活基本自理。1例失访。结论 颅内神经内分泌癌是一种极其罕见的疾病，恶性程度高，临床表现和影像学特征不明显，术前诊断较为困难，病理学是诊断的金标准，主要以手术切除为主辅以放、化疗的综合治疗。
Abstract:
Objective To investigate the clinical manifestations, imaging features and pathological features of intracranial neuroendocrine carcinoma in order to improve the diagnosis and treatment of this disease. Methods The clinical data of 6 patients (age, 23~65 years; gender, 4 males and 2 females) with intracranial neuroendocrine carcinomas who were treated in our hospital from 2000 to 2018 were retrospectively analyzed. Of 6 carinomas, 1 was in the left parietal occipital lobe and the fourth ventricle, 1 in the right parietal lobe, 3 in the right frontal lobe and 1 in the cerebellar hemisphere. The space-occupying lesions were found also in the lungs of 4 patients. The surgical resection of the carinomas was performed on all the patients. The carcinomas were preoperatively misdiagnosed as gliomas in all the patients. All the neuroendocrine carcinomas were definitely made by pathological examination. Results Five patients were followed up from 1 week to 12 months after the surgery. One patient with metastatic tumor undergoing postoperative gamma knife treatment died 6 months after the surgery. One patient who did not receive further postoperative radiotherapy and chemotherapy died 3 months after the surgery. Three patients receiving the postoperative gamma knife therapy still survived 12 months after the surgery. One patient lost to be followed up. Conclusions The intracranial neuroendocrine carcinoma is a rare, and highly malignant tumor and the primary intracranial neuroendocrine carcinoma is more rare. Its diagnosis is difficult according to its clinical manifestations and imaging features. The histopathological manifestations are the gold standard of its diagnosis. The surgery and postoperative radiochemotherapy is a main method to treat the carcinoma.

参考文献/References:


[1] Faggianno A, Mansueto G, Ferolla P, et al. Diagnosis and prognostic implication of the world hesalth organization classification of neu-roendoerinet tumors [J]. J Endocrinol Invest, 2008, 31(3): 216-223.
[2] Matula C, Roessler K, Burian M, et al. Primary Neuroendo-crine (Merkel Cell) carcinoma of the anterior skull base [J]. Skull Base Surg, 1997, 7(3): 151-158.
[3] Hood B, Bray E, Bregy A, et al. Primary carcinoid tumor of the cavernous sinus [J]. World Neurosurg, 2014, 81(1): 209-213
[4] Nakaguchi H, Matsuno A, Miyawaki S, et al. Small cell car-cinoma originating from the cavernous sinus [J]. Acta Neu-rochir (Wien), 2010, 152(3): 493-500.
[5] Khagi S, Saif MV. Neuroendocrine tumors, treatment updates[J]. J Pancreas, 2013, 14(4): 367-371.
[6] Ragab Shalaby AM, Kazuei H, Koichi H, et al. Assessment of intracranial metastases from neuroendocrine tumors/carcinoma [J]. J Neurosci Rural Pract, 2016, 7(3): 435-439.
[7] Nakaguchi H, Matsuno A, Miyawaki S, et al. Small cell car-cinoma originating from the cavernous sinus [J]. Acta Neu-rochir (Wien), 2010, 152(3): 493-500.
[8] Porter DG, Chakrabarty A, McEvoy A, et al. Intracranial carcinoid without evidence of extracranial disease [J]. Neu-ropathol Appl Neurobiol, 2000, 26(3): 298-300.
[9] 李　旭，高芳友，蒋伟峰. 小脑半球囊实性神经内分泌癌1例报告并文献复习[J]. 贵州医药，2013，37（12）：1130-1132
[10] Boedeker CC, Neumann HP, Ridder GJ, et al. Paraganglio-masin patients with mutations of the SDHD gene [J]. Otola-ryngol Head Neck Surg, 2005, 132(3): 467-470.
[11] Cao J, Xu W, Du Z, et al. Pathologic progression, possible origin, and management of multiple primary intracranial neuroendocrine carcinomas [J]. World Neurosurg, 2017, 106: 13-17.
[12] Lach B, Joshi SS, Murty N, et al. Transformation of Merkel cell carcinomto ganglioneuroblastoma in intracranial metas-tasis [J]. Hum Pathol, 2014, 45(9): 1978-1981.
[13] Sopranzi A, Santucci N, Bolognini A, et al. Neuroendocrine carcinoma of the colon with metastasis to the brain: a case report and review of the literature [J]. Chir Ital, 2005, 2(1): 115-120.
[14] Franco P1, Numico G, Migliaccio F, et al. Head and neck region consolidation radiotherapy and prophylactic cranial irradiation with hippocampal avoidance delivered with helical tomotherapy after induction chemotherapy for non-sinonasal neuroendocrine carcinoma of the upper airways [J]. Radiat Oncol, 2012, 15: 7-21.
[15] Akimoto J, Fukuhara H, Suda T, et al. Clinicopathological analysis in patients with neuroendocrine tumors that metas-tasized to the brain [J]. BMC Cancer, 2016, 22: 16-36.
[16] D'Antonio C, Passaro A, Gori B, et al. Bone and brain meta-stasis in lung cancer: Recent advances in therapeutic strategies [J]. Ther Adv Med Oncol, 2014, 6: 101-104.

