[1]路 遥,祝 斐,金卫星,等.颅内静脉窦血栓形成的诊治分析[J].中国临床神经外科杂志,2016,(11):679-681.[doi:10.13798/j.issn.1009-153X.2016.11.009]
 LU Yao,ZHU Fei,JIN Wei-xing,et al.Clinical analysis of strategies of the diagnosis and treatment of cerebral venous sinus thrombosis[J].,2016,(11):679-681.[doi:10.13798/j.issn.1009-153X.2016.11.009]
点击复制

颅内静脉窦血栓形成的诊治分析()
分享到:

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年11期
页码:
679-681
栏目:
论著
出版日期:
2016-11-25

文章信息/Info

Title:
Clinical analysis of strategies of the diagnosis and treatment of cerebral venous sinus thrombosis
文章编号:
1009-153X(2016)11-0679-03
作者:
路 遥祝 斐金卫星陈 进汪勇军刘 鹏
332000 江西九江,中国人民解放军第171医院神经外科(路 遥、祝 斐、金卫星、陈 进、汪勇军);430070武汉,中国人民解放军武汉总医院神经外科(刘 鹏)
Author(s):
LU Yao1 ZHU Fei1 JIN Wei-xing1 CHEN Jin1 WANG Yong-jun1 LIU Peng1.
1. Department of Neurosurgery, The 171st Hospital, PLA, Jiujiang 332000, China;
2. Department of Neurosurgery, Wuhan General Hospital, PLA, Wuhan 430070, China
关键词:
颅内静脉窦血栓形成药物溶栓血管内溶栓疗效
Keywords:
Cerebral venous sinus thrombosis Anticoagulants Thrombolytic therapy
分类号:
R 743.9;R 815.2
DOI:
10.13798/j.issn.1009-153X.2016.11.009
文献标志码:
A
摘要:
目的 探讨颅内静脉窦血栓形成(CVST)诊断及治疗方法。方法 回顾性分析18例CVST的临床资料,根据临床表现、闭塞程度及侧支循环情况,10例接受单纯全身抗凝药物治疗,6例行单纯静脉溶栓,2例行全身抗凝+血管内溶栓治疗。结果 出院后随访6~23个月,平均12个月。单纯全身抗凝药物治疗的10例中,改良Rankin量表(mRS)评分0分6例,1分2例,3分2例。单纯静脉溶栓的6例中,mRS评分0分4例,1分1例,2分1例。全身抗凝+血管内溶栓治疗的2例中,mRS评分0分1例,3分1例。结论 CVST应根据临床表现、闭塞程度及侧支循环开放程度进行评估,从而选择个性化治疗方案。
Abstract:
Objective To discuss the clinical characteristics and the selection of diagnosis and treatment of cerebral venous sinus thrombosis (CVST). Methods The clinical data of 18 patients with CVST were analyzed retrospectively. Of 18 patients, 10 received systemic anticoagulant therapy, 6 intravenous thrombolytic therapy, and 2 systemic anticoagulant therapy and endovascular thrombolysis. Results Of 10 patients receiving systemic anticoagulant therapy, 6 were cured and 4 improved. Of 6 patients receiving intravenous thrombolytic therapy, 4 were cured and 2 improved. Of 2 patients receiving systemic anticoagulant therapy and endovascular thrombolysis, 1 was cured and 1 improved in the symptoms. The cerebral vein sinuses occluded by thrombosis were recanalized completely or in great part in all the patients after the treatment. There was no thrombosis again during the following up from 6 to 23 months in all the patients. Conclusion The individualized treatment should be selected according to the clinical manifestations and extents of occlusion of cerebral vein sinus and collateral circulation in the patients with CVST.

