[1]卜金鑫,朱海涛,徐宏浩,等.基于脑磁图的高频振荡在难治性癫痫中的研究进展[J].中国临床神经外科杂志,2024,29(08):491-494.[doi:10.13798/j.issn.1009-153X.2024.08.011]
　BU Jin-xin,ZHU Hai-tao,XU Hong-hao,et al.Research advances of high-frequency oscillations based on magnetoencephalography in intractable epilepsy[J].,2024,29(08):491-494.[doi:10.13798/j.issn.1009-153X.2024.08.011]
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基于脑磁图的高频振荡在难治性癫痫中的研究进展()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
29
期数:
2024年08期
页码:
491-494
栏目:
综述
出版日期:
2024-08-30

文章信息/Info

Title:
Research advances of high-frequency oscillations based on magnetoencephalography in intractable epilepsy
文章编号:
1009-153X（2024）08-0491-04
作者:
卜金鑫; 朱海涛; 徐宏浩; 张锐
210029南京，南京医科大学附属脑科医院功能神经外科（卜金鑫、朱海涛、徐宏浩、张锐）
Author(s):
BU Jin-xin;  ZHU Hai-tao;  XU Hong-hao;  ZHANG Rui
Department of Functional Neurosurgery, Brain Hospital Affiliated of Nanjing Medical University, Nanjing 210029, China
关键词:
难治性癫痫; 癫痫灶切除术; 高频振荡; 脑磁图
Keywords:
Drug resistant epilepsy;  High frequency oscillations;  Magnetoencephalogram
分类号:
R 742.1
DOI:
10.13798/j.issn.1009-153X.2024.08.011
文献标志码:
A
摘要:
癫痫是多种原因导致的脑部神经元高度同步化异常放电所致的临床综合征。多数癫痫经药物治疗可得到有效控制，但有一部分癫痫病人对抗癫痫药物治疗反应差，癫痫发作难以控制，称为难治性癫痫。目前，癫痫灶切除术是治疗难治性癫痫的主要手段，切除术成功的关键是准确识别致痫灶。然而，如何准确定位致痫灶一直是神经外科的一项难题。既往，主要通过脑电图中棘波来定位致痫灶。2006年，有学者在局灶性癫痫病人颅内脑电图中记录到高频振荡。近年来，研究表明高频振荡比棘波能更具体地划定致痫灶的界限，可以作为致痫灶新的生理标识。本文主要就基于脑磁图的高频振荡在难治性癫痫中的研究进展进行综述。
Abstract:
Epilepsy is a clinical syndrome resulting from highly synchronized abnormal discharges of neurons caused by multiple factors. Most epilepsy can be effectively controlled through drug treatment; however, a portion of epilepsy patients show a poor response to antiepileptic drug therapy and have difficult-to-control seizures, which are referred to as refractory epilepsy. Currently, epilepsy focus resection is the main treatment method for refractory epilepsy, and the key to a successful resection lies in the accurate identification of the epileptogenic focus. Nevertheless, accurately locating the epileptogenic focus has consistently been a challenge in neurosurgery. Previously, the epileptogenic focus was mainly located through spike waves in the electroencephalogram (EEG). In 2006, high-frequency oscillations was found in the intracranial EEG of patients with focal epilepsy. In recent years, research has indicated that high-frequency oscillations can delineate the boundaries of the epileptogenic focus more specifically than spike waves and can serve as a new physiological marker of the epileptogenic focus. This article primarily reviews the research progress of high-frequency oscillations based on magnetoencephalography in refractory epilepsy.

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备注/Memo

备注/Memo:
（2022-05-14收稿，2024-01-03修回）
通信作者，张　锐，Email：neurosurgeonzr@njmu.edu.cn
更新日期/Last Update: 2024-08-30