[1]闵　朋,杨　锐.脑震荡综合征的静息态功能MRI分析[J].中国临床神经外科杂志,2016,(12):740-742.[doi:10.13798/j.issn.1009-153X.2016.12.002]
　MIN Peng,YANG Rui.Analysis of postconcussion syndrome by resting state functional MRI[J].,2016,(12):740-742.[doi:10.13798/j.issn.1009-153X.2016.12.002]
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脑震荡综合征的静息态功能MRI分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年12期
页码:
740-742
栏目:
论著
出版日期:
2016-12-25

文章信息/Info

Title:
Analysis of postconcussion syndrome by resting state functional MRI
文章编号:
1009-153X（2016）12-0740-04
作者:
闵　朋; 杨　锐
442000 湖北十堰，湖北医药学院附属东风医院磁共振室（闵　朋,杨　锐）
Author(s):
MIN Peng;  YANG Rui
MRI Room, Dongfeng Hospital Affiliated to Hubei College of Medicine, Shiyan 442000, China
关键词:
脑震荡综合征; 静息态功能MRI; 脑白质; 相关性
Keywords:
Postconcussion syndrome;  Resting state functional MRI;  Cerebral white matter;  Relationship
分类号:
R 651.1+5; R 445.2
DOI:
10.13798/j.issn.1009-153X.2016.12.002
文献标志码:
A
摘要:
目的 探讨静息态功能MRI（rs-fMRI）在脑震荡综合征诊断中的价值。方法 选择2013年2月到2016年5月在我院诊治的脑震荡综合征36例作为观察组，选择同期在我院进行体检的健康人36例作为对照组。两组都进行脑震荡综合征问卷调查表（RPSQ）评分，同时进行rs-fMRI检查。结果 观察组RPSQ评分[（11.44±2.19）分]明显低于对照组[（17.22±1.93）分；P<0.05]。与对照组相比，观察组双侧扣带回前部皮层在Slow-5亚频段分数低频振幅（fALFF）显著增高（P<0.05），而显著减低的脑区为双侧枕中回和楔前叶（P<0.05）；观察组左侧颞下回在Slow-4亚频段fALFF显著增高（P<0.05）。观察组扣带回前部,左侧颞下回fALFF与RPSQ评分水平呈显著负相关（r分别为-0.456,-0.547；P<0.05）；而双侧枕中回和楔前叶fALFF与RPSQ评分水平呈明显正相关（r分别为0.598,0.585；P<0.05）。结论 rs-fMRI检查能反映脑震荡综合征脑白质的轻微异常情况，可提供病理层面的检测客观证据。
Abstract:
Objective To investigate the value of resting state functional MRI (rs-fMRI) to the diagnosis of postconcussion syndrome. Methods Thirty-six patients with postconcussion syndrome treated in our hospital from February, 2013 to May, 2016 served as the observation group, and 36 healthy subjects receiving health examination in our hospital at the same period served as the control group. The postconcussion syndrome questionnaire (PCSQ) investigation was performed in all the subjects. The relationship of PCSQ scores with rs-fMRI was analyzed. Results The PCSQ scores [(11.44±2.19) points] were significantly lower in the observed group than those [(17.22±1.93) points] in the control group (P<0.05). The Slow-5 subfrequency fractional amplitude of low frequency fluctuation (fALFF) of bilateral anteriomedial cingulate cortexes was significantly higher (P<0.05), and the fALFF of the bilateral medial occipital gyri and precuneuses were significantly lower in the observation group than those in the control group (P<0.05). The Slow-4 subfrequency fALFF of the left inferior temporal gyrus was significantly higher in the observation group than that in the control group (P<0.05). In the observation group, Spearman analysis showed that the fALFF of the anterior cingulate gyrus and left inferior temporal gyrus were negatively related to the PCSQ scores (r=-0.456, r=-0.547, respectively; P<0.05), and the fALFF of bilateral anteriomedial occipital gyri and precuneuses were positively related to the PCSQ scores in the observed group (r=0.598, r=0.585, respectively; P<0.05). Conclusion The rs-fMRI can reflect the mild abnormality of the cerebral white matter in the patients with postconcussion syndrome and therefore it can provide the objective evidence of the pathological level, and it is of value to the diagnosis in the patients with postconcussion syndrome.

参考文献/References:

[1] 李顺利，钱若兵，傅先明，等. 脑震荡综合征患者脑网络小 世界属性变化的静息态功能MRI研究[J]. 中华神经外科 杂志，2015，31（11）：1151-1155.
[2] 马海文，崔红英，黄松涛. 磁共振扩散张量成像对轻型颅 脑损伤的临床诊断价值[J]. 中国临床神经科学，2016，24 （1）：75-78.
[3] Tal S, Hadanny A, Berkovitz N, et al. Hyperbaric oxygen may induce angiogenesis in patients suffering from pro- longed postconcussion syndrome due to traumatic brain injury [J]. Restor Neurol Neurosci, 2015, 33(6): 943-951.
[4] Morgan CD, Zuckerman SL, King LE, et al. Post-concussio syndrome (PCS) in a youth population: defining the diagnos- tic value and cost-utility of brain imaging [J]. Childs Nerv Syst, 2015, 31(12): 2305-2309.
[5] 彭　楠，傅先明，钱若兵，等. 脑震荡综合征患者脑网络的 度属性研究[J]. 中华神经医学杂志，2015，14（6）：619- 622.
[6] 李　晋，左　超，刘云阳，等. 磁共振扩散张量成像对轻型 颅脑损伤患者评价的临床应用[J]. 磁共振成像，2015， 11（4）：271-276.
[7] da Costa L, van Niftrik CB, Crane D, et al. Temporal profile of cerebrovascular reactivity impairment, gray matter volumes, and persistent symptoms after mild traumatic head injury [J]. Front Neurol, 2016, 11(7): 70-77.
[8] 王聚宝，沈海林，杜红娣，等. 弥散张量成像基于体素水平 的定量分析在脑震荡综合征中的初步应用[J]. 中国血液 流变学杂志，2014，13（1）：166-169.
[9] Delouche A, Attyé A, Heck O, et al. Diffusion MRI: pitfalls, literature review and future directions of research in mild traumatic brain injury [J]. Eur J Radiol, 2016, 85(1): 25- 30.
[10] Mutch WA, Ellis MJ, Ryner LN, et al. Longitudinal brain magnetic resonance imaging CO2 stress testing in individual adolescent sports-related concussion patients: a pilot study [J]. Front Neurol, 2016, 8(7): 107-111.
[11] 李　洁，丁建平. 轻度创伤性脑损伤的功能磁共振研究 进展[J]. 实用放射学杂志，2014，8（12）：2094-2096.
[12] 郜玉婷，姚晓娟，毓　青，等. 颞叶癫痫伴抑郁状态患者 静息态功能磁共振脑网络研究[J]. 中华医学杂志，2016， 96（21）：1696-1698.
[13] 张　楠，路俊锋，吴劲松. 功能磁共振成像用于脑语言区 定位的研究进展[J]. 中华外科杂志，2016，54（2）：157- 160.
[14] 魏　歆，李传明，周振华，等. 原发性失眠伴认知功能障 碍患者静息态功能MRI的局部一致性研究[J]. 中华放射 学杂志，2016，50（6）：401-405.

备注/Memo

备注/Memo:
基金项目：湖北省十堰市科学技术研究与开发项目（14Y56） 作者单位：442000 湖北十堰，湖北医药学院附属东风医院磁共振室（闵　朋,杨　锐） 通讯作者：杨　锐，E-mail：yangrui5922@163.com
更新日期/Last Update: 1900-01-01