[1]孙瑞迅 李琳坤 董 辉 刘 飒.脑胶质瘤病人SII、血清Fib和AGR水平变化及意义[J].中国临床神经外科杂志,2020,(04):209-211.[doi:10.13798/j.issn.1009-153X.2020.04.006]
 SUN Rui-xun,LI Lin-kun,DONG Hui,et al.Changes of SII, serum levels of Fib and AGR and their clinical significances in patients with gliomas[J].,2020,(04):209-211.[doi:10.13798/j.issn.1009-153X.2020.04.006]
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脑胶质瘤病人SII、血清Fib和AGR水平变化及意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2020年04期
页码:
209-211
栏目:
论著
出版日期:
2020-04-30

文章信息/Info

Title:
Changes of SII, serum levels of Fib and AGR and their clinical significances in patients with gliomas
文章编号:
1009-153X(2020)04-0209-03
作者:
孙瑞迅 李琳坤 董 辉 刘 飒
473300 河南,南阳市第二人民医院神经外科(孙瑞迅、李琳坤、董 辉、刘 飒)
Author(s):
SUN Rui-xun LI Lin-kun DONG Hui LIU Sa.
Department of Neurosurgery, The Second People’s Hospital of Nanyang City, Nanyang 473300, China
关键词:
脑胶质瘤全身免疫炎症指数纤维蛋白原白蛋白/球蛋白比值血清
Keywords:
Human glioma Systemic immunoinflammatory index Fibrinogen Albumin/Globulin Ratio Serum
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2020.04.006
文献标志码:
A
摘要:
目的 探讨脑胶质瘤病人全身免疫炎症指数(SII)、血清纤维蛋白原(Fib)、血清白蛋白/球蛋白比值(AGR)水平变化及临床意义。方法 回顾性分析2012年12月至2017年7月收治的128例脑胶质瘤的临床资料,以同期健康体检者68例为对照组。SII为外周静脉血液中性粒细胞和血小板的乘积与淋巴细胞的比值。结果 脑胶质瘤病人SII、血清Fib水平明显高于对照组(P<0.05),而血清AGR明显低于对照组(P<0.05)。SII、血清Fib与胶质瘤病理级别呈明显正相关(P<0.05),而血清AGR胶质瘤病理级别呈明显负相关(P<0.05)。ROC曲线结果示,对判断胶质瘤恶性程度:SII曲线下面积为0.757,敏感度和特异度分别为0.844和0.789;血清Fib曲线下面积为0.706,敏感度和特异度分别为0.875和0.737;血清AGR曲线下面积为0.715,敏感度和特异度分别为0.813和0.632;三者联合检测曲线下面积为0.875,敏感度和特异度分别为0.906和0.842。结论 脑胶质瘤病人SII、血清Fib水平升高,而血清AGR水平降低;三者水平变化对脑胶质瘤恶性程度具有一定的诊断价值。
Abstract:
Objective To investigate the changes of systemic immunoinflammatory index (SII), serum fibrinogen (Fib), and serum albumin/globulin ratio (AGR) in the patients with gliomas and their clinical significances. Methods The clinical data of 128 patients with brain gliomas who were admitted to our hospital from December, 2012 to July, 2017 were retrospectively analyzed. Sixty-eight healthy subjects were served as the control group. SII was the ratio of the product of peripheral venous blood neutrophils and platelets to lymphocytes. Results The levels of SII and serum Fib in the patients with glioma were significantly higher than those in the control group (P<0.05), while the serum AGR was significantly lower than that in the control group (P<0.05). The SII and serum Fib were significantly positively correlated with the glioma pathological grade (P<0.05), while the serum AGR was significantly negatively correlated with the glioma pathological grade (P<0.05). The results of the ROC curve showed that, for assessing the malignant degree of glioma, the area under cueve (AUC) of SII was 0.757, with a sensitivity of 0.844 and a specificity of 0.789, respectively; the AUC of serum Fib was 0.706, with a sensitivity of 0.875 and a specificity of 0.737, respectively; the AUC of serum AGR was 0.715, with a sensitivity of 0.813 and a specificity of 0.632, respectively; the AUC of the combination of these three factors was 0.875, with a sensitivity of 0.906 and a specificity of 0.842, respectively. Conclusion The levels of SII and serum Fib in patients with gliomas increase, while the level of serum AGR decreases. The changes in the levels of these three factors have certain diagnostic value for the glioma.

