[1]刘 琦 熊 丽 田少斌 陈劲松.原发性胶质母细胞瘤预后危险因素分析[J].中国临床神经外科杂志,2016,(06):341-343.[doi:10.13798/j.issn.1009-153X.2016.06.007]
 LIU Qi,XIONG Li,TIAN Shao-bin,et al.Analysis of risk factors related to prognoses in patients with primary glioblastomas[J].,2016,(06):341-343.[doi:10.13798/j.issn.1009-153X.2016.06.007]
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原发性胶质母细胞瘤预后危险因素分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年06期
页码:
341-343
栏目:
论著
出版日期:
2016-06-25

文章信息/Info

Title:
Analysis of risk factors related to prognoses in patients with primary glioblastomas
文章编号:
1009-153X(2016)06-0341-03
作者:
刘 琦 熊 丽 田少斌 陈劲松
431700 湖北,天门市第一人民医院神经外科(刘 琦、熊丽、田少斌、陈劲松)
Author(s):
LIU Qi XIONG Li TIAN Shao-bin CHEN Jin-song.
Department of Neurosurgery, The First People's Hospital of Tianmen City, Tianmen 431700, China
关键词:
原发性胶质母细胞瘤危险因素生存期
Keywords:
Primary glioblastoma Risk factor Prognosis Prognostic evaluation scale
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2016.06.007
文献标志码:
A
摘要:
目的 探讨原发性胶质母细胞瘤预后的危险因素。方法 收集1994~2014年收治的69例原发性胶质母细胞瘤的临床资料及肿瘤标本,以死亡作为随访终点,采用Cox比例风险模型筛选生存期危险因素。结果 本组随访时间为3.0~25.5个月,中位随访时间为11.0个月。单因素分析结果 显示,年龄≥50岁、肿瘤未全切、染色体1p/19q未缺失、异柠檬酸脱氢酶1(IDH1)未突变为生存期危险因素(P <0.05);Cox多因素分析结果 显示,年龄≥50岁及染色体1p/19q未缺失为独立危险因素(P <0.05)。将危险因素进行量化并分为高、中、低危组,中位无进展生存期分别为3.5、6.5、9.0个月,中位总体生存期为6.5、11.0、15.0个月;3组中位无进展生存期和中位总体生存期均有显著差异(P <0.05)。结论 年龄≥50岁、肿瘤未全切、1p/19q未缺失和IDH1未突变,是影响原发性GBM生存期的危险因素;将GBM生存期危险因素量化后进行分组,可为GBM个体化治疗提供一定帮助。
Abstract:
Objective To propose a prognostic evaluation scale for the patients with primary glioblastomas based on the risk factors related to the prognosis in order to provide theoretical reference for the individual treatment of patients with primary glioblatomas. Methods All the tumor samples and clinical data of 69 patients with primary glioblastomas treated in the First People’s Hospital of Tianmen City from 1994 to 2014 were collected in this study. Cox regression analysis was used to identify the risk factors related to prognoses in the patients with primary glioblactomas. Based on these risk factors, a prognostic evaluation scale was proposed. Results The univariate analysis showed that age ≥50 years, residual tumor after the surgery, 1p/19q maintenance and wild-type IDH1 which was not mutated were risk factors related to the prognoses in the patients with primary glioblactomas (P <0.05). The prognostic evaluation scale was proposed for the patients with primary glioblastomas on the basis of the above-mentioned risk factors related to the prognosis. Multivariate analysis revealed that age≥50 years and 1p/19q maintenance were independent risk factors related to the prognoses in the patients with primary glioblactomas (P <0.05). The prognostic evaluation scale could divided the patients with primary glioblastomas into 3 levels with remarkably different survival time (P <0.01). Conclusions The more the risk factors is, the higher the prognostic evaluation scale score is and poorer the prognosis is. This prognostic evaluation scale may provide the reference for the individual treatment of Chinese patients with primary glioblastomas.

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备注/Memo

备注/Memo:

通讯作者:陈劲松,E-mail:bohao_088@163.com
更新日期/Last Update: 2016-06-20