相似文献/References:

[1]林国中　王振宇　马长城　赵　薇.神经电生理监测下显微手术切除脊髓髓内肿瘤[J].中国临床神经外科杂志,2015,(11):647.[doi:10.13798/j.issn.1009-153X.2015.11.003]
　LIN Guo-zhong,WANG Zhen-yu,MA Chang-cheng,et al.Clinical value of intraoperative electrophysiological monitoring to microsurgery for intramedullary spinal tumors[J].,2015,(03):647.[doi:10.13798/j.issn.1009-153X.2015.11.003]
[2]谢京城　王振宇　陈晓东.骶管终丝脊膜囊肿合并脊髓拴系综合征的诊断和治疗[J].中国临床神经外科杂志,2015,(11):651.[doi:10.13798/j.issn.1009-153X.2015.11.004]
　XIE Jing-cheng,WANG Zhen-yu,CHEN Xiao-dong.Diagnosis and surgical treatment of sacral spinal meningeal cysts of fila terminale complicated with tethered spinal cord syndrome[J].,2015,(03):651.[doi:10.13798/j.issn.1009-153X.2015.11.004]
[3]于　涛　黄正通　王振宇.椎管内脊膜囊肿的临床特征和治疗方法[J].中国临床神经外科杂志,2015,(11):654.[doi:10.13798/j.issn.1009-153X.2015.11.005]
　YU Tao,HUANG Zheng-tong,WANG Zhen-yu.Clinical features and treatment of intraspinal arachnoid cysts[J].,2015,(03):654.[doi:10.13798/j.issn.1009-153X.2015.11.005]
[4]谢宝树　王　宇　贾　锋　张　林　殷玉华.神经电生理监测下显微手术治疗成人脊髓栓系综合征[J].中国临床神经外科杂志,2015,(11):658.[doi:10.13798/j.issn.1009-153X.2015.11.006]
　XIE Bao-shu,WANG Yu,JIA Feng,et al.Intraoperative electrophysiological monitoring-guided microsurgery on tethered spinal cord syndrome in adults[J].,2015,(03):658.[doi:10.13798/j.issn.1009-153X.2015.11.006]
[5]赵东升　王正君　孙刚锋　费　舟　姬西团　李　娟　万晓强.椎管内畸胎瘤的诊断与治疗[J].中国临床神经外科杂志,2015,(11):661.[doi:10.13798/j.issn.1009-153X.2015.11.007]
　ZHAO Dong-sheng,WANG Zheng-jun,SUN Gang-feng,et al.Dignosis and treatment of intraspainal teratomas[J].,2015,(03):661.[doi:10.13798/j.issn.1009-153X.2015.11.007]
[6]陈晓东　于　涛　王振宇.脊髓髓内神经鞘瘤的诊断与治疗[J].中国临床神经外科杂志,2015,(11):670.[doi:10.13798/j.issn.1009-153X.2015.11.010]
　CHEN Xiao-dong,YU Tao,WANG Zhen-yu.Diagnosis and treatment of intramedullary spinal schwannomas[J].,2015,(03):670.[doi:10.13798/j.issn.1009-153X.2015.11.010]
[7]马　磊　张海红　张　威　衡立君　孙树凯　贾　栋.眶上锁孔入路手术切除前颅底脑膜瘤的临床效果[J].中国临床神经外科杂志,2015,(11):680.[doi:10.13798/j.issn.1009-153X.2015.11.013]
　MA Lei,ZHANG Hai-hong,ZHANG Wei,et al.Microsurgery through supraorbital keyhole approach for anterior cranial fossa meningiomas[J].,2015,(03):680.[doi:10.13798/j.issn.1009-153X.2015.11.013]
[8]李春坡　郑　军　李海元　边　涛　韩安国.侧脑室三角区小型脑膜瘤的显微外科治疗[J].中国临床神经外科杂志,2015,(11):694.[doi:10.13798/j.issn.1009-153X.2015.11.018]
[9]张兆斯　但　炜　王　刚　周　超　孙　超　谢延风　石全红　詹　彦.咪达唑仑和丙泊酚诱导麻醉对继发性癫痫术中皮层脑电图的影响[J].中国临床神经外科杂志,2016,(05):261.[doi:10.13798/j.issn.1009-153X.2016.05.002]
　ZHANG Zhao-si,DAN Wei,WANG Gang,et al.Effects of midazolam or propofol used for induction of anesthesia on intraoperative ECoG in patients with secondary epilepsy[J].,2016,(03):261.[doi:10.13798/j.issn.1009-153X.2016.05.002]
[10]赵　平　王雄伟　汪　雷　马金阳.显微手术和血管内栓塞术治疗颅内动脉瘤的疗效分析[J].中国临床神经外科杂志,2016,(05):281.[doi:10.13798/j.issn.1009-153X.2016.05.008]
　ZHAO Ping,WANG Xiong-wei,WANG Lei,et al.Effect of endovascular treatment on intracranial aneurysms: a comparison with microsurgery[J].,2016,(03):281.[doi:10.13798/j.issn.1009-153X.2016.05.008]

更新日期/Last Update: 2019-03-25