[1]李鹏涛王佳玲王西宪郝轶弘禹文勇云经纬王华一张庭荣.鞍区颗粒细胞瘤的诊治分析：附3例报道并文献复习[J].中国临床神经外科杂志,2022,27(02):104-106.[doi:10.13798/j.issn.1009-153X.2022.02.011]
　LI Peng-tao,WANG Jia-ling,WANG Xi-xian,et al.Diagnosis and treatment of patients with sellar granulosa cell tumor: report of 3 cases and literature review[J].,2022,27(02):104-106.[doi:10.13798/j.issn.1009-153X.2022.02.011]
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鞍区颗粒细胞瘤的诊治分析：附3例报道并文献复习()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年02期
页码:
104-106
栏目:
论著
出版日期:
2022-02-25

文章信息/Info

Title:
Diagnosis and treatment of patients with sellar granulosa cell tumor: report of 3 cases and literature review
文章编号:
1009-153X（2022）02-0104-03
作者:
李鹏涛王佳玲王西宪郝轶弘禹文勇云经纬王华一张庭荣
830054乌鲁木齐，新疆医科大学第一附属医院神经外科（李鹏涛、王佳玲、王西宪、郝轶弘、禹文勇、云经纬、王华一、张庭荣）
Author(s):
LI Peng-tao;  WANG Jia-ling;  WANG Xi-xian;  HAO Yi-hong;  YU Wen-yong;  YUN Jing-wei;  WANG Hua-yi;  ZHANG Ting-rong.
Department of Neurosurgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
关键词:
鞍区颗粒细胞瘤; 临床特征; 显微手术; 经鼻蝶入路神经内镜手术
Keywords:
Sellar granulosa cell tumor;  Clinical feature;  Microsurgery;  Endoscopic transsphenoidal surgery
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2022.02.011
文献标志码:
A
摘要:
目的 探讨鞍区颗粒细胞瘤（GCT）的临床特点、诊断及治疗方法。方法回顾性分析经术后病理检查证实的 3例鞍区 GCT的临床资料，并结合文献进行分析。结果行扩大翼点入路手术 2例，其中肿瘤全切除 1例，次全切除 1例；行经鼻蝶入路神经内镜手术全切除肿瘤 1例。术后症状均改善，术后出现一过性尿崩症 1例，垂体功能减退 1例。3例术后均未行放化疗，随访 18~60个月，未见肿瘤复发或进展。结论鞍区 GCT临床少见。对于鞍区和/或鞍上区病变，CT显示比脑组织略高密度影，MRI显示 T1等信号、T2等信号或低信号、均匀或欠均匀强化，应考虑鞍区 GCT可能，以免误诊，延误治疗。治疗方法优先推荐神经内镜经鼻蝶入路手术，可安全、微创地切除肿瘤。
Abstract:
Objective To explore the clinical features, diagnosis and treatment of the patients with sellar granulosa cell tumor (GCT). Methods The clinical data of 3 patients with sellar GCT who were definitely diagnosed by postoperative pathological examinationwere retrospectively analyzed. The related literatures were reviewed. Results Microsurgery through extended pterional approach wasperformed on 2 patients, of whom 1 patient received total tumor resection and 1 subtotal. Neuroendoscopic surgery through nasalsphenoid approach was performed on 1 patient who received total tumor resection. Preoperative symptoms were improved after theoperation. Transient diabetes insipidus occurred in 1 patients, and hypopituitarism in 1 after the surgery. All the patients did not undergoradiotherapy and chemotherapy. The follow-up (range, 18~60 months) showed no tumor recurrence or progression. Conclusions Sellar GCT is extremely rare. For the lesions in the sellar and/or suprasellar region, the GCT should be considered when their CT images showslightlyhigherdensitiesthan cerebraltissues,and theriMRIimagesshowiso-intensityon T1-and T2-weighted images and uniform ornon-uniform enhancement. For treatment of sellar GCT, neuroendoscopic transnasal sphenoid surgery is preferentially recommended,which can safely and minimally invasively remove the tumors.

参考文献/References:

[1] Kobalka PJ, Huntoon K, Becker AP. Neuropathology ofpituitary adenomas and sellar lesions [J]. Neurosurgery,2021, 88: 900-918.
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[3] Ahmed AK, Dawood HY, Cote DJ, et al. Surgical resectionof granular cell tumor of the sellar region: three indications[J]. Pituitary, 2019, 22: 633-639.
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[8] Orning JL, Trembath DG, Zanation AM, et al. Endoscopicendonasal approach for resection of infundibular granularcell tumor: case report and literature review [J]. J Case RepMed, 2013, 2: 235775.
[9] 刘卫硕，蒋建伟，惠国帧 .神经垂体颗粒细胞瘤的临床病理分析 [J].中华神经外科疾病研究杂志， 2018，17（3）: 224-227.
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[11] Ahmed AK, Dawood HY, Penn DL, et al. Extent of surgicalresection and tumor size predicts prognosis in granular celltumor of the sellar region [J]. Acta Neurochir (Wien), 2017,159: 2209-2216.
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备注/Memo

备注/Memo:
通讯作者：张庭荣，E-mail：zhangtingrong999@sohu.com
更新日期/Last Update: 1900-01-01