[1]钟 宝 陈治标.血清神经元特异性烯醇化酶的含量变化与颅脑损伤程度的关系[J].中国临床神经外科杂志,2015,(08):481-482511.[doi:10.13798/j.issn.1009-153X.2015.08.012]
 ZHONG Bao,CHEN Zhi-biao..Relationship between serum level of neuron specific enolase and degree of severity of brain injury in patients with brain injury[J].,2015,(08):481-482511.[doi:10.13798/j.issn.1009-153X.2015.08.012]
点击复制

血清神经元特异性烯醇化酶的含量变化与颅脑损伤程度的关系()
分享到:

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年08期
页码:
481-482511
栏目:
论著
出版日期:
2015-08-25

文章信息/Info

Title:
Relationship between serum level of neuron specific enolase and degree of severity of brain injury in patients with brain injury
文章编号:
1009-153X(2015)08-0481-02
作者:
钟 宝 陈治标
430060 武汉,武汉大学人民医院神经外科(钟 宝、陈治标)
Author(s):
ZHONG Bao CHEN Zhi-biao.
Department of Neurosurgery, People’s Hospital, Wuhan University, Wuhan 430060, China
关键词:
颅脑损伤严重程度神经元特异性烯醇化酶相关性
Keywords:
Brain injury Neuron specific enolase Severity Relationship
分类号:
R 651.1+5; R44611+2
DOI:
10.13798/j.issn.1009-153X.2015.08.012
文献标志码:
A
摘要:
目的 探讨血清神经元特异性烯醇化酶(NSE)的含量变化与颅脑损伤程度的关系。方法 2012年6月至2013年12月收治颅脑损伤患者254例,根据入院时GCS评分将其分为轻、中、重型三组,分别为82、88、84例;对照组为同期我院正常健康体检者85例。分别于伤后第1、3、5、7 d应用双抗体夹心酶标免疫法检测血清NSE的水平。结果 轻型组患者血清NSE水平与对照组无统计学差异(P>0.05);中型组血清NSE水平明显高于轻型组(P<0.05),重型组明显高于中型组(>P<0.05)。>结论 血清的NSE含量可在一定程度上反映脑组织的损伤程度。
Abstract:
Objective To investigate the relationship between the serum level of neuron specific enolase (NSE) and degree of severity of brain injury in the patients with brain injury. Methods Of 254 patients with brain injury treated in our hospital from June, 2012 to December, 2013, 82 suffered from mild brain injury, 88 from medial brain injury and 84 from severe brain injury according to GCS. The serum levels of NSE were determined by double antibody enzyme-labeled immunoassay in all the patients 1, 3, 5 and 7 days after the injury and 85 health subjects serving as control. Results The serum levels of NSE were significantly higher in the patients with severe brain injury than those in the patients with medial brain injury, which were significantly higher than those in the patients with mild brain injury 1, 3, 5 and 7 days after the injury and in the control group (P<0.05). there="" was="" insignificant="" difference="" in="" the="" serum="" levels="" of="" nse="" between="" patients="" with="" mild="" brain="" injury="" and="" health="" subjects="" (P>0.05). Conclusion It is suggested that the serum NSE level may reflect the degree of severity of brain injury in a certain extent.

参考文献/References:

[1] 魏 伟,田恒力,曹合利,等. 颅脑创伤患者同时监测血清 神经元特异性烯醇化酶及心肌酶的临床意义[J]. 中国现 代医学杂志,2011,21(17):2013-2015,2020.
[2] Mueller K, Sacher J, Arelin K, et al. Overweight and obesity are associated with neuronal injury in the human cere- bellum and hippocampus in young adults: a combined MRI, serum marker and gene expression study [J]. Translational Psychiatry, 2012, 2(4): e200.
[3] 郑 平,童武松. 颅脑损伤后神经递质系统变化与认知障 碍的研究进展[J]. 中华神经医学杂志,2012,11(2):199- 202.
[4] 薄雪峰,刘庆凯,曹海勇,等. 亚低温治疗脑卒中及颅脑损 伤研究进展[J]. 北京生物医学工程,2013,32(4):428- 431,438. (下转第511页) (上接第482页)
[5] 左克俭,马凤鑫,马福兴,等. 血清、脑脊液神经元特异性 烯醇化酶的检测在颅脑外伤中的意义[J]. 青海医药杂 志,2012,42(7):10-12.
[6] 侯博儒,王治民,任海军,等.颅脑损伤后血清神经元特异 性烯醇化酶变化[J]. 中华神经外科疾病研究杂志,2005, 4(2):178-179.
[7] Woertgen C, Rothoerl RD, Wiesmann M, et al. Neuron- specific enolase serum levels after controlled cortical impact injury in the rat [J]. J Neurotrauma, 2001, 18: 569-573.
[8] 陈 兵,龙霄翱,王东军,等. 颅脑损伤患者早期血清 IL-6和NSE的变化及临床意义[J]. 中华神经医学杂志, 2005,4(5):477-478.
[9] 金细众,杨 坤,林芙蓉,等. 急性脑损伤患者血清神经元 特异性烯醇化酶与GCS评分、APACHE Ⅱ评分和疾病风 险系数的相关性[J]. 实用医学杂志,2009,25(12):2000- 2001.
[10] 黄艮彬,齐育英,姚龙腾,等. 颅内感染成人患者血清和 脑脊液神经元特异性烯醇化酶、S100β蛋白含量测定及 意义[J]. 神经损伤与功能重建,2014,(2):156-157.
[11] 李晓莉,陈可夫. 颅脑伤患者血清IL-6、IL-8和NSE变化 与预后关系[J]. 基础医学与临床,2011,31(3):322-323.
[12] 朱 成,王 淮. 神经元特异性烯醇化酶检测对颅脑损 伤诊断分型及判断预后的临床意义[J]. 蚌埠医学院学 报,2014,39(1):50-52.
[13] 魏 风,陈 俭,黄 勤,等. 弥漫性轴索损伤患者血清 和脑脊液中NSE变化及临床意义[J]. 放射免疫学杂志, 2012,25(4):385-388.
[14] 王 斌,张 勇,刘晓辉,等. 急性颅脑损伤患者血清 CK-BB和NSE水平的变化及临床意义[J]. 徐州医学院学 报,2012,32(8):524-525.
[15] 万志强,郭德鸿. 脑震荡分级与血清动态神经元特异性 烯醇化酶的相关性研究[J]. 现代诊断与治疗,2013,(8): 1712-1713.

