[1]孙衍昶　刘达远　许鹏翔　欧阳一彬　莫业和.星形细胞瘤FLI-1蛋白表达及其与病人预后的关系[J].中国临床神经外科杂志,2022,27(04):266-268.[doi:10.13798/j.issn.1009-153X.2022.04.008]
　SUN Yan-chang,LIU Da-yuan,XU Peng-xiang,et al.Expression of FLI-1 protein in astrocytoma and its clinical meanings[J].,2022,27(04):266-268.[doi:10.13798/j.issn.1009-153X.2022.04.008]
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星形细胞瘤FLI-1蛋白表达及其与病人预后的关系()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
27
期数:
2022年04期
页码:
266-268
栏目:
论著
出版日期:
2022-04-30

文章信息/Info

Title:
Expression of FLI-1 protein in astrocytoma and its clinical meanings
文章编号:
1009-153X（2022）04-0266-03
作者:
孙衍昶　刘达远　许鹏翔　欧阳一彬　莫业和
570100 海口，海南医学院第二附属医院神经外科（孙衍昶、刘达远、许鹏翔、欧阳一彬、莫业和）
Author(s):
SUN Yan-chang;  LIU Da-yuan;  XU Peng-xiang;  OUYANG Yi-bin;  MO Ye-he.
Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical University, Haikou 570100, China
关键词:
星形细胞瘤; Friend白血病整合素 1转录因子; FLI-1; 预后; 基因表达; 危险因素
Keywords:
Astrocytoma;  Friend leukemia integration 1 transcription factor;  FLI-1 protein;  Prognosis;  Risk factors
分类号:
R 739.41; Q 786
DOI:
10.13798/j.issn.1009-153X.2022.04.008
文献标志码:
A
摘要:
目的 探讨星形细胞瘤Friend白血病整合素1转录因子（FLI-1）表达水平及其与病人预后的关系。方法 选取2015年6月~2018年6月手术切除的术后病理检查确诊的星形细胞瘤标本112例和颅脑损伤内减压术获得非肿瘤脑组织59例（对照组），采用免疫组织化学染色法检测FLI-1表达情况。术后随访3年，记录无进展生存、总生存情况，其中无进展生存为预后良好，肿瘤进展或病人死亡为预后不良。结果 112例星形细胞瘤中，预后良好62例，预后不良50例。星形细胞瘤FLI-1表达阳性率[66.96%（75/112）]明显高于对照组[16.95%（10/59）；P<0.05]。星形细胞瘤FLI-1表达与IDH1表达呈明显负相关（r=-0.682，P<0.001），与p53表达呈正明显相关（r=0.711，P<0.001）。多因素logistic回归分析显示FLI-1表达阳性是星形细胞瘤预后不良的独立危险因素（OR=3.758 ；95% CI 1.439~9.814 ；P=0.009）。生存曲线分析显示，FLI-1表达阴性病人3年累积无进展生存率（75.68%）、3年累积总生存率（81.08%）均明显高于FLI-1表达阳性的病人（分别为45.33%、49.33%；P<0.05）。结论 星形细胞瘤FLI-1呈高表达，与病人的不良预后有关。
Abstract:
Objective To investigate the expression of Friend leukemia integration 1 transcription factor (FLI-1) protein in the astrocytoma tissues and its clinical meanings. Methods The expression levels of FLI-1 were detected using immunohistochemical staining in astrocytoma tissues obtained from 112 patients with astrocytoma who underwent micorsurgery from June 2015 to June 2018 and in non-tumor cerebral tissues obtained from 59 patients with traumatic brain injury who underwent decompression (control group). The astrocytoma patients were followed up for 3 years, and progression-free survival (PFS) and overall survival (OS) were recorded in which PFS was classified as good prognosis, and tumor progression or death was classified as poor prognosis. Results Of these 112 astrocytoma patients, 62 patients had good prognosis and 50 had poor prognosis. The positive rate of FLI-1 in astrocytoma tissues [66.96% (75/112)] was significantly higher than that [16.95% (10/59)] in the control group (P<0.05). In astrocytoma tissues, FLI-1 expression was significantly negatively correlated with IDH1 expression (r=-0.682, P<0.001), and significantly positively correlated with p53 expression (r=0.711, P<0.001). Multivariate logistic regression analysis showed that positive FLI-1 expression was an independent risk factor for poor prognosis in astrocytoma patients (OR=3.758; 95% CI 1.439~9.814; P=0.009). Survival curve analysis showed that the 3-year cumulative PFS rate (75.68%) and 3-year cumulative OS rate (81.08%) of patients with negative FLI-1 expression were significantly higher than those of patients with positive FLI-1 expression (45.33% and 49.33%, respectively; P<0.05). Conclusions The high expression of FLI-1 in astrocytoma tissues is associated with the poor prognosis of astrocytoma patients.

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备注/Memo

备注/Memo:
基金项目：海南省卫生健康行业科研项目（19A200002）
通讯作者：莫业和，E-mail：xen3040@163.com
更新日期/Last Update: 1900-01-01