[1]罗 谦 姜 曙 周培志 蔡博文.培维索孟治疗肢端肥大症疗效的系统评价[J].中国临床神经外科杂志,2015,(10):591-593.[doi:10.13798/j.issn.1009-153X.2015.10.005]
 LUO Qian,JIANG Shu,ZHOU Pei-zhi,et al.Curative effect of pegvisomant on acromegaly: a systematic review[J].,2015,(10):591-593.[doi:10.13798/j.issn.1009-153X.2015.10.005]
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培维索孟治疗肢端肥大症疗效的系统评价()

《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年10期
页码:
591-593
栏目:
论著
出版日期:
2015-10-30

文章信息/Info

Title:
Curative effect of pegvisomant on acromegaly: a systematic review
文章编号:
1009-153X(2015)10-0591-03
作者:
罗 谦 姜 曙 周培志 蔡博文
610041 成都,四川大学华西医院神经外科
通讯作者:蔡博文,E-mail:746077865@qq.com
Author(s):
LUO Qian JIANG Shu ZHOU Pei-zhi CAI Bo-wen.
Department of Neurosurgery, Huaxi Hospital, Sichuan University, Chengdu 610041, China
关键词:
垂体生长激素腺瘤肢端肥大症培维索孟疗效系统评价
Keywords:
Pegvisomant Acromegaly Randomized controlled trial Systematic review
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2015.10.005
文献标志码:
A
摘要:
目的 评价培维索孟治疗肢端肥大症的疗效和安全性。方法 系统性检索Cochrane Library、Medline、Embase、中国知网、维普等数据库,对培维索孟治疗肢端肥大症的疗效和安全性进行描述性的系统评价。结果 ①培维索孟能缓解患者部分症状;②培维索孟能使患者血清胰岛素生长因子-1(IGF-1)明显降低,同时生长激素可能升高;③培维索孟不影响肿瘤大小;④培维索孟短期不良反应较少。结论 培维索孟能改善肢端肥大症患者的症状,有效降低血清IGF-1水平,短期使用有较好的安全性。
Abstract:
Objective To evaluate the effectiveness and safety of treatment of acromegaly with pegvisomant. Methods The databases including Cochrane Library, Medline, EMbase, CNKI and VIP were searched to collect randomized controlled trials of treatment of acromegaly with pegvisomant. The effectiveness and safety of pegvisomant for acromegaly were reviewed by narrative synthesis. Results ① The signs and symptoms could be improved by pegvisomant in the patients with acromegaly. ② The serum level of insulin-like growth factor (IGF-1) could be significantly reduced and the serum level of growth hormone could be significantly increased by pegvisomant. ③The pituitary growth hormone-secreting adenomas volume were unchanged after treatment with pegvisomant in the patients with acromegaly. Conclusion Pegvisoment may effectively reduce serum IGF-1 levels and improve the signs and symptoms in the patients with acromegaly. The short-term use of pegvisomant is safe in the patients with acromegaly.

参考文献/References:

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[3] Trainer PJ, Drake WM, Katznelson L, et al. Treatment of acromegaly with the growth hormone-receptor antagonist pegvisomant [J]. N Engl J Med, 2000, 342(16): 1171-1177.
[4] Sesmilo G, Fairfield WP, Katznelson L, et al. Cardiovascular risk factors in acromegaly before and after normalization of serum IGF-I levels with the GH antagonist pegvisomant [J]. J Clin Endocrinol Metab, 2002, 87(4): 1692-1699.
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[8] VanderLely AJ, Hutson RK, Trainer PJ, et al. Long-term treatment of acromegaly with pegvisomant, agrowth hormone receptor antagonist [J]. Lancet, 2001, 358: 1754-1759.
[9] Colao A, Pivonello R, Auriemma RS, et al. Efficacy of 12- month treatment with the GH receptor antagonistpegviso- mant in patients with acromegaly resistant to long-term, high-dose somatostatin analog treatment: effect on IGF-I levels, tumor mass, hypertension and glucose tolerance [J]. Eur J endocrinol, 2006, 154: 467-477.
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备注/Memo

备注/Memo:
基金项目:四川省科技厅科技支撑计划(2014SZ0019-9;2015SZ0120)
更新日期/Last Update: 2015-10-30