[1]王孝安　陈一楠　程传东　计　颖.Geminin表达水平与脑胶质瘤病人预后的关系[J].中国临床神经外科杂志,2021,26(08):600-602.[doi:10.13798/j.issn.1009-153X.2021.08.009]
　WANG Xiao-an,CHEN Yi-nan,CHENG Chuan-dong,et al.Relationship between Geminin expression and survival outcome of glioma patients[J].,2021,26(08):600-602.[doi:10.13798/j.issn.1009-153X.2021.08.009]
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Geminin表达水平与脑胶质瘤病人预后的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年08期
页码:
600-602
栏目:
论著
出版日期:
2021-08-25

文章信息/Info

Title:
Relationship between Geminin expression and survival outcome of glioma patients
文章编号:
1009-153X（2021）08-0600-03
作者:
王孝安　陈一楠　程传东　计　颖
Author(s):
WANG Xiao-an;  CHEN Yi-nan;  CHENG Chuan-dong;  JI Ying.
Department of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China
关键词:
脑胶质瘤; Geminin; 基因表达; 预后
Keywords:
Glioma;  Geminin;  Survival prognosis;  Risk factor
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2021.08.009
文献标志码:
A
摘要:
目的 探讨Geminin表达水平与脑胶质瘤病人预后的关系。方法 收集2014年1月~2017年1月手术切除并经术后病理证实的脑胶质瘤标本90例，以及因颅脑损伤内减压术切除的非肿瘤脑组织50，采用PCR检测Geminin mRNA表达水平。90例脑胶质瘤根据Geminin mRNA表达水平中位数分为高表达组和低表达组。90例胶质瘤病人随访时间截止2020年1月1日或者病人死亡，随访32~55个月，中位随访时间41个月。结果 随访期间，死亡80例，存活10例。脑胶质瘤组织Geminin mRNA表达水平明显高于非肿瘤脑组织（P<0.05）。多因素Cox比例回归风险模型分析结果显示，Geminin mRNA过表达是脑胶质瘤病人死亡的独立危险因素（HR=1.874；95% CI 1.323-2.295；P=0.043）。Kaplan-Meier生存曲线显示，低表达组中位生存期较高表达组明显延长（P<0.05）。结论 脑胶质瘤Geminin呈高表达，是病人生存预后不良的独立危险因素。
Abstract:
Objective To investigate the relationship between the Geminin expression and the survival outcome of patients with glioma. Methods The expression levels of Geminin mRNA were detected using PCR method in glioma tissues obtained from 90 glioma patients who underwent microsurgery from January 2014 to January 2017 and in non-tumor cerebral tissues obtained from 50 patients with traumatic brain injury who underwent decompression. Ninety glioma patients were divided into high expression group and low expression group according to the median level of Geminin mRNA. The follow-up period of 90 glioma patients ended on January 1, 2020 or the patients’ death. The follow-up of 90 glioma patients ranged from 32 months to 55 months, with a median follow-up time of 41 months. Results During the follow-up period, 80 glioma patients died and 10 survived. The expression level of Geminin mRNA in glioma tissues was significantly higher than that in non-tumor cerebral tissues (P<0.05). Multivariate Cox proportional regression risk model analysis showed that high expression of Geminin mRNA was an independent risk factor for the death of patients with glioma (HR=1.874; 95% CI 1.323~2.295; P=0.043). Kaplan-Meier survival curve showed that the median survival of the low expression group was significantly longer than the higher expression group (P<0.05). Conclusions Geminin is highly expressed in glioma, which is an independent risk factor for poor survival prognosis of glioma patients.

参考文献/References:

[1] Kristensen BW, Priesterbach-Ackley LP, Petersen JK, et al. Molecular pathology of tumors of the central nervous system [J]. Ann Oncol, 2019, 30(8): 1265-1278.
[2] Liang SY, Zhou YL, Shu MQ, et al. Regulation of geminin byneuropeptide Y in vascular smooth muscle cell prolifera-tion: a current review [J]. Herz, 2019, 44(8): 712-716.
[3] Arbi M, Pefani DE, Taraviras S, et al. Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis [J]. Chromo-soma, 2018, 127(2): 151-174.
[4] 田　薇，章建国，刘益飞，等. Geminin在胃癌组织中的表达及临床意义[J]. 江苏医药，2017，43（15）：1093-1095.
[5] 田　薇，王　燕，章建国，等. HBO1和Geminin在胶质瘤中的表达及与临床病理特征的关系[J]. 南通大学学报（医学版），2020，40（5）：458-462.
[6] Zybina TG, Zybina EV. Role of cell cycling and polyploidy in placental trophoblast of different mammalian species [J]. Reprod Domest Anim, 2020, 55(8): 895-904.
[7] Vassilev A, DePamphilis ML. Links between DNA replica-tion, stem cells and cancer [J]. Genes (Basel), 2017, 8(2):45.
[8] Patmanidi AL, Tsaniras SC, Karamitros D, et al. Concisereview: Geminin-a tale of two tails: DNA replication and transcriptional/epigenetic regulation in stem cells [J]. Stem Cells, 2017, 35(2): 299-310.
[9] Yasunaga S, Ohno Y, Shirasu N, et al. Role of Geminin in cell fate determination of hematopoietic stem cells (HSCs)[J]. Int J Hematol, 2016, 104(3): 324-329.

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备注/Memo

备注/Memo:
作者单位：230001 合肥，中国科学技术大学附属第一医院（安徽省立医院）神经外科（王孝安、陈一楠、程传东、计　颖）
通讯作者：计　颖，E-mail：24602199@qq.com
更新日期/Last Update: 1900-01-01