[1]胡　荣　赵　武　张亚森　李苑奇.lncRNA-FTX与脑胶质瘤病人预后的相关性分析[J].中国临床神经外科杂志,2021,26(09):679-681.[doi:10.13798/j.issn.1009-153X.2021.09.008]
　HU Rong,ZHAO Wu,ZHANG Ya-sen,et al.Correlation between lncRNA FTX level in glioma tissues and survival prognosis of patients with glioma[J].,2021,26(09):679-681.[doi:10.13798/j.issn.1009-153X.2021.09.008]
点击复制

lncRNA-FTX与脑胶质瘤病人预后的相关性分析()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年09期
页码:
679-681
栏目:
论著
出版日期:
2021-09-25

文章信息/Info

Title:
Correlation between lncRNA FTX level in glioma tissues and survival prognosis of patients with glioma
文章编号:
1009-153X（2021）09-0679-03
作者:
胡　荣　赵　武　张亚森　李苑奇
453000 河南，新乡市第一人民医院神经外科（胡　荣、赵　武、张亚森、李苑奇）
Author(s):
HU Rong;  ZHAO Wu;  ZHANG Ya-sen;  LI Yuan-qi.
Department of Neurosurgery, Xinxiang No.1 People’s Hospital, Xinxiang 453000, China
关键词:
脑胶质瘤; 长链非编码RNA FTX; 预后; 危险因素
Keywords:
Glioma;  Long non-coding RNA FTX;  Prognosis;  Risk factors
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2021.09.008
文献标志码:
A
摘要:
目的 探讨长链非编码RNA（lncRNA）FTX表达水平与脑胶质瘤病人预后的相关性。方法 前瞻性收集2016年1月~2018年1月手术切除的脑胶质瘤88例（46例获得瘤旁组织），采用实时逆转录PCR检测lncRNA FTX表达水平，以脑胶质瘤组织lncRNA FTX表达水平均值为界分为高表达组（n=57）和低表达组（n=31）。术后随访3年，主要观察指标为无进展生存期、总生存期。结果 脑胶质瘤组织lncRNA FTX表达水平[（7.54±2.15）]明显高于瘤旁组织[（2.65±0.69）；P<0.001]。多因素Cox比例回归风险模型分析显示，lncRNA FTX高表达是脑胶质瘤生存预后不良的独立危险因素（RR=1.589；95% CI 1.004~2.515；P=0.048）。生存曲线分析显示，高表达组无进展生存期（15.10个月）和总生存期（20.24个月）较低表达组（分别为18.96和25.53个月）明显缩短（P<0.05）。结论 脑胶质瘤lncRNA FTX呈高表达，与病人不良生存预后有关。
Abstract:
Objective To explore the correlation between the expression level of long non-coding RNA (lncRNA) FTX in glioma tissues and the survival prognosis of patients with glioma. Methods The expression level of lncRNA FTX in glioma tissues obtained from 88 glioma patients who underwent microsurgery from January 2016 to January 2018 and in the tissues adjacent to glioma obtained from 46 glioma patients were detected using PCR, the glioma patients were divided into high expression group (n=57) and low expression group (n=31) based on the mean level of lncRNA FTX in glioma tissues. The patients were followed up for 3 years and the main endpoints were progression free survival and overall survival. Results The expression level of lncRNA FTX in glioma tissues was significantly higher than that in the tissues adjacent to glioma (P<0.05). Multivariate Cox proportional regression risk model analysis showed that high expression of lncRNA FTX was an independent risk factor for poor survival prognosis of glioma patients (RR=1.589; 95% CI 1.004~2.515; P=0.048). Survival curve analysis showed that progression free survival (15.10 months) and overall survival (20.24 months) in the high expression group were significantly shorter than those (18.96 and 25.53 months, respectively) in the lower expression group (P<0.05). Conclusions Human gliomas express high level of lncRNA FTX, which is related to poor survival prognosis.

参考文献/References:

[1] 曾　实，许民辉，徐伦山，等. 脑胶质瘤诊疗的研究进展[J]. 医学综述，2017，23（24）：4835-4839.
[2] 范　凡，冯继锋.长链非编码RNA在肿瘤耐药中的研究进展[J]. 现代肿瘤医学，2018，26（22）：176-181.
[3] 龙翔宇，周　伟，江　波，等. 长链非编码RNA FTX靶向miR-21-3p对肝癌细胞生长侵袭和迁移调控作用[J].中华肿瘤防治杂志，2019，26（17）：1244-1250.
[4] 汪　翔，吴　强，李庆中，等. LncRNA在恶性脑胶质瘤中的研究进展[J]. 中华神经外科疾病研究杂志，2017，16（1）：78-80.
[5] 赵羲和，滕　浩，刘啸白，等. 非编码RNA在人脑胶质瘤中的研究进展[J]. 解剖科学进展，2017，23（2）：197-200.
[6] Bo L, Peng R, Wang Z. Long non-coding RNA Ftx promotes osteosarcoma progression via the epithelial to mesenchymal transition mechanism and is associated with poor prognosis in patients with osteosarcoma [J]. Int J Clin Exp Pathol, 2018, 11(9): 4503-4511.
[7] Yang Y, Zhang J, Chen X, et al. LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression [J]. Gene Ther, 2018, 25(5): 321-330.
[8] Jin S, He J, Zhou Y, et al. LncRNA FTX activates FOXA2 expression to inhibit non-smallell lung cancer proliferation and metastasis [J]. J Cell Mol Med, 2020, 24(8): 4839-4849.
[9] Zhang WG, Bi YK, Li JH, et al. Long noncoding RNA FTX is upregulated in gliomas and promotes proliferation and invasion of glioma cells by negatively regulating miR-342-3p [J]. Lab Invest, 2017, 97(4): 447-457.
[10] He X, Sun F, Guo F, et al. Knockdown of long noncoding RNA FTX Inhibits proliferation, migration, and invasion in renal cell carcinoma cells [J]. Oncol Res, 2016, 25(2): 157-166.

