参考文献/References:
[1] Deschepper CF, Bigornia V, Berens ME, et al. Production of
thrombin and antithrombin Ⅲ by brain and astroglial cell
cultures [J]. Brain Res Mol Brain Res, 1991, 11: 355-358.
[2] Dihanich M, Kaser M, Reinhard E, et al. Prothrombin
mRNA is expressed by cells of the nervous system [J].
Neuron, 1991, 6(4): 575-581.
[3] Jamison CS, Degen SJ. Prenatal and postnatal expression of
mRNA coding for rat prothrombin [J]. Biochim Biophys
Acta, 1991, 1088(2): 208-216.
[4] Yamada T, Nagai Y. Immunohistochemical studies of human
tissues with antibody to factor Xa [J]. Histochem J, 1996, 28
(1): 73-77.
[5] Shikamoto Y, Morita T. Expression of factor X in both the
rat brain and cells of the central nervous system [J]. FEBS
Lett, 1999, 463(3): 387-389.
[6] Hua Y, Xi G, Keep RF, et al. Plasminogen activator inhibi-
tor-1 induction after experimental intracerebral hemorrhage
[J]. J Cereb Blood Flow Metab, 2002, 22(1): 55-61.
[8] 贾文志. 脑出血大鼠血肿周围脑组织 PN-1、thrombin、
PAR-1的表达变化及其相关性[J]. 山东医药，2016，56
（29）：36-38.
[9] Striggow F, Riek-Burchardt M, Kiesel A, et al. Four diffe-
rent types of protease-activated receptors are widely expre-
ssed in the brain and are up-regulated in hippocampus by
severe ischemia [J]. Eur J Neurosci, 2001, 14(4): 595-608.
[10] Weinstein JR, Gold SJ, Cunningham DD, et al. Cellular
localization of thrombin receptor mRNA in rat brain:
expression by mesencephalic dopaminergic neurons and
codistribution with prothrombin mRNA [J]. J Neurosci,
1995, 15(4): 2906-2919.
[11] Jamison C S, Degen S J. Prenatal and postnatal expression
of mRNA coding for rat prothrombin [J]. Biochim Biophys
Acta, 1991, 1088(2): 208-216.
[12] Lyden P, Pereira B, Chen B, et al. Direct thrombin inhibitor
argatroban reduces stroke damage in 2 different models [J].
Stroke, 2014, 45(3): 896-899.
[13] Kameda K, Kikkawa Y, Hirano M, et al. Combined argatro-
ban and anti-oxidative agents prevents increased vascular
contractility to thrombin and other ligands after subarach-
noid haemorrhage [J]. Br J Pharmacol, 2012, 165: 106-119.
[14] Akiyama H, Ikeda K, Kondo H, et al. Thrombin accumula-
tion in brains of patients with Alzheimer’s disease [J].
Neurosci Lett, 1992, 146(2): 152-154.
[15] Lee DY, Park KW, Jin BK. Thrombin induces neurodegene-
ration and microglial activation in the cortex in vivo and in
vitro: proteolytic and non-proteolytic actions [J]. Biochem
Biophys Res Commun, 2006, 346(3): 727-738.
[16] Lee K R, Drury I, Vitarbo E, et al. Seizures induced by in-
tracerebral injection of thrombin: a model of intracerebral
hemorrhage [J]. J Neurosurg, 1997, 87(1): 73-78.
[17] Gingrich M B, Junge C E, Lyuboslavsky P, et al. Potentiation
of NMDA receptor function by the serine protease thrombin
[J]. J Neurosci, 2000, 20(12): 4582-4595.
[18] Rao H V, Thirumangalakudi L, Desmond P, et al. Cyclin
D1, cdk4, and Bim are involved in thrombin-induced
apoptosis in cultured cortical neurons [J]. J Neurochem,
2007, 101(2): 498-505.
[19] Fujimoto S, Katsuki H, Kume T, et al. Thrombin-induced
delayed injury involves multiple and distinct signaling
pathways in the cerebral cortex and the striatum in organo-
typic slice cultures [J]. Neurobiol Dis, 2006, 22: 130-142.
[20] Karabiyikoglu M, Hua Y, Keep RF, et al. Intracerebral hiru-
din injection attenuates ischemic damage and neurologic
deficits without altering local cerebral blood flow [J]. J
Cereb Blood Flow Metab, 2004, 24(2): 159-166.
[21] Wu X, Zhang W, Li JY, et al. Induction of apoptosis by
thrombin in the cultured neurons of dorsal motor nucleus of
the vagus [J]. Neurogastroenterol Motil, 2011, 23(3): 279-
285, e123-e124.
[22] Mirante O, Price M, Puentes W, et al. Endogenous protease
nexin-1 protects against cerebral ischemia [J]. Int J Mol
Sci, 2013, 14(8): 16719-16731.
[23] 郑秋月，陈应柱. 凝血酶在脑出血后白质损伤中的作用及
其机制[J]. 国际脑血管病杂志, 2017, 25(5): 449-453.
[24] Striggow F, Riek M, Breder J, et al. The protease thrombin is
an endogenous mediator of hippocampal neuroprotection
against ischemia at low concentrations but causes degene-
ration at high concentrations [J]. Proc Natl AcadSci U S A,
2000, 97(5): 2264-2269.
[25] Xi G, Keep RF, Hua Y, et al. Attenuation of thrombin-
induced brain edema by cerebral thrombin preconditioning
[J]. Stroke, 1999, 30(6): 1247-1255.
[26] Henrich-Noack P, Striggow F, Reiser G, et al. Precondition-
ing with thrombin can be protective or worsen damage after
endothelin-1-induced focal ischemia in rats [J]. J Neurosci
Res, 2006, 83(3): 469-475.
[27] Wang H, Reiser G. Thrombin signaling in the brain: the
role of protease-activated receptors [J]. Biol Chem, 2003,
384(2): 193-202.
[28] Macfarlane SR, Seatter MJ, Kanke T, et al. Proteinase-acti-
vated receptors [J]. Pharmacol Rev, 2001, 53(2): 245-282.
[29] Nakamura T, Keep RF, Hua Y, et al. Intracerebral hemor-
rhage induces edema and oxidative stress and alters N-
methyl-D-aspartate receptor subunits expression [J]. Acta
Neurochir Suppl, 2005, 95: 421-424.
[30] Granziera C, Thevenet J, Price M, et al. Thrombin-induced
ischemic tolerance is prevented by inhibiting c-jun N-
terminal kinase [J]. Brain Res, 2007, 1148: 217-225.