[1]孙连杰,董　军,高　峰,等.荧光显微镜在颅内恶性肿瘤切除术中的应用[J].中国临床神经外科杂志,2019,(04):197-199.[doi:10.13798/j.issn.1009-153X.2019.04.003]
　SUN Lian-jie,DONG Jun,GAO Feng,et al.Application of fluorescein sodium combined with fluorescence microscope to resection of intracranial malignant tumors[J].,2019,(04):197-199.[doi:10.13798/j.issn.1009-153X.2019.04.003]
点击复制

荧光显微镜在颅内恶性肿瘤切除术中的应用()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年04期
页码:
197-199
栏目:
论著
出版日期:
2019-04-27

文章信息/Info

Title:
Application of fluorescein sodium combined with fluorescence microscope to resection of intracranial malignant tumors
文章编号:
1009-153X（2019）04-0197-03
作者:
孙连杰; 董　军; 高　峰; 李　珂; 张振宇; 张　诚; 麦麦提依明·托合提; 杨小朋
830000 乌鲁木齐，新疆维吾尔自治区人民医院神经外科（孙连杰、董　军、高　峰、李　珂、张　诚、麦麦提依明·托合提、杨小朋）；830000 乌鲁木齐，新疆医科大学（张振宇）
Author(s):
SUN Lian-jie1;  DONG Jun1;  GAO Feng1;  LI Ke1;  ZHANG Zhen-yu2 ZHANG Cheng1;  MAITIYIMING Tohti1;  YANG Xiao-peng1.
1. Department of Neurosurgery, People’s Hospital of Xinjiang Uygur Autonomous region, Urumqi 830000, China; 2. Xinjiang Medical University, Urumqi 830000, China
关键词:
颅内恶性肿瘤; 荧光素钠; 荧光显微镜; 显微手术
Keywords:
Intracranial malignant tumors;  Fluorescein sodium;  Fluorescence microscope;  Neurosurgery
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2019.04.003
文献标志码:
A
摘要:
目的 探讨小剂量荧光素钠（FLS）和560 nm荧光显微镜在切除颅内恶性肿瘤的中应用效果。方法 回顾性分析2016年9月至2018年2月手术治疗的51例颅内恶性肿瘤的临床资料。均在全麻诱导后静脉注射FLS（5 mg/kg），在 560 nm荧光显微镜下判断肿瘤边界指导完成肿瘤切除。结果 51例中，胶质母细胞瘤33例，间变性星形细胞瘤6例，转移瘤4例，间变性少突胶质细胞瘤3例，胶质肉瘤3例，髓母细胞瘤2例。术中荧光均显影，明显提高肿瘤边界的可视化。肿瘤全切除32例，次全切除13例，部分切除6例。51例无任何过敏反应或其他不良反应。术后随访5~16个月，中位随访时间为9.5个月。术后KPS评分提高16例，下降15例，与术前相同20例。结论 应用小剂量FLS联合560 nm荧光显微镜辅助切除颅内恶性肿瘤安全、有效，有助于辨别肿瘤边界，提高肿瘤切除程度。
Abstract:
Objective To explore the technique of low dose fluorescein sodium (FLS) combined with yellow 560 nm fluorescence microscope-assisted neurosurgery for intracranial malignant tumors. Methods Fifty-one patients with intracranial malignant tumors diagnosed before the surgery were treated by low dose FLS combined with yellow 56 nm fluorescence microscope-assisted neurosurgery in the Department of Neurosurgery of Xinjiang Uygur Autonomous Region People’s Hospital from September 2016, to February, 2018. Of 51 patients, 33 had glioblastomas, 6 anaplastic astrocytmas, 4 metastatic tumors, 3 anaplastic oligodendrocytomas, 3 glial sarcomas and 2 medulloblastoma. Results The fluorescence developed and the visualization of tumorous boundary was improved during the operation in all the patients. There were no allergic or other adverse reactions in all the patients. Of 51 patients, 32 received the total resection of the tumors, 13 subtotal and 6 partial. The median Karnofsky performance scale (KPS) score was 80.0 point in these 51 patients after the operation. The KPS score was improved in 16 patients, decreased in 15 and unchanged in 20 after the operation. Conclusion The application of low dose FLS to the neurosurgery is safe and helpful to identification of the tumorous boundary and increase in the extent of tumor resection in the patients with intracranial malignant tumors.

参考文献/References:

[1] 《中国中枢神经系统胶质瘤诊断和治疗指南》编写组. 中 国中枢神经系统胶质瘤诊断与治疗指南（2015）[J]. 中华 医学杂志，2016，96（7）：485-509.
[2] Walter S, Uwe P, Thomas M, et al. Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malig- nant glioma: a randomised controlled multicentre phase Ⅲ trial [J]. Lancet Oncol, 2006, 7(5): 392-401.
[3] Brown TJ, Brennan MC, Li M, et al. Association of the extent of resection with survival in glioblastoma: a systematic review and meta-analysis [J]. JAMA Oncol, 2016, 2(11): 1460-1469.
[4] Nader S, Berger MS. Glioma extent of resection and its impact on patient outcome [J]. Neurosurgery, 2008, 62(4): 753-764.
[5] Schebesch KM, Brawanski A, Hohenberger C, et al. Fluore- scein sodium-guided surgery of malignant brain tumors: history, current concepts, and future project [J]. Turk Neurosurg, 2016, 26(2): 185-189.
[6] Zhang SH, Huang HY, Wu J. Clinical observation of side effects of fluorescein sodium injection in fundus fluorescein angiography [J]. Int J Ophthalmol, 2013, 13(9): 1943-1944.
[7] Acerbi F, Broggi M, Eoli M, et al. Is fluorescein-guided technique able to help in resection of high-grade gliomas [J]. J Neurosurg Focus, 2014, 36(2): 1-8.
[8] Hamamc?oglu MK, Ak?akaya MO, G?ker B, et al. The use of the YELLOW 560 nm surgical microscope filter for sodium fluorescein-guided resection of brain tumors: our prelimi- nary results in a series of 28 patient [J]. Clin Neurol Neuro- surg, 2016, 143: 39-45.
[9] Zhang J, Al-Nahari F, Wang ZF, et al. Application of fluo- rescein sodium in the resection of vermis pilocytic astrocy- tomas [J]. World J Surg Oncol, 2017, 15(1): 46-51.

相似文献/References:

[1]孙连杰　王琳洁　杨小朋.颅内原发性恶性黑色素瘤的诊治进展[J].中国临床神经外科杂志,2020,(04):251.[doi:10.13798/j.issn.1009-153X.2020.04.021]
[2]凌国源 综述,莫立根 审校.荧光素钠术中荧光辅助显微手术切除脑胶质瘤的研究进展[J].中国临床神经外科杂志,2022,27(01):56.[doi:10.13798/j.issn.1009-153X.2022.01.021]

备注/Memo

备注/Memo:
（2018-09-26收稿，2019-01-08修回） 基金项目：新疆维吾尔自治区自然科学基金（2017D01C146）；陈忠平基金会基金项目（CSNO-2016-MSD2016） 通讯作者：杨小朋，E-mail：yxp9972@sina.com
更新日期/Last Update: 2019-04-27