相似文献/References:

[1]付　锴　江普查　宫　睿　王　伟.表达VASH1基因的人脑胶质瘤U-87MG细胞对化疗药物敏感性的变化[J].中国临床神经外科杂志,2016,(01):34.[doi:10.13798/j.issn.1009-153X.2016.01.012]
　FU Kai,JIANG Pu-cha,GONG Rui,et al.Effect of lentiviral vector-mediated VASH1 gene on chemosensitivity of human glioma U-87MG cells[J].,2016,(09):34.[doi:10.13798/j.issn.1009-153X.2016.01.012]
[2]崔焕喜,柳　琛.多模态MRI、神经导航和超声在脑胶质瘤术中的应用[J].中国临床神经外科杂志,2016,(11):721.[doi:10.13798/j.issn.1009-153X.2016.11.027]
[3]闫　珊　徐善才.多学科护理照顾模式对脑胶质瘤术后病人自我护理能力的影响[J].中国临床神经外科杂志,2017,(05):352.[doi:10.13798/j.issn.1009-153X.2017.05.026]
　YAN Shan,XU Shan-cai..Effects of multi-subjects nursing care model on self-care ability in patients with brain glioma after operation[J].,2017,(09):352.[doi:10.13798/j.issn.1009-153X.2017.05.026]
[4]罗似亮　夏之柏.脑胶质瘤病人脑脊液Midkine表达的临床意义[J].中国临床神经外科杂志,2017,(06):416.[doi:10.13798/j.issn.1009-153X.2017.06.017]
　LUO Si-liang,XIA Zhi-bo..Clinical meanings of midkine expression in cerebrospinal fluid of patients with gliomas[J].,2017,(09):416.[doi:10.13798/j.issn.1009-153X.2017.06.017]
[5]呼铁民　褚会松　田　甜　王昆鹏　杨国军　杨立军　王维兴.脑胶质瘤ADAM17与EGFR的表达及临床意义[J].中国临床神经外科杂志,2017,(08):557.[doi:10.13798/j.issn.1009-153X.2017.08.012]
　HU Tie-min,CHU Hui-song,TIAN Tian,et al.Expressions of ADAM17 and EGFR in gliomas tissues and their clinical meanings[J].,2017,(09):557.[doi:10.13798/j.issn.1009-153X.2017.08.012]
[6]汪超甲 综述　王　辉 审校.脑胶质瘤化疗现状及耐药机制的研究进展[J].中国临床神经外科杂志,2017,(11):791.[doi:10.13798/j.issn.1009-153X.2017.11.023]
[7]高剑峰　姚庆和　李晓辉　龙宇波　陈振波.脑胶质瘤miR-9、PPARγ表达水平及临床意义[J].中国临床神经外科杂志,2018,(01):17.[doi:10.13798/j.issn.1009-153X.2018.01.006]
　GAO Jian-feng,YAO Qing-he,LI Xiao-hui,et al.Expressions of miR-9 and PPARγ in human brain gliomas and their clinical meanings[J].,2018,(09):17.[doi:10.13798/j.issn.1009-153X.2018.01.006]
[8]刘　靖　吴立权　黄书岚.聚焦解决模式对脑胶质瘤术后病人自我管理效能感及生命意义的影响[J].中国临床神经外科杂志,2018,(03):208.[doi:10.13798/j.issn.1009-153X.2018.03.025]
　LIU Jing,WU Li-quan,HUANG Shu-lan..Effects of solution focused intervention on self-management efficacy and meanings of life in the patients with gliomas after surgery[J].,2018,(09):208.[doi:10.13798/j.issn.1009-153X.2018.03.025]
[9]刘　炎　杭春华.脑胶质瘤卒中误诊为脑动静脉畸形并出血1例[J].中国临床神经外科杂志,2018,(06):448.[doi:10.13798/j.issn.1009-153X.2018.06.025]
[10]刘东明　胡新华　刘　永　陈　玖　刘宏毅.脑胶质瘤病人静息态默认模式网络研究进展[J].中国临床神经外科杂志,2018,(12):821.[doi:10.13798/j.issn.1009-153X.2018.12.022]

更新日期/Last Update: 1900-01-01