[1]张海军　曹培超　郑占强等.人脑胶质瘤miR-145-5p的表达与病人预后的关系[J].中国临床神经外科杂志,2021,26(12):935-937.[doi:10.13798/j.issn.1009-153X.2021.12.012]
　ZHANG Hai-jun,CAO Pei-chao,ZHENG Zhan-qiang,et al.Expression of miR-145-5p in human glioma tissues and its relationship with glioma patients’ prognoses[J].,2021,26(12):935-937.[doi:10.13798/j.issn.1009-153X.2021.12.012]
点击复制

人脑胶质瘤miR-145-5p的表达与病人预后的关系()
分享到：

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年12期
页码:
935-937
栏目:
论著
出版日期:
2021-12-25

文章信息/Info

Title:
Expression of miR-145-5p in human glioma tissues and its relationship with glioma patients’ prognoses
文章编号:
1009-153X（2021）12-0935-03
作者:
张海军　曹培超　郑占强等
475000 河南，开封市中心医院神经外科（张海军、曹培超、薛长理、梁春东、张圣旭）；450000 郑州，河南省人民医院神经外科（郑占强）
Author(s):
ZHANG Hai-jun1;  CAO Pei-chao1;  ZHENG Zhan-qiang2;  XUE Chang-li1;  LIANG Chun-dong1;  ZHANG Sheng-xu1.
1. Department of Neurosurgery, Kaifeng Central Hospital, Kaifeng 475000, China; 2. Department of Neurosurgery, Henan Provincial People’s Hospital, Zhengzhou 450000, China
关键词:
脑胶质瘤; 微小核糖核酸; miR-145-5p; 危险因素; 生存预后
Keywords:
Glioma;  miR-145-5p;  Risk factors;  Survival prognosis
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2021.12.012
文献标志码:
A
摘要:
目的 探讨人脑胶质瘤微小核糖核酸-145-5p（miR-145-5p）的表达变化及其与病人预后的关系。方法 收集2016年6月~2018年6月手术切除的人脑胶质瘤组织155例和同期颅脑损伤颅内减压术切除的非肿瘤脑组织56例（对照组），采用qRT-PCR法检测miR-145-5p的表达水平。胶质瘤病人术后随访36个月，记录病人生存情况。结果 脑胶质瘤组miR-145-5p相对表达量明显低于对照组（P<0.05）。随访截止时，生存85例，死亡70例。多因素Cox比例回归风险模型分析显示miR-145-5p高表达是胶质瘤病人生存预后不良的独立危险因素（P<0.05）。生存曲线分析显示，miR-145-5p低表达3年累积生存率（54.74%）较高表达组（80.00%）明显降低（P<0.001）。结论 脑胶质瘤miR-145-5p呈低表达，与胶质瘤病人生存预后密切相关。
Abstract:
Objective To explore the expression of microribonucleic acid-145-5p (miR-145-5p) in human glioma tissues and its relationship with the prognoses of glioma patients. Methods The expression levels of miR-145-5p were detected using qRT-PCR method in glioma tissues obtained form 155 glioma patients who underwent microsurgery and in non-tumor cerebral tissues obtained from 56 patients with traumatic brain injury (control group) who underwent decompression from June 2016 to June 2018. The patients with glioma were followed up for 36 months after the operation, and the survival status of the patients was recorded. Results The relative expression level of miR-145-5p in the glioma group was significantly lower than that in the control group (P<0.05). At the end of follow-up, 85 glioma patients survived and 70 died. Multivariate Cox proportional regression risk model analysis showed that high expression of miR-145-5p was an independent risk factor for the poor survival prognoses of patients with glioma (P<0.05). Survival curve analysis showed that the 3-year cumulative survival rate of miR-145-5p low expression group (54.74%) was significantly lower than that (80.00%) of the higher expression group (P<0.001). Conclusions The expression of miR-145-5p in glioma is low, which is closely related to the survival prognosis of patients with glioma.

参考文献/References:

[1] Gutmann DH. The tropism of pleiotrophin: orchestratingglioma brain invasion [J]. Cell, 2017, 170(5): 821-822.
[2] 赵羲和，滕　浩，刘啸白，等. 非编码RNA在人脑胶质瘤中的研究进展[J]. 解剖科学进展，2017，23（2）：197-200.
[3] 张雨薇，张馨月，白立川，等. ceRNA调控miR-145-5p介导肿瘤发生发展的研究进展[J]. 现代肿瘤医学，2020，28（10）：1766-1769.
[4] 刘　臣，李根华，李　想，等. 脑胶质瘤综合治疗的研究进展[J]. 中国微侵袭神经外科杂志，2019，24（4）：42-45.
[5] 李德培，陈忠平. 脑胶质瘤临床诊疗新进展[J]. 国际神经病学神经外科学杂志，2020，47（1）：91-94.
[6] 张志勇，张晋霞，李　林，等. 人脑胶质瘤中miRNA的差异表达与预后关系的Meta分析[J]. 现代肿瘤医学，2017， 25（18）：2897-2900.
[7] 韩铖琛，胡晨浩，杨　帆，等. miRNA-145在脑胶质瘤中的作用[J]. 中国临床神经外科杂志，2017，22（7）：44-46.
[8] 朱　琳，曾庆松，王　续. 微小RNA-145-5p对结肠癌细胞增殖凋亡和FSCN1表达的影响[J]. 临床肿瘤学杂志，2019，24（11）：999-1003.
[9] 曹英海，夏春义，王　刚，等. miR-145在胶质瘤中的表达及其对胶质瘤增殖及侵袭的影响[J]. 解剖科学进展，2016，22（6）：633-636.
[10] Liu S, Gao G, Yan D, et al. Effects of miR-145-5p through NRAS on the cell proliferation, apoptosis, migration, and invasion in melanoma by inhibiting MAPK and PI3K/AKT pathways [J]. Cancer Med, 2017, 6(4): 819-833.
[11] 李新茂，魏志玄，张　婷，等. miR-145联合替莫唑胺对U251胶质瘤细胞恶性行为的影响[J]. 实用医学杂志，2016，32（3）：371-375.
[12] 门颖超，张　蕾，艾　浩. miR-145-5p靶向双特异性磷酸酶6对人子宫内膜癌增殖、迁移、侵袭与凋亡的影响[J].南方医科大学学报，2020，40（1）：61-66.
[13] Mei LL, Wang WJ, Qiu YT, et al. miR-145-5p suppresses tumor cell migration, invasion and epithelial to mesenchy-mal transition by regulating the Sp1/NF-κB signaling path-way in esophageal squamous cell carcinoma [J]. Int J Mol Sci, 2017, 18(9): 1833.

