[1]杨文进　郭义君　童武松　郑　平　汪瑞忠　焦荣红　何　斌　陈　磊.急性颅脑损伤后早期血清Tau蛋白的动态变化及临床意义[J].中国临床神经外科杂志,2017,(08):536-538.[doi:10.13798/j.issn.1009-153X.2017.08.004]
　YANG Wen-jin,GUO Yi-jun,TONG Wu-song,et al.Dynamic change in serum level of tau protein and its clinical meanings in patients with acute traumatic brain injury[J].,2017,(08):536-538.[doi:10.13798/j.issn.1009-153X.2017.08.004]
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急性颅脑损伤后早期血清Tau蛋白的动态变化及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年08期
页码:
536-538
栏目:
论著
出版日期:
2017-08-25

文章信息/Info

Title:
Dynamic change in serum level of tau protein and its clinical meanings in patients with acute traumatic brain injury
文章编号:
1009-153X（2017）08-0536-03
作者:
杨文进　郭义君　童武松　郑　平　汪瑞忠　焦荣红　何　斌　陈　磊
201299，上海市浦东新区人民医院神经外科（杨文进、郭义君、童武松、郑　平、何　斌、陈　磊），检验科（汪瑞忠、焦荣红）
Author(s):
YANG Wen-jin1;  GUO Yi-jun1;  TONG Wu-song1;  ZHENG Ping1;  WANG Rui-zhong2;  JIAO Rong-hong2;  HE Bin1;  CHEN Lei1.
Department of Neurosurgery, Pudong New Area People’s Hospital, Shanghai 201299, China; 2. Laboratory, Pudong New Area People’s Hospital, Shanghai 201299, China
关键词:
颅脑损伤; 血清; Tau蛋白; 预后
Keywords:
Traumatic brain injury;  Serum;  Tau protein;  Severity;  Prognosis;  Relationship
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2017.08.004
文献标志码:
A
摘要:
目的 探讨急性颅脑损伤（TBI）后血清Tau蛋白的变化及其与损伤程度和预后的相关性。方法 前瞻性收集急性TBI 229例，入院时GCS评分3~8分31例（重型组），9~12分23例（中型组），13~15分175例（轻型组）。另取来本院同期体检的正常成年人30例作为对照组。伤后1、3、5、7、14 d检测血清Tau含量。伤后6个月采用GOS评分评估预后，1~3 分为预后不良，4~5分为预后良好。结果 TBI后血清Tau蛋白含量先进行性升高，伤后5 d达峰值，伤后7 d开始下降，但仍明显高于对照组（P<0.05）。血清Tau蛋白含量随TBI损伤程度加重显著增高（P<0.05），伤后1、3、5 d，血清Tau蛋白含量与入院时GCS评分呈明显正相关（r分别为0.7348、0.5232、0.4402；P<0.05）。预后不良组伤后1、3、5、7 d血清Tau蛋白均显著高于预后良好组（P<0.05，伤后1、3、5、7 d，血清Tau蛋白含量与伤后6个月GOS评分呈明显负相关（r分别为0.4388、0.4868、0.3702、0.3517；P<0.05）。结论 TBI后早期血清Tau含量变化与损伤程度和预后相关，可作为判断TBI严重程度及预测TBI预后的生物学指标。
Abstract:
Objective To investigate the dynamic change in the serum level of tau protein early after acute traumatic brain injury (TBI) and its clinical meanings. Methods Of 229 patients with acute TBI, 175 had mild TBI, 23 medium and 31 severe according to GCS. The serum levels of tau protein were determined in 30 healthy subjects and all the patients 1, 3, 5, 7 and 14 days after TBI. The relationships of the serum levels of tau protein with the initial GCS and GOS 6 months after the injury were analyzed. Results The serum levels of tau protein were significantly higher in the patients with mild, medium and severe TBI 1, 3, 5, 7, and 14 days after TBI than that of the healthy subjects (P<0.05). The serum levels of tau protein 1, 3, 5, 7, and 14 days after TBI were significantly lower respectively in the patients with mild TBI than those in the patients with medium and severe TBI (P<0.05). The serum levels of tau protein were significantly lower in the patients with mild TBI respectively than those in the patients with severe TBI 1, 3 and 5 days after TBI (P<0.05). The serum levels of tau protein were significantly lower in the patients with good prognoses respectively than those in the patients with poor prognoses 1, 3, 5, 7 and 14 days after TBI (P<0.05). The serum levels of tau protein 1, 3 and 5 days after TBI were negatively related with the GCS and the serum levels of tau protein 1, 3, 5 and 7 days after TBI were negatively related with GOS (P<0.05). Conclusions It is suggested that the dynamic change in the serum levels of tau protein in patients with acute TBI may be used as a reliable biological index of TBI severity and prognosis because their dynamic change was negatively related to the TBI severity and the patients’ prognoses.