相似文献/References:

[1]张善纲 综述.现代战争中颅脑损伤的特点及功能康复[J].中国临床神经外科杂志,2015,(11):701.[doi:10.13798/j.issn.1009-153X.2015.11.021]
[2]钟秀均 黄书岚.复方醒脑液治疗颅脑损伤后综合征的临床观察[J].中国临床神经外科杂志,2016,(05):278.[doi:10.13798/j.issn.1009-153X.2016.05.007]
 ZHONG Xiu-jun,HUANG Shu-lan..Clinical observation on treatment of compound decoction for cerebral prorection for post-traumatic brain syndrome[J].,2016,(08):278.[doi:10.13798/j.issn.1009-153X.2016.05.007]
[3]李国亮 邸 方 杨亚东.香芹酚通过抑制脑水肿与氧化应激反应保护大鼠 颅脑损伤[J].中国临床神经外科杂志,2016,(05):283.[doi:10.13798/j.issn.1009-153X.2016.05.009]
 LI Guo-liang,DI Fang,YANG Ya-dong..Carvacrol protects against traumatic brain injury in rats through suppressing the brain edma and oxidative stress[J].,2016,(08):283.[doi:10.13798/j.issn.1009-153X.2016.05.009]
[4]罗心凯 陈治标 陈谦学.免缝胶原海绵人工硬脑膜在颅脑损伤大骨瓣减压术中的应用[J].中国临床神经外科杂志,2016,(06):357.[doi:10.13798/j.issn.1009-153X.2016.06.012]
 LUO Xin-kai,CHEN Zhi-biao,CHEN Qian-xue..Application of collagen sponge artificial dura without suturing to big bone flap decompression after traumatic brain injury[J].,2016,(08):357.[doi:10.13798/j.issn.1009-153X.2016.06.012]
[5]贺瑛福 肖宗宇 马进海 许常林 裴 杰 袁 岗 张广华  巨 虎.高海拔地区重型颅脑损伤血清FSH、LH、PRL的变化[J].中国临床神经外科杂志,2016,(06):359.[doi:10.13798/j.issn.1009-153X.2016.06.013]
 HE Ying-fu,XIAO Zong-yu,MA Jin-hai,et al.Changes in serum FSH, LH and PRL levels in the patients with severe traumatic brain injury in plateau[J].,2016,(08):359.[doi:10.13798/j.issn.1009-153X.2016.06.013]
[6]满明昊 李立宏 杨彦龙 李 敏 郭少春.颅脑损伤术后细胞免疫指标变化及脾多肽对其影响[J].中国临床神经外科杂志,2016,(06):362.[doi:10.13798/j.issn.1009-153X.2016.06.014]
 MAN Ming-hao,LI Li-hong,YANG Yan-yong,et al.Changes in peripheral cells immunity after operation and effect of spleen polypeptide on them in patients with traumatic brain injury[J].,2016,(08):362.[doi:10.13798/j.issn.1009-153X.2016.06.014]
[7]程 勇 秦加新 戢翰升 李 刚 聂劲林 李 强.颅脑损伤术中急性脑膨出的相关因素分析[J].中国临床神经外科杂志,2016,(06):374.[doi:10.13798/j.issn.1009-153X.2016.06.019]
[8]张一帆 综述 张国来 审校.弥漫性轴索损伤影像学诊断的研究进展[J].中国临床神经外科杂志,2016,(07):442.[doi:10.13798/j.issn.1009-153X.2016.07.020]
[9]陈吉钢 张丹枫 魏嘉良 邹 伟 侯立军.创伤性眶上裂综合征的治疗陈吉钢[J].中国临床神经外科杂志,2016,(04):200.[doi:10.13798/j.issn.1009-153X.2016.04.003]
 CHEN Ji-gang,ZHANG Dan-feng,WEI Jiang-liang,et al.Management of traumatic superior orbital fissure syndrome (report of 22 cases)[J].,2016,(08):200.[doi:10.13798/j.issn.1009-153X.2016.04.003]
[10]肖连福 黄瑞宏 陈昌勇.外伤性颅内静脉窦血栓形成1例[J].中国临床神经外科杂志,2016,(04):256.[doi:10.13798/j.issn.1009-153X.2016.04.024]

备注/Memo

备注/Memo:
通讯作者:陈治标,E-mail:chzbiao@126.com
更新日期/Last Update: 2016-08-25