[1]刘　瀛　耿荣鑫　吴明洪　朱晓楠　徐海涛.人脑胶质瘤组织BIRC2表达变化及临床意义[J].中国临床神经外科杂志,2021,26(05):333-335.[doi:10.13798/j.issn.1009-153X.2021.05.005]
　LIU Ying,GENG Rong-xin,WU Ming-hong,et al.Expression of BIRC2 in human glioma tissues and its clinical significance[J].,2021,26(05):333-335.[doi:10.13798/j.issn.1009-153X.2021.05.005]
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人脑胶质瘤组织BIRC2表达变化及临床意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
26
期数:
2021年05期
页码:
333-335
栏目:
论著
出版日期:
2021-05-25

文章信息/Info

Title:
Expression of BIRC2 in human glioma tissues and its clinical significance
文章编号:
1009-153X（2021）05-0333-03
作者:
刘　瀛　耿荣鑫　吴明洪　朱晓楠　徐海涛
437199 湖北咸宁，湖北科技学院（刘　瀛）；430060 武汉，武汉大学人民医院神经外科（耿荣鑫、吴明洪、朱晓楠、徐海涛）
Author(s):
LIU Ying1;  GENG Rong-xin2;  WU Ming-hong2;  ZHU Xiao-nan2;  XU Hai-tao2.
1. Hubei University of Science and Technology, Xianning 437199, China; 2. Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China
关键词:
人脑胶质瘤; BIRC2; 基因表达; 生物信息学
Keywords:
Glioma;  Gene expression;  BIRC2;  Bioinformatics
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2021.05.005
文献标志码:
A
摘要:
目的 探讨人脑胶质瘤组织含杆状病毒IAP重复蛋白2（BIRC2）表达变化及临床意义。方法 从GEO数据库获取人脑胶质瘤的基因表达芯片进行差异表达基因分析，并借助TCGA数据库对筛选出的BIRC2基因在人脑胶质瘤中的表达及预后进行分析，同时通过GSEA分析BIRC2在人脑胶质瘤中的作用机制进行预测。结果 从GEO数据库筛选GSE66354芯片中筛选出BIRC2为上调表达基因。TCGA数据库分析结果表明，BIRC2在多形性胶质母细胞瘤中的表达显著高于正常脑组织（P<0.05），预后分析表明BIRC2高表达胶质瘤病人预后更差（P<0.05），GSEA分析显示BIRC2的作用主要发生在蛋白质翻译启动等过程。结论 本文结果提示BIRC2可能与人脑胶质瘤的发生、发展有关，检测BIRC2基因可用于评估人脑胶质瘤病人预后。
Abstract:
Objective To explore the expression of baculoviral IAP repeat containing 2 (BIRC2) in human glioma tissues and its clinical meaning. Methods The gene expression chip of human glioma obtained from the GEO database was used to analyze the differentially expressed genes. The TCGA database was used to analyze the relationship between the expression level of selected BIRC2 gene and the prognosis of human glioma patients. GSEA analysis was used predict the mechanism of BIRC2 in human glioma. Results BIRC2 was selected as an up-regulated gene from geneset GSE66354. TCGA database analysis results showed that the expression of BIRC2 in glioblastoma tissues is significantly higher than that of normal brain tissues (P<0.05). Prognostic analysis showed that patients with high-expression BIRC2 glioma had worse prognosis. GSEA analysis showed that the role of BIRC2 mainly occurred in the process of protein translation initiation. Conclusion The results suggest that BIRC2 may be related to the occurrence and development of human glioma, and the BIRC2 gene can be used to evaluate the prognosis of human glioma patients.

参考文献/References:

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备注/Memo

备注/Memo:
通讯作者：徐海涛，E-mail：xuhaitaorenmin@163.com
更新日期/Last Update: 2021-05-25