[1]刘璘琳 于耀宇 余天垒 裴美娟 唐 铸.改良ABCD2评分与头颈部CTA对TIA后脑梗死的预测价值[J].中国临床神经外科杂志,2016,(07):407-409.[doi:10.13798/j.issn.1009-153X.2016.07.006]
 LIU Lin-lin,YU Yao-yu,YU Tian-lei,et al.Values of modified ABCD2 score and cephalocervical CTA to predicting short-term risk of stroke after transient ischemic attack[J].,2016,(07):407-409.[doi:10.13798/j.issn.1009-153X.2016.07.006]
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改良ABCD2评分与头颈部CTA对TIA后脑梗死的预测价值()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年07期
页码:
407-409
栏目:
论著
出版日期:
2016-07-15

文章信息/Info

Title:
Values of modified ABCD2 score and cephalocervical CTA to predicting short-term risk of stroke after transient ischemic attack
文章编号:
1009-153X(2016)07-0407-03
作者:
刘璘琳 于耀宇 余天垒 裴美娟 唐 铸
300162 天津,武警后勤学院附属医院神经外科
通讯作者:于耀宇,E-mail:yuyaoyu666@aliyun.com
Author(s):
LIU Lin-lin YU Yao-yu YU Tian-lei PEI Mei-juan TANG Zhu.
Department of Neurosurgery, Affiliated Hospital, Logistics College, Chinese Armed Police Forces, Tianjin 300171, China
关键词:
短暂性脑缺血发作改良ABCD2 评分人血浆脂蛋白相关磷脂酶A2CT血管造影预测
Keywords:
Transient ischemic attack Ischemic stroke Modified ABCD2 score CTA Prediction
分类号:
R 743
DOI:
10.13798/j.issn.1009-153X.2016.07.006
文献标志码:
A
摘要:
目的 探讨应用改良ABCD2 评分及头颈部CT血管造影(CTA)对短暂性脑缺血发作(TIA)后7 d内脑梗死发生率的预测价值,并分析改良ABCD2评分及CTA的相关性。方法 回顾性分析698例TIA的临床资料及CTA资料。采用ABCD2评分法进行评分的同时,附加人血浆脂蛋白相关磷脂酶A2(Lp-PLA2)检测结果进行评分,分为低危组、中危组、高危组;根据头颈CTA血管狭窄程度分为正常或轻度狭窄、中度狭窄及重度狭窄。结果 698例TIA中,7 d内166例发生脑梗死;低危组、中危组及高危组脑梗死发生率呈现递增趋势(P<0.05)。责任血管重度狭窄组7 d内脑梗死发生率明显高于中度狭窄组(P<0.05),而中度狭窄组明显高于正常或轻度狭窄组(>P<0.05)。低危组、中危组及高危组责任血管重度狭窄率、多支血管病变比例均呈现递增趋势(>P<0.05),而3组病变血管位于前循环比例无统计学差异(>P>0.05)。结论 应用改良后ABCD2评分及CTA检查对TIA的脑梗死风险预测均有重要意义。
Abstract:
Objective To investigate the values of the modified ABCD2 score and cephalocervical CTA to predicting short-term risk of stroke after transient ischemic attack (TIA). Methods The modified ABCD2 score and cephalocervical CTA were performed in 698 patients after TIA, in whom the plasma levels of lipoprotein associated phospholipase A2 (Lp-PLA2) were determined. All the patients were divided into low stroke risk, moderate stroke risk and high stroke risk groups according to the modified ABCD 2 score combined with the plasma levels of Lp-PLA2 and they were divided into normal vessel, mild vascular stenosis, moderate vascular stenosis and severe vascular stenosis groups according to the cerebrovascular stenosis degree shown by cephalocervical CTA. The cerebral infarct (ischemia stroke) was assessed by the imaging examination and clinical symptoms. Results Of 698 patients with TIA, 237 were in the low stroke risk group, 305 in moderate stroke risk group and 156 in high stroke risk group. Of 698 patients with TIA, 502 were in normal vessels group, 33 in mild vascular stenosis group, 77 in moderate vascular stenosis group and 86 in severe vascular stenosis group. The rate of stroke (34.0%) was significantly higher in the high risk group than those (16.0% and 24.6% respectively) in the low risk and moderate risk groups (P<0.05). the="" rate="" of="" severe="" vascular="" stenosis="" (55.1%)="" was="" significantly="" higher="" in="" high="" risk="" group="" than="" those="" (13.9%="" and="" 25.2%="" respectively)="" low="" moderate="" groups="" (P<0.05). the="" rate="" of="" multiple="" vessel="" stenosis="" (66.0%)="" was="" significantly="" higher="" in="" high="" risk="" group="" than="" those="" (34.2%="" and="" 58.0%)="" low="" moderate="" groups="" (P

