[1]田　君　朱秀梅　李　琦　池丽燕　魏梁锋　郑兆聪　王守森.2011~2013年我院NICU革兰阴性杆菌耐药性分析[J].中国临床神经外科杂志,2016,(07):422-424.[doi:10.13798/j.issn.1009-153X.2016.07.011]
　TIAN Jun,ZHU Xiu-mei,LI Qi,et al.Drug resistance of Gram-negative Bacilli in patients in NICU from 2011 to 2013[J].,2016,(07):422-424.[doi:10.13798/j.issn.1009-153X.2016.07.011]
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2011~2013年我院NICU革兰阴性杆菌耐药性分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年07期
页码:
422-424
栏目:
论著
出版日期:
2016-07-15

文章信息/Info

Title:
Drug resistance of Gram-negative Bacilli in patients in NICU from 2011 to 2013
文章编号:
1009-153X（2016）07-0422-03
作者:
田　君　朱秀梅　李　琦　池丽燕　魏梁锋　郑兆聪　王守森
350025 福州，南京军区福州总医院神经外科）
通讯作者：王守森，E-mail：wshsen@126.com
Author(s):
TIAN Jun;  ZHU Xiu-mei;  LI Qi;  CHI Li-yan;  WEI Liang-feng;  ZHENG Zhao-cong;  WANG Shou-sen
Department of Neurosurgery, Fuzhou General Hospital, Nanjing Command, PLA, Fuzhou 350025, China
关键词:
神经外科重症监护病房; 革兰阴性杆菌; 耐药性
Keywords:
Neurosurgery;  Intensive care unit;  Gram-negative bacilli;  Drug resistance
分类号:
R 651; R 446.5
DOI:
10.13798/j.issn.1009-153X.2016.07.011
文献标志码:
A
摘要:
目的 总结分析近3年我院神经外科重症监护病房（NICU）患者的标本革兰阴性杆菌耐药性变化趋势，以指导临床合理使用抗菌药物。方法 分析2011年1月至2013年 12月NICU内患者的标本中分离出革兰阴性杆菌，采用最低抑菌浓度法对所检出细菌进行药敏检测，并用WHONET 5.3软件进行数据分析。结果 共检出363株革兰阴性杆菌，占前3位的为不动杆菌属（34.7%）、铜绿假单胞菌（24.5%）及肺炎克雷伯菌（20.4%）；不动杆菌属对阿米卡星和头孢哌酮/舒巴坦的耐药率最低，分别为4.0%和15.9%。铜绿假单胞菌对哌拉西林/他唑巴坦耐药性约33.3%。肺炎克雷伯菌除了对碳青霉烯类耐药性降低外，对其他抗菌素耐药性有增多趋势。结论 在NICU革兰阴性杆菌中，亚胺培南、头孢哌酮/舒巴坦与哌拉西林/他唑巴坦对革兰阴性杆菌具有很好的敏感性。
Abstract:
Objective To study the drug resistance of Gram-negative bacilli in the patients in neurosurgery intensive care unit (NICU) in order to provide guidance for the rational use of antibiotics. Method From January, 2011 to December, 2013, the antimicrobial susceptibility test was performed in the Gram-negative bacilli isolated from the patients in NICU by minimum inhibitory concentration method. The Results were analyzed by WHONET 5.3 Software. Results The first three pathogens of 363 strains were Acinetobacter spp (34.7%), Pseudomonas aeruginosa (24.5%) and Klebsiella pneumonia (20.4%) respectively. The resistance rate of Acinetobacter spp to amikacin and cefoperazone-sulbactam were 4.0% and 15.9% respectively. The resistance rate of pseudomonas aeruginosa to piperacillin-tazobactam was about 33.3%. Conclusions In NICU, imipenem cefoperazone-sulbactam and piperacillin-tazobactam remain high activity against Gram-negative bacilli in NICU.

参考文献/References:

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更新日期/Last Update: 1900-01-01