[1]王丽娜,张育磊,黄可.利伐沙班联合氯吡格雷在房颤病人颈动脉支架置入术后的应用[J].中国临床神经外科杂志,2022,27(10):850-852.[doi:10.13798/j.issn.1009-153X.2022.10.015]
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利伐沙班联合氯吡格雷在房颤病人颈动脉支架置入术后的应用()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年10期
页码:
850-852
栏目:
经验介绍
出版日期:
2022-10-31

文章信息/Info

文章编号:
1009-153X(2022)10-0850-03
作者:
王丽娜张育磊黄可
471000河南洛阳,河南科技大学第一附属医院介入科(王丽娜、黄可),神经外科(张育磊)
关键词:
颈动脉狭窄房颤颈动脉支架置入术缺血性卒中利伐沙班氯吡格雷阿司匹林
分类号:
R743;R815.2
DOI:
10.13798/j.issn.1009-153X.2022.10.015
文献标志码:
B
摘要:
目的 探讨利伐沙班联合氯吡格雷在房颤病人颈动脉支架置入术后的应用效果。方法 回顾性分析2015年1月至2022年3月行颈动脉支架置入术治疗的148例颈动脉狭窄合并房颤的临床资料。结果 术后应用阿司匹林联合氯吡格雷79例(对照组),利伐沙班联合氯吡格雷69例(观察组)。对照组年龄明显偏大(P<0.05),CHAsDS2-VASc评分明显偏低(P<0.05),吸烟史比例较低(P<0.05),合并糖尿病比例偏大(P<0.05)。术后3个月随访显示,观察组术后缺血性卒中发生率明显低于对照组(20.2% vs 8.7%;P<0.05),而两组出血发生率无统计学差异(P>0.05)。多因素Cox回归分析显示,利伐沙班联合氯吡格雷是术后发生缺血性卒中的保护因素(HR=0.83;95% CI 0.67~0.93;P=0.032)。结论 房颤病人颈动脉支架置入术后应用利伐沙班联合氯吡格可降低术后缺血性卒中发生率,不增加出血风险。

参考文献/References:

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备注/Memo

备注/Memo:
(2021-07-28收稿,2021-10-30修回)
更新日期/Last Update: 2022-11-30