参考文献/References:

[1] Easton JD, Saver JL, Albers GW, et al. Definition and eva- luation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Asso- ciation/American Stroke Association Stroke Council; Coun- cil on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease--The American Academy of Neurology affirms the value of this statement as an edu- cational tool for neurologists. [J]. Stroke, 2009, 40(6): 2276- 2293.
[2] Coull AJ, Lovett JK, Rothwell PM. Population based study of early risk of stroke after transient ischaemic attack or minor stroke: implications for public education and organisation of services [J]. BMJ, 2004, 328(7435): 326.
[3] Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Vali- dation and refinement of scores to predict very early stroke risk after transient ischaemic attack [J]. Lancet, 2007, 369(9558): 283-292.
[4] Ay H, Arsava EM, Johnston SC, et al. Clinical-and imaging- based prediction of stroke risk after transient ischemic attack the CIP model [J]. Stroke, 2009, 40(1): 181-186.
[5] Engelter ST, Amort M, Jax F, et al. Optimizing the risk esti- mation after a transient ischaemic attack-The ABCDE score [J]. Eur J Neurol, 2012, 19(1): 55-61.
[6] Delgado P, Chacón P, Penalba A, et al. Lipoprotein-asso- ciated phospholipase A(2) activity is associated with large- artery atherosclerotic atiology and aecurrent atroke in TIA patients [J]. Cerebrovasc Dis, 2012, 33(2): 150-158.
[7] Clark TG, Murphy MFG, Rothwell PM. Long term risks of stroke, myocardial infarction, and vascular death in “low risk” patients with a non-recent transient ischaemic attack [J]. J Neurol Neurosurg Psychiatry, 2003, 74(5): 577-580.
[8] Sheehan OC, Merwick A, Kelly LA, et al. Diagnostic useful- ness of the ABCD2 score to distinguish transient ischemic attack and minor ischemic stroke from noncerebrovascular events: The North Dublin TIA Study [J]. Stroke, 2009, 40 (11): 3449-3454.
[9] Fothergill A, Christianson TJH, Brown RD, et al. Validation and refinement of the ABCD2 score a population-based analysis [J]. Stroke, 2009, 40(8): 2669-2673.
[10] Lavi S, McConnell JP, Rihal CS, et al. Local production of lipoprotein-associated phospholipase A2 and lysophospha- tidylcholine in the coronary circulation association with early coronary atherosclerosis and endothelial dysfunction in humans [J]. Circulation, 2007, 115(21): 2715-2721.
[11] Liu X, Zhu R X, Tian YL, et al. Association of PLA2G7 gene polymorphisms with ischemic stroke in northern Chinese Han population [J]. Clin Biochem, 2014, 47(6): 404-408.
[12] Cucchiara B L, Messe S R, Sansing L, et al. Lipoprotein- associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA [J]. Stroke, 2009, 40 (7): 2332-2336.
[13] Sheehan OC, Kyne L, Kelly LA, et al. Population-based study of ABCD2 score, carotid stenosis, and atrial fibrilla- tion for early stroke prediction after transient ischemic attack: The North Dublin TIA Study [J]. Stroke, 2010, 41 (5): 844-850.
[14] 吕璐璐,徐鹏,胡春峰,等. 头颈部CT血管造影和ABCD2 评分对短暂性脑缺血血管特征及介入疗效评价[J]. 介入 放射学杂志,2014,23(5):381-384.

更新日期/Last Update: 1900-01-01