[1]张 林 何裕超 营国龙 谢宝树 姚文益 高卫真 贾 锋 殷玉华.脑膜瘤Ki-67表达与瘤周水肿的相关性[J].中国临床神经外科杂志,2017,(03):168-170.[doi:10.13798/j.issn.1009-153X.2017.03.014]
 ZHANG Lin,HE Yu-chao,YING Guo-long,et al.Correlativity between Ki-67 expression and peritumorous brain edema in intracranial meningiomas[J].,2017,(03):168-170.[doi:10.13798/j.issn.1009-153X.2017.03.014]
点击复制

脑膜瘤Ki-67表达与瘤周水肿的相关性()
分享到:

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年03期
页码:
168-170
栏目:
论著
出版日期:
2017-03-20

文章信息/Info

Title:
Correlativity between Ki-67 expression and peritumorous brain edema in intracranial meningiomas
文章编号:
1009-153X(2017)03-0168-03
作者:
张 林 何裕超 营国龙 谢宝树 姚文益 高卫真 贾 锋 殷玉华
200127 上海,上海交通大学医学院附属仁济医院神经外科(张 林、谢宝树、姚文益、高卫真、贾 锋、殷玉华);223800 江苏,宿迁市第一人民医院神经外科(何裕超);237400 安徽,六安市霍邱县第一人民医院神经外科(营国龙)
Author(s):
ZHANG Lin1 HE Yu-chao2 YING Guo-long3 XIE Bao-shu1 YAO Wen-yi1 GAO Wei-zhen1 JIA Feng1 YIN Yu-hua1.
1. Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China;
2. Department of Neurosurgery, The First People's Hospital of Suqian City, Suqian 223800, China;
3. Department of Neurosurge
关键词:
脑膜瘤Ki-67瘤周水肿相关性
Keywords:
Intracranial meningiomas Ki-67 Expression Peritumorous brain edema Correlativity
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2017.03.014
文献标志码:
A
摘要:
目的 探讨脑膜瘤MRI显示瘤周水肿程度与肿瘤组织Ki-67表达水平的相关性。方法 收集2013年1月至2016年1月经手术切除及病理组织学证实的脑膜瘤标本159例,采用免疫组织化学染色方法检测Ki-67的表达;术前头颅MRI评估瘤周水肿程度。结果 159例中,无瘤周水肿21例,Ⅰ度水肿60例,Ⅱ度水肿29例,Ⅲ度水肿49例;瘤周水肿发生率为86.8%(138/159)。脑膜瘤组织Ki-67阴性表达为108例,弱阳性为25例,阳性为11例,强阳性为15例。脑膜瘤瘤周水肿程度与肿瘤组织Ki-67表达水平呈正相关(rs=0.486;P<0.001)。结论 术前影像学检查评估脑膜瘤瘤周水肿程度,可作为预测Ki-67的表达水平及肿瘤恶性程度的因素之一,可为临床制定合理的治疗方案及判断预后提供重要依据。
Abstract:
Objective To analyze the correlativity between the level of Ki-67 expression and peritumorous brain edema (PTBE) in the patients with intracranial meningiomas. Methods The expression of Ki-67 was detected by immunohistochemical staining in 159 specimens of the intracranial meningiomas confirmed by histopathological examination from January, 2013 to January, 2016. The degree of PTBE was evaluated by preoperative MRI in all the patients with intracranial meningiomas serving as the above-mentioned specimens. The correlativity between the level of Ki-67 expression in the timorous tissues and PTBE was analyzed by statistical method. Results There was significant difference in the level of Ki-67 expression among the meningiomas tissues with different degrees of PTBE (P<0.05). The levels of Ki-67 expression were positively correlated with the degree of PTBE (rs=0.486; P<0.01). Conclusion It is suggested that the degree of PTBE evaluated by preoperative MRI may be used to predict the expression of Ki-67 and the grade of malignancy of meningiomas, thus providing a significant basis for proper therapy and prognositic prediction.

参考文献/References:

[1] Whittle IR, Smith C, Navoo P, et al. Meningiomas [J]. Lan- cet, 2004, 363(9420): 1535-1543.
[2] Louis DN, Perry A, Reifenberger G, et al. The 2016 world health organization classification of tumors of the central nervous system: a summary [J]. Acta Neuropathol, 2016, 131(6): 803-820.
[3] 彭 龙,侯庆石. 脑膜瘤瘤周水肿机制研究进展[J]. 中国 临床神经外科杂志,2012,17(3):189-192.
[4] 王米君,舒 凯. 脑膜瘤瘤周水肿的研究现状[J]. 中国临 床神经外科杂志,2015,20(5):315-317.
[5] Osawa T, Tosaka M, Nagaishi M, et al. Factors affecting peritumoral brain edema in meningioma: special histological subtypes with prominently extensive edema [J]. J Neuroon- col, 2013, 111(1): 49-57.
[6] 董 驰,周俊林,段国兰,等. 颅内血管外皮细胞瘤瘤周水 肿与肿瘤侵袭性的关系[J]. 临床神经外科杂志, 2010, 7(1):17-20.
[7] Nakano T, Asano K, Miura H, et al. Meningiomas with brain edema: radiological characteristics on MRI and review of the literature [J]. Clin Imaging, 2002, 26(4): 243-249.
[8] Simis A, Pires De Aguiar PH, Leite CC, et al. Peritumoral brain edema in benign meningiomas: correlation with clini- cal, radiologic, and surgical factors and possible role on recurrence [J]. Surg Neurol, 2008, 70(5): 471-477.
[9] Schoenegger K, Oberndorfer S, Wuschitz B, et al. Peritumo- ral edema on MRI at initial diagnosis: an independent pro- gnostic factor for glioblastoma [J]? Eur J Neurol, 2009, 16 (7): 874-878.
[10] Wang W, Da R, Wang M, et al. Expression of brain-specific angiogenesis inhibitor 1 is inversely correlated with patho- logical grade, angiogenesis and peritumoral brain edema in human astrocytomas [J]. Oncol Lett, 2013, 5(5): 1513-1518.
[11] Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown [J]. J Cell Physiol, 2000, 182(3): 311-322.
[12] Abry E, Thomassen I, Salvesen O, et al. The significance of Ki-67/MIB-1 labeling index in human meningiomas: a literature study [J]. Pathol Res Pract, 2010, 206: 810-815.
[13] Kayaselcuk F, Zorludemir S, Bal N, et al. The expression of survivin and Ki-67 in meningiomas: correlation with grade and clinical outcome [J]. J Neurooncol, 2004, 67: 209-214.
[14] 洪文瑶,刘宇清,陈明武,等. Ki-67在侵袭性脑膜瘤的表 达与意义 [J]. 中国微侵袭神经外科杂志, 2014,19(8): 372-374.
[15] Perry A, Scheithauer BW, Stafford SL, et al. "Malignancy" in meningiomas: a clinicopathologic study of 116 patients, with grading implications [J]. Cancer, 1999, 85: 2046-2056.

相似文献/References:

[1]李春坡 郑 军 李海元 边 涛 韩安国.侧脑室三角区小型脑膜瘤的显微外科治疗[J].中国临床神经外科杂志,2015,(11):694.[doi:10.13798/j.issn.1009-153X.2015.11.018]
[2]王林风 郑华山 操 廉.中央沟区矢状窦旁脑膜瘤的显微手术治疗(附25例报告)[J].中国临床神经外科杂志,2016,(07):431.[doi:10.13798/j.issn.1009-153X.2016.07.014]
[3]邓学云 刘 毅 范润金 刘丽华 夏祥国.E-cadherin与脑膜瘤分级及瘤周水肿的关系[J].中国临床神经外科杂志,2016,(04):213.[doi:10.13798/j.issn.1009-153X.2016.04.007]
 DENG Xue-yun,LIU Yi,FAN Run-jin,et al.Relationship of E-cadherin with the pathological grade of meningioma and peritumoral brain edema in patients with meningioma[J].,2016,(03):213.[doi:10.13798/j.issn.1009-153X.2016.04.007]
[4]马 磊 张海红 郭 康 孙树凯 张 亮 贾 栋.神经导航辅助下手术治疗侧脑室脑膜瘤1例[J].中国临床神经外科杂志,2016,(04):255.[doi:10.13798/j.issn.1009-153X.2016.04.023]
[5]王 一 崔焕喜 林令超 孙思辉 李绍山 周庆九 刘 波 柳 琛.侧脑室三角区脑膜瘤的显微手术治疗[J].中国临床神经外科杂志,2016,(03):161.[doi:10.13798/j.issn.1009-153X.2016.03.010]
 WANG Yi,CUI Huan-xi,LIN Ling-chao,et al.Microsurgery for meningiomas in the trigones of lateral ventricles (report of 47 cases)[J].,2016,(03):161.[doi:10.13798/j.issn.1009-153X.2016.03.010]
[6]王 鹏 综述 王 勇 审校.岩斜区脑膜瘤的手术入路[J].中国临床神经外科杂志,2016,(02):120.[doi:10.13798/j.issn.1009-153X.2016.02.024]
[7]漆松涛 刘 忆.关于WHO2007年版脑膜瘤病理分类一些问题的商榷[J].中国临床神经外科杂志,2016,(02):125.[doi:10.13798/j.issn.1009-153X.2016.02.026]
[8]李登辉 程 荆 李志强.镰旁脑膜瘤术后并发格林巴利综合征1例[J].中国临床神经外科杂志,2016,(02):72.[doi:10.13798/j.issn.1009-153X.2016.02.003]
[9]肖宗宇 陈晓娟 裴 杰 贺瑛福 许常林 马进海.超声吸引器在脑膜瘤手术切除中的应用[J].中国临床神经外科杂志,2015,(10):626.[doi:10.13798/j.issn.1009-153X.2015.10.016]
[10]杨 俊 吴雪松 莫鸿忠 潘荣南 赖 杰.双源CT三维血管成像技术在脑膜瘤术前评估中的应用[J].中国临床神经外科杂志,2015,(06):347.[doi:10.13798/j.issn.1009-153X.2015.06.009]
 YANG Jun,WU Xue-song,MO Hong-zhong,et al.Application of three-dimensional dual-source CT angiography to preoperative assessment of meningiomas[J].,2015,(03):347.[doi:10.13798/j.issn.1009-153X.2015.06.009]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81471855)
通讯作者:殷玉华,E-mail:yinyuhuacn@163.com
更新日期/Last Update: 2017-03-25