参考文献/References:

[1] Woertgen C, Rothoerl R, Metz C, et al. Comparison of clini- cal, radiologic, and serum marker as prognostic factors after severe head injury [J]. Trauma, 1999, 47(6): 1126-1130.
[2] Spillantini MG, Goedert M. Tau pathology and neurodege- neration [J]. Lancet Neurol, 2013, 12(6): 609-622.
[3] Zanier ER, Zoerle T, Fiorini M, et al. Heart-fatty acid- binding and tau proteins relate to brain injury severity and long-term outcome in subarachnoid haemorrhage patients [J]. Br J Anaesth, 2013, 111(3): 424-432.
[4] Kuznetsov IA, Kuznetsov AV. What tau distribution maxi- mizes fast axonal transport toward the axonal synapse [J]? Math Biosci, 2014, 253(1): 19-24.
[5] Arun P, Abu-Taleb R, Oguntayo S, et al. Distinct patterns of expression of traumatic brain injury biomarkers after blast exposure: role of compromised cell membrane integrity [J]. Neurosci Lett, 2013, 27(552): 87-91.
[6] Takahashi K, Hasegawa S, Maeba S, et al. Serum tau protein level serves as a predictive factor for neurological prognosis in neonatal asphyxia [J]. Brain Dev, 2014, 36(8): 670675.
[7] Rubenstein R, Chang B, Davies P, et al. A novel, ultra sen- sitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids [J]. Neurotrauma, 2015, 32(5): 342-352.
[8] Magnoni S, Esparza TJ, Conte V, et al. Tau elevations in the brain extracellular space correlate with reduced amyloid beta levels and predict adverse clinical outcomes after severe traumatic brain injury [J]. Brain, 2012, 135(4): 1268-1280.
[9] Liliang PC, Liang CL, Lu K, et al. Relationship between injury severity and serum tau protein levels in traumatic brain injured rats [J]. Resuscitation, 2010, 81: 1205-1208.
[10] Franz G, beer R, Kampfl A, et al. Amyloid beta 1-42 and tau in cerebrospinal fluid after severe traumatic brain injury [J]. Neurology, 2003, 60(9): 1457-1461.
[11] Ost M, Nylen K, Csajbok L, et al. Initial CSF total tau corre- lates with 1-year outcome in patients with traumatic brain injury [J]. Neurology, 2006, 67(9): 1600-1604.
[12] Johnson VE, Stewart W, Smith DH. Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans [J]. Brain Pathol, 2012, 22(2): 142- 149.
[13] Santacruz K, Lewis J, Spires T, et al. Tau suppression in a neurodegenerative mouse model improves memory function [J]. Science, 2005, 309(5733): 476-481.
[14] Dawson HN, Cantillana V, Jansen M, et al. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer’s dis- ease [J]. Neuroscience, 2010, 169(1): 516-531.
[15] Shultz SR, Wright DK, Zheng P, et al. Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury [J]. Brain, 2015, 138(12): 1297- 1313.

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备注/Memo

备注/Memo:
基金项目：上海市卫计委科研课题（201440067）；上海市浦东新区科技发展基金基金（PKJ2015-Y45）；上海市浦东新区卫生系统重点专科建设专项基金（PWZz2013-13） 作者单位：201299，上海市浦东新区人民医院神经外科（杨文进、郭义君、童武松、郑　平、何　斌、陈　磊），检验科（汪瑞忠、焦荣红） 通讯作者：童武松，E-mail：tongws0599@163.com
更新日期/Last Update: 1900-01-01