参考文献/References:

[1] Stam J. Thrombosis of the cerebral veins and sinuses [J]. N Engl J Med, 2005. 352(17): 1791-1798.
[2] Saposnik G, Barinagarrementeria F, Brown RD Jr, et al. Diagnosis and management of cerebral venous thrombosis: a statement for healthcare professionals from the American Heart Association/American Stroke Association [J]. Stroke, 2011, 42(4): 1158-1192.
[3] Stam J. Sinus thrombosis should be treated with anticoagu- lation [J]. Arch Neurol, 2008, 65(7): 984-985.
[4] Coutinho J, de Bruijn SF, Deveber G, et al. Anticoagulation for cerebral venous sinus thrombosis [J]. Cochrane Database Syst Rev, 2011, (8): CD002005.
[5] Einhaupl K, Stam J, Bousser MG, et al. EFNS guideline on the treatment of cerebral venous and sinus thrombosis in adult patients [J]. Eur J Neurol, 2010, 17(10): 1229-1235.
[6] Einhaupl K, Bousser MG, de Bruijn SF, et al. EFNS guide- line on the treatment of cerebral venous and sinus thrombo- sis [J]. Eur J Neurol, 2006, 13(6): 553-559.
[7] Ferro JM, Canhao P, Stam J, et al. Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis(ISCVT) [J]. Stroke, 2004, 35(3): 664-670.
[8] Wasay M, Bakshi R, Kojan S, et al. Nonrandomized compa- rison of local urokinase thrombolysis versus systemic hepa- rin anticoagulation for superior sagittal sinus thrombosis [J]. Stroke, 2001, 32(10): 2310-2317.
[9] Misra UK, Kalita J, Chandra S, et al. Low molecular weight heparin versus unfractionated heparin in cerebral venous sinus thrombosis: a randomized controlled trial [J]. Eur J Neurol, 2012, 19(7): 1030-1036.
[10] Scott JA, Pascuzzi RM, Hall PV, et al. Treatment of dural sinus thrombosis with local urokinase infusion: case report [J]. J Neurosurg, 1988, 68(2): 284-287.
[11] Barnwell SL, Higashida RT, Halbach VV, et al. Direct endovascular thrombolytic therapy for dural sinus thrombo- sis [J]. Neurosurgery, 1991, 28(1): 135-142.
[12] Guo XB, Guan S, Fan Y, et al. Local thrombolysis for severe cerebral venous sinus thrombosis [J]. Am J Neuroradiol, 2012, 33(6): 1187-1190.
[13] Dentali F, Squizzato A, Gianni M, et al. Safety of thromboly- sis in cerebral venous thrombosis: a systematic review of the literature [J]. Thromb Haemost, 2010, 104: 1055-1062.
[14] Stam J, Majoie CB, van Delden OM, et al. Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis: a prospective study [J]. Stroke, 2008, 39(5): 1487-1490.
[15] Renowden S. Cerebral venous thrombosis: local thrombolysis [J]. J R Soc Med, 2000, 93(5): 241-243.
[16] Liebetrau M, Mayer TE, Bruning R, et al. Intra-arterial thrombolysis of complete deep cerebral venous thrombosis [J]. Neurology, 2004, 63(12): 2444-2445.

相似文献/References:

[1]苏家豪 林少华 廖 巍等.颅内静脉窦、静脉血栓形成伴脑出血致脑疝的治疗[J].中国临床神经外科杂志,2021,26(02):119.[doi:10.13798/j.issn.1009-153X.2021.02.018]
[2]张心红,王凤英.妊娠相关颅内静脉窦血栓形成50例报道[J].中国临床神经外科杂志,2022,27(06):493.[doi:10.13798/j.issn.1009-153X.2022.06.021]
[3]林宝利,韦巧珍,陈民.重症颅内静脉窦血栓形成病人的治疗体会[J].中国临床神经外科杂志,2022,27(12):1008.[doi:10.13798/j.issn.1009-153X.2022.12.017]

备注/Memo

备注/Memo:
通讯作者:刘 鹏,E-mail:5564793@qq.com
更新日期/Last Update: 2016-11-25