参考文献/References:

[1] Wu C, Su J, Wang X, et al. Overexpression of the phospholi-pase A2 group V gene in glioma tumors is associated with poor patient prognosis [J]. Cancer Manag Res, 2019, 11: 3139-3152.
[2] 杜金龙. 长链非编码RNA DANCR在神经胶质瘤中的表达水平和临床意义[J]. 山西医科大学学报,2019,50(2):210-214.
[3] 张佩佩,曾 强,黄 宁,等. 动态对比增强MRI在脑胶质瘤分级中计算模型的选择及应用研究[J]. 中华放射学杂志,2017,49(13):1341-1344.
[4] 张立志,刘 平,吉慧军,等. 全身免疫炎症指数(SII)对胶质瘤患者临床预后的影响及与P53突变的关系[J]. 现代肿瘤医学,2018,26(24):3937-3943.
[5] 李 巍,王雅茹,宋 雯,等. 胶质瘤患者凝血指标的变化及其与胶质瘤恶性程度相关性分析[J]. 中华医学杂志,2018,98(5):336-339.
[6] Tomita M, Ayabe T, Maeda R, et al. Systemic immune-inflammation index predicts survival of patients after cura-tive resection for non-small cell lung cancer [J]. In Vivo, 2018, 32: 663-667.
[7] Perisanidis C, Psyrri A, Cohen EE, et al. Prognostic role of pretreatment plasma fbrinogen in patients with solid tumors:a systematic review and meta-analysis [J]. Cancer Treat Rev, 2015, 41: 960-970.
[8] Candido J, Hagemann T. Cancer-related inflammation [J]. J Clin Immunol, 2013, 33(S1): S79-S84.
[9] Borg N, Guilfoyle MR, Greenberg DC, et al. Serum albumin and survival in glioblastoma multiforme [J]. J Neurooncol, 2011, 105: 77-81.
[10] Ostrom QT, Bauchet L, Davis FG, et al. The epidemiology of glioma in adults: a ’state of the science’ review [J]. Neuro Oncol, 2014, 16: 896-913.
[11] Wang JL, Xiao WJ, Chen WY, et al. Prognostic significance of preoperative neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with glioma [J]. EXCLI J, 2018, 17: 505-512.
[12] Kemerdere R, Akgun MY, Toklu S, et al. Preoperativesystemic inflammatory markers in low- and high-grade gliomas: a retrospective analysis of 171 patients [J]. Heliyon, 2019, 5(5): e01681.
[13] Gao YB, Guo W, Cai SH, et al. Systemic immune-inflam-mation index (SII) is useful to predict survival outcomes in patients with surgically resected esophageal squamous cell carcinoma [J]. J Cancer, 2019, 10: 3188-3196.
[14] Stanger BZ, Kahn ML. Platelets and tumor cells: a new form of border control [J]. Cancer Cell, 2013, 24: 9-11.
[15] Adams GN, Rosenfeldt L, Frederick M, et al. Colon cancer growth and dissemination relies upon thrombin, stromal PAR-1, and fibrinogen [J]. Cancer Res, 2015, 75: 4235-4243.
[16] Martino MM, Briquez PS, Ranga A, et al. Heparin-binding domain of fibrin(ogen)binds growth factors and promotes tissue repair when incorporated within a synthetic matrix [J]. Proc Natl Acad Sci USA, 2013, 110(12): 4563-4568.
[17] 郝 玮,郭彩虹,李 莉,等. 老年非小细胞肺癌患者血浆D-二聚体与纤维蛋白原的临床意义及其与化疗的关系[J]. 国际检验医学杂志,2015,36(23):3472-3475.
[18] 李生平,周业江. 手术前后白蛋白与球蛋白比值变化对结肠癌预后的评估价值[J]. 实用医学杂志,2019,35(5):783-388.
[19] 范仕兵,冉住国,李 骥,等. 术前血清白蛋白与球蛋白比值与脑胶质母细胞瘤预后的相关性[J]. 中国神经精神疾病杂志,2018,44(7):412-418.
[20] 张海茂,赵风雪,田可港,等. 急性白血病患者血浆D-二聚体、血管性血友病因子、抗凝血酶Ⅲ、纤维蛋白原水平表达及意义[J]. 国际检验医学杂志,2018,39(17):2126-2130.

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备注/Memo

备注/Memo:
(2019-12-12收稿,2019-12-24修回)
更新日期/Last Update: 2020-04-10