[1]卓胜华　张金本　羊良旺　陈申波　张召腾　李争争　杨　堃.METTL21B在人脑胶质瘤中的表达与临床意义[J].中国临床神经外科杂志,2020,(10):692-695.[doi:10.13798/j.issn.1009-153X.2020.10.011]
　ZHUO Sheng-hua,ZHANG Jin-ben,YANG Liang-wang,et al.Expression and clinical significance of methyltransferase METTL21B in human brain gliomas[J].,2020,(10):692-695.[doi:10.13798/j.issn.1009-153X.2020.10.011]
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METTL21B在人脑胶质瘤中的表达与临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年10期
页码:
692-695
栏目:
论著
出版日期:
2020-10-25

文章信息/Info

Title:
Expression and clinical significance of methyltransferase METTL21B in human brain gliomas
文章编号:
1009-153X（2020）10-0692-04
作者:
卓胜华　张金本　羊良旺　陈申波　张召腾　李争争　杨　堃
570102 海口，海南医学院第一附属医院神经外科（卓胜华、张金本、羊良旺、陈申波、张召腾、李争争、杨　堃）
Author(s):
ZHUO Sheng-hua;  ZHANG Jin-ben;  YANG Liang-wang;  CHEN Shen-bo;  ZHANG Zhao-teng;  LI Zheng-zheng;  YANG Kun.
Department of Neurosurgery, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China
关键词:
脑胶质瘤; 蛋白赖氨酸甲基转移酶; METTL21B; 预后
Keywords:
Glioma;  Protein lysine methyltransferase;  METTL21B;  prognosis
分类号:
R 743; R 651.1+2
DOI:
10.13798/j.issn.1009-153X.2020.10.011
文献标志码:
A
摘要:
目的 探讨脑胶质瘤METTL21B的表达及其与病人预后的关系。方法 采用生物信息学分析方法，运用GEPIA、Oncomine、HPA和CGGA等多个数据库分析METTL21B在脑胶质瘤中的表达及其与病人预后的关系，使用CGGA数据库309个样本分析其表达与临床特征的关系及影响脑胶质瘤的预后因素。在LinkedOmics数据库分析与METTL21B正相关的基因，并使用R编程语言进行GO和KEGG注释。结果 脑胶质瘤METTL21B的mRNA和蛋白表达上调，且高表达病人总生存期和无复发生存期明显缩短。METTL21B高表达是胶质瘤病人预后不良的独立危险因素。结论 METTL21B可能是脑胶质瘤一种新型的重要临床预后生物标志物，METTL21B的表达水平与胶质瘤恶性程度呈正相关，与脑胶质瘤病人生存期呈负相关。
Abstract:
Objective To explore the expression of methyltransferase METTL21B in glioma tissues of patients with glioma and its relationship with patients’ prognoses. Methods Multiple databases such as GEPIA, Oncomine, HPA, and CGGA were used to analyze the expression of METTL21B in glioma tissues and its relationship with clinical prognosis of patienst with glioma. A total of 309 samples from CGGA database were used to analyze the relationship between its expression and clinical features and the prognostic factors of glioma patients. The LinkedOmics database was utilized to analyze genes that are positively related to METL21B, and R programming language was used for GO and KEGG annotations. Results The mRNA and protein expressions of METTL21B were up-regulated in glioma tissues, and its high expression was associated with shorter overall survival and relapse-free survival of patienst with glioma. METTL21B was an independent prognostic factor for patienst with glioma. Conclusions METTL21B may be a new and important clinical prognostic biomarker for patients with glioma. The expression of METTL21B is elevated in the malignant phenotype and is negatively correlated with the survival time of patients with glioma.

参考文献/References:

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备注/Memo

备注/Memo:
2020-08-04收稿，2020-09-04修回
基金项目：海南省重点研发计划项目基金（ZDYF2019129)；海南省研究生创新科研课题基金（Hys2019-312）；国家自然科学基金（82060456）
通讯作者：杨　堃，E-mail：chbyk1379@163.com
更新日期/Last Update: 2020-10-20