[1]王 佳 王焕明 封 华 梁 奕 杜柏林 徐海波.弥漫性胶质瘤VEGF、MMP-9及uPA表达水平分析[J].中国临床神经外科杂志,2017,(08):560-562.[doi:10.13798/j.issn.1009-153X.2017.08.013]
 WANG Jia,WANG Huan-ming,FENG Hua,et al.Relationship of pathological grade of diffuse glioma with the expressions of VEGF, MMP-9 and uPA in glioma tissues[J].,2017,(08):560-562.[doi:10.13798/j.issn.1009-153X.2017.08.013]
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弥漫性胶质瘤VEGF、MMP-9及uPA表达水平分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年08期
页码:
560-562
栏目:
论著
出版日期:
2017-08-25

文章信息/Info

Title:
Relationship of pathological grade of diffuse glioma with the expressions of VEGF, MMP-9 and uPA in glioma tissues
文章编号:
1009-153X(2017)07-0560-03
作者:
王 佳 王焕明 封 华 梁 奕 杜柏林 徐海波
430010 武汉,长江航运总医院影像科(王 佳、梁 奕、杜柏林),神经外科(王焕明),病理科(封 华);430071 武汉,武汉大学中南医院影像科(徐海波)
Author(s):
WANG Jia1 WANG Huan-ming2 FENG Hua3 LIANG Yi1 DU Bo-lin1 XU Hai-bo4.
1. Department of Radiology, General Hospital of the Yangtze River Shipping, Wuhan 430010, China; 2. Department of Neurosurgery, General Hospital of the Yangtze River Shipping, Wuhan 430010, China; 3. Department of Pathology, General Hospital of the Yangtze River Shipping, Wuhan 430010, China; 4. Department of Radiology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
关键词:
弥漫性胶质瘤病理级别血管内皮生长因子基质金属蛋白酶-9尿激酶型纤溶酶原激活剂相关性
Keywords:
Diffuse glioma Pathological level VEGF MMP-9 uPA Expression Relationship
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2017.08.013
文献标志码:
A
摘要:
目的 探讨弥漫性胶质瘤组织血管内皮生长因子(VEGF)、基质金属蛋白酶(MMP)-9和尿激酶型纤溶酶原激活剂(uPA)表达水平与胶质瘤级别的相关性。方法 收集2013~2016年手术切除的弥漫性胶质瘤标本45例,其中低级别胶质瘤20例(WHO Ⅱ级),高级别胶质瘤25例(WHO Ⅲ~Ⅳ级)。采用免疫组化染色方法检测VEGF、MMP-9及uPA的表达水平。结果 高级别胶质瘤VEGF、MMP-9表达水平明显高于低级别胶质瘤(P<0.05),不同级别胶质瘤uPA表达水平无明显差异(P>0.05)。结论 VEGF、MMP-9在弥漫性胶质瘤发生发展中可能具有重要促进作用。
Abstract:
Objective To evaluate the relationship of pathological grade of diffuse glioma with the expressions of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) and urokinase plasminogen activator (uPA) in the glioma tissues. Methods The expressions of MMP-9, VEGF and uPA were determined by immunohistochemical method in 20 samples of diffuse low-grade gliomas tissues (low grade group) and 25 samples of diffuse high-grade gliomas tissues (high grade group). The relationship of pathological grade of gliomas with the expressions of VEGF, MMP-9 and uPA was analyzed. Results The rates of positive expressions of VEGF and MMP-9 were significantly higher in the high grade group respectively than those in the low grade group (P<0.05), but there was insignificantly difference in the positive expression rate of uPA between both the groups (P>0.05). Conclusion It is suggested that the high expressions of VEGF, MMP-9 may play important roles in the pathogenesis and development of diffuse gliomas.

参考文献/References:

[1] Rabi ZA, Todorovic-Rakovic N, Vujasinovic T, et al. Mar- kers of progresssion and invasion in short term follow up of untreated breast cancer patients [J]. Cancer Biomark, 2015, 15(6): 745-754.
[2] Ma YS, Hsiao YP, Lin JH, et al. Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling [J]. Environ Toxico, 2015, 30(7): 852-863.
[3] Tanaka K, Lwamoto S, Gon G, et al. Expression of survivin and its relationship to loss of apopotosis in breast carcino- mas [J]. Clin Cance Res, 2000, 6(1):127-134.
[4] 杨学军, 江 涛. 解读《世界卫生组织中枢神经系统肿瘤 分类(2016年)》[J]. 中国神经精神疾病杂志,2016,42 (6):321-329.
[5] 韩 彤,张云亭,刘 力,等. 星形细胞肿瘤磁敏感加权 成像和灌注成像测量指标与肿瘤内微血管密度和血管 内皮细胞生长因子的相关性研究[J]. 中华放射学杂志, 2013,47(12):1086-1091.
[6] 刘宏雷,易 力,翟晓莉. 脑星形细胞瘤中eIF4E、VEGF 的表达及意义[J]. 河北医药,2016,38(12):1799-1802.
[7] Chakravarti A, Delaney MA, Noll E, et al. Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas [J]. Clin Cancer Res, 2001, 7(8): 2387-2395.
[8] Komatsu K, Nakanishi Y, Nemoto N, et al. Expression and quantitative analysis of matrix metalloproteinase-2 and -9 in human gliomas [J]. Brain Tumor Pathol, 2004, 2l: 105- 112.
[9] Liu MF, Hu YY, Jin T, et al. Matrix metalloproteinase-9/ neutrophil gelatinase associated lipocalin complex activity in human glioma samples predicts tumor presence and clinical prognosis [J]. Dis Markers, 2015, 2015: 138974.
[10] 胡慧敏,刘彦伟,江 涛. 恶性增殖和浸润性生长相关分 子变化在胶质瘤不同病理学分型中的差异[J]. 中华神经 外科杂志,2016,32(6):619-624.
[11] 周长胜,丁 鹏,王崇谦,等. TGF-β1、Ki67、uPA在胶质 瘤中的表达及意义[J]. 华中科技大学学报(医学版), 2013,42(4):432-437.
[12] 高建洲,孔 昕,郭 艳,等. MMP-9和uPA在脑胶质瘤 中的阳性表达及意义[J]. 山东医药,2013,53(5):62-64.
[13] Ma C, Li Y, Zhang X, et al. Levels of vascular endothelial growth factor and matrix metalloproteinase-9 proteins in patients with glioma [J]. J Int Med Res, 2014, 42: 198-204.
[14] 孙文栋,李春晖. 不同级别胶质瘤MMP-9、E-cad、nm23 的表达变化 [J]. 中国临床神经外科杂志,2013,18(11): 677-680.
[15] 李永明,李海洋,李 玉. 基质金属蛋白酶-9和血管内皮 生长因子在人脑胶质瘤中的表达及意义[J]. 中华实验外 科杂志,2013,30(11):2420-2421.
[16] 刘 伟,王长坤,只达石. 胶质瘤浸润组织中MMP-2、 MMP-9、VEGF、Flk-1P16的表达及其临床意义[J]. 吉林 大学学报(医学版),2012,38(4):770-774.

备注/Memo

备注/Memo:
基金项目:武汉市卫计委科研项目(WX14C24);长江航运管理局科技项目(201410010)
更新日期/Last Update: 1900-01-01