[1]李　斐　陈谦学　柳再明　叶　晖　周　龙.颅内动脉瘤破裂并发脑内血肿的危险因素[J].中国临床神经外科杂志,2019,(05):266-268.[doi:10.13798/j.issn.1009-153X.2019.05.003]
　LI Fei,CHEN Qian-xue,LIU Zai-ming,et al.Risk factors of intracranial aneurysm rupture complicated with intracerebral hematoma[J].,2019,(05):266-268.[doi:10.13798/j.issn.1009-153X.2019.05.003]
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颅内动脉瘤破裂并发脑内血肿的危险因素()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年05期
页码:
266-268
栏目:
论著
出版日期:
2019-05-27

文章信息/Info

Title:
Risk factors of intracranial aneurysm rupture complicated with intracerebral hematoma
文章编号:
1009-153X（2019）05-0266-03
作者:
李　斐　陈谦学　柳再明　叶　晖　周　龙
430060 武汉，武汉大学人民医院神经外科（李　斐、陈谦学、柳再明、叶　晖、周　龙）
Author(s):
LI Fei;  CHEN Qian-xue;  LIU Zai-ming;  YE Hui;  ZHOU Long
Department of Neurosurgery, Renmin Hospital, Wuhan University, Wuhan 430060, China
关键词:
颅内动脉瘤; 蛛网膜下腔出血; 脑内血肿; 危险因素
Keywords:
Intracranial aneurysm;  Subarachnoid hemorrhage;  Intracerebral hematomas;  Risk factor
分类号:
R 743.9
DOI:
10.13798/j.issn.1009-153X.2019.05.003
文献标志码:
A
摘要:
目的 探讨颅内动脉瘤破裂并发脑内血肿（ICH）的危险因素。方法 回顾性分析2014年9月至2018年9月收治的颅内破裂动脉瘤425例的临床资料，采用多因素Logistic回归分析检验并发ICH的危险因素，采用受试者工作特征（ROC）曲线分析影响因素截断值。结果 425例中，合并ICH 107例。多因素Logistic回归分析显示，合并高血压、合并糖尿病、动脉瘤位于大脑前动脉及大脑中动脉、动脉瘤直径较大是合并ICH的独立危险因素（P<0.05）。ROC曲线分析显示以动脉瘤直径=1.1 cm预测颅内动脉瘤破裂合并ICH的曲线下面积为0.736，灵敏度为78.3%，特异度为64.1%。结论 合并高血压、合并糖尿病、动脉瘤位于大脑前及大脑中动脉，以及动脉瘤直径在1.1 cm以上的颅内动脉瘤病人，一旦动脉瘤破裂，合并ICH风险较高，临床注意防治。
Abstract:
ObjectiveToexploretheriskfactorsofintracranialaneurysmrupturecomplicatedwithintracerebralhematoma(ICH).MethodsTheclinicaldataof425patientswithrupturedintracranialaneurysmwhowerehospitalizedfromSeptember,2007toSeptember,2018wereanalyzedretrospectively.TheriskfactorsofintracranialaneurysmrupturecomplicatedwithICHwereanalyzedbymultivariateLgisticregression.Thebestcut-offvaluesofriskfactorswereanalyzedbyreceiveroperatorcharacteristic(ROC)curve.ResultsOf425patientswithrupturedintracranialaneurysm,107patientswerecomplicatedwithICH.ThemultivariateLogisticregressionanalysisshowedthattheindependentriskfactorsofintracranialaneurysmrupturecomplicatedwithICHincluedhypertension,diabetes,aneurysmslocatingatmiddleandanteriorcerebralarteries,andthediameterofaneurysm(P<0.05).TheROCcurveanalysisshowedthebestcut-offvalueofthediameterofaneurysmtopredicttheintracranialaneurysmrupturecomplicatedwithICHwas1.1cm,ofwhichtheareaundercurvewas0.736,thesensitivitywas78.3%andthespecificitywas64.1%.ConclusionsThecloseattentionshouldbepaidtotheintracranialaneurysmpatientswhoareassociatedwithhypertension,diabetes,aneurysmslocatingattheanteriorandmiddlecerebralarteries,andintracranialaneurysmdiametermorethan1.1cm,becausetheyhavehighriskofdevelopingICHaftertheintracranialaneurysmrupture.

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备注/Memo

备注/Memo:
基金项目：湖北省自然科学基金（2018CFB604）
作者单位：430060 武汉，武汉大学人民医院神经外科（李　斐、陈谦学、柳再明、叶　晖、周　龙）
通讯作者：陈谦学，E-mail：chenqx666@sohu.com
更新日期/Last Update: 2019-05-27