相似文献/References:

[1]付　锴　江普查　宫　睿　王　伟.表达VASH1基因的人脑胶质瘤U-87MG细胞对化疗药物敏感性的变化[J].中国临床神经外科杂志,2016,(01):34.[doi:10.13798/j.issn.1009-153X.2016.01.012]
　FU Kai,JIANG Pu-cha,GONG Rui,et al.Effect of lentiviral vector-mediated VASH1 gene on chemosensitivity of human glioma U-87MG cells[J].,2016,(12):34.[doi:10.13798/j.issn.1009-153X.2016.01.012]
[2]崔焕喜,柳　琛.多模态MRI、神经导航和超声在脑胶质瘤术中的应用[J].中国临床神经外科杂志,2016,(11):721.[doi:10.13798/j.issn.1009-153X.2016.11.027]
[3]闫　珊　徐善才.多学科护理照顾模式对脑胶质瘤术后病人自我护理能力的影响[J].中国临床神经外科杂志,2017,(05):352.[doi:10.13798/j.issn.1009-153X.2017.05.026]
　YAN Shan,XU Shan-cai..Effects of multi-subjects nursing care model on self-care ability in patients with brain glioma after operation[J].,2017,(12):352.[doi:10.13798/j.issn.1009-153X.2017.05.026]
[4]罗似亮　夏之柏.脑胶质瘤病人脑脊液Midkine表达的临床意义[J].中国临床神经外科杂志,2017,(06):416.[doi:10.13798/j.issn.1009-153X.2017.06.017]
　LUO Si-liang,XIA Zhi-bo..Clinical meanings of midkine expression in cerebrospinal fluid of patients with gliomas[J].,2017,(12):416.[doi:10.13798/j.issn.1009-153X.2017.06.017]
[5]呼铁民　褚会松　田　甜　王昆鹏　杨国军　杨立军　王维兴.脑胶质瘤ADAM17与EGFR的表达及临床意义[J].中国临床神经外科杂志,2017,(08):557.[doi:10.13798/j.issn.1009-153X.2017.08.012]
　HU Tie-min,CHU Hui-song,TIAN Tian,et al.Expressions of ADAM17 and EGFR in gliomas tissues and their clinical meanings[J].,2017,(12):557.[doi:10.13798/j.issn.1009-153X.2017.08.012]
[6]汪超甲 综述　王　辉 审校.脑胶质瘤化疗现状及耐药机制的研究进展[J].中国临床神经外科杂志,2017,(11):791.[doi:10.13798/j.issn.1009-153X.2017.11.023]
[7]高剑峰　姚庆和　李晓辉　龙宇波　陈振波.脑胶质瘤miR-9、PPARγ表达水平及临床意义[J].中国临床神经外科杂志,2018,(01):17.[doi:10.13798/j.issn.1009-153X.2018.01.006]
　GAO Jian-feng,YAO Qing-he,LI Xiao-hui,et al.Expressions of miR-9 and PPARγ in human brain gliomas and their clinical meanings[J].,2018,(12):17.[doi:10.13798/j.issn.1009-153X.2018.01.006]
[8]刘　靖　吴立权　黄书岚.聚焦解决模式对脑胶质瘤术后病人自我管理效能感及生命意义的影响[J].中国临床神经外科杂志,2018,(03):208.[doi:10.13798/j.issn.1009-153X.2018.03.025]
　LIU Jing,WU Li-quan,HUANG Shu-lan..Effects of solution focused intervention on self-management efficacy and meanings of life in the patients with gliomas after surgery[J].,2018,(12):208.[doi:10.13798/j.issn.1009-153X.2018.03.025]
[9]刘　炎　杭春华.脑胶质瘤卒中误诊为脑动静脉畸形并出血1例[J].中国临床神经外科杂志,2018,(06):448.[doi:10.13798/j.issn.1009-153X.2018.06.025]
[10]刘东明　胡新华　刘　永　陈　玖　刘宏毅.脑胶质瘤病人静息态默认模式网络研究进展[J].中国临床神经外科杂志,2018,(12):821.[doi:10.13798/j.issn.1009-153X.2018.12.022]

更新日期/Last Update: 1900-01-01