[1]陈思,唐忠,王辉,等.AIDS伴颅内占位性病变的立体定向活检术分析[J].中国临床神经外科杂志,2023,28(04):240-242.[doi:10.13798/j.issn.1009-153X.2023.04.004]
　CHEN Si,TANG Zhong,WANG Hui,et al.Application of stereotactic biopsy in patients with AIDS associated with intracranial space-occupying lesions: report of 19 cases[J].,2023,28(04):240-242.[doi:10.13798/j.issn.1009-153X.2023.04.004]
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AIDS伴颅内占位性病变的立体定向活检术分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
28
期数:
2023年04期
页码:
240-242
栏目:
论著
出版日期:
2023-04-30

文章信息/Info

Title:
Application of stereotactic biopsy in patients with AIDS associated with intracranial space-occupying lesions: report of 19 cases
文章编号:
1009-153X（2023）04-0240-03
作者:
陈思; 唐忠; 王辉; 季玮; 周泱; 初明; 彭巧丽; 廖广生; 黄东东; 余凤仪
518112广东，深圳市第三人民医院/南方科技大学第二附属医院神经外科（陈思、唐忠、季玮、初明、廖广生、黄东东、余凤仪），感染一科（王辉、周泱、彭巧丽）
Author(s):
CHEN Si1;  TANG Zhong1;  WANG Hui2;  JI Wei1;  ZHOU Yang2;  CHU Ming1;  PENG Qiao-li2;  LIAO Guang-sheng1;  HUANG Dong-dong1;  YU Feng-yi1
1.Department of Neurosurgery, Third Affiliated Municipal People's Hospital/Second Affiliated College of Southern University of Science and Technology, Shenzhen 518112, China; 2.Department of Infection, Third Affiliated Municipal People's Hospital/Second Affiliated College of Southern University of Science and Technology, Shenzhen 518112, China
关键词:
获得性免疫缺陷综合征; 艾滋病; 颅内占位性病变; 立体定向活检术
Keywords:
Acquired immune deficiency syndrome;  AIDS;  Intracranial space occupying lesion;  Stereotactic biopsy
分类号:
A
DOI:
10.13798/j.issn.1009-153X.2023.04.004
文献标志码:
R739.41;R651.1+1
摘要:
目的 探讨立体定向活检术在获得性免疫缺陷综合征（AIDS）伴颅内占位性病变病人中的应用价值。方法 回顾性分析2017年8月至2021年12月收治的19例AIDS病人伴颅内占位性病变的临床资料，均行立体定向活检术取闹组织进行病理检查。结果 19例中，18例获得确诊，诊断阳性率为94.74%；其中真菌感染7例，肿瘤3例，进行性多病灶脑白质病、HIV脑病2例、结核肉芽肿各2例，弓形虫病、病毒性脑炎各1例。1例（5.26%）术后病理检查诊断不明确。术后出现穿刺道少量出血1例（5.26%），无神经功能障碍，无手术死亡病例。根据活检术后病理结果给予相应治疗，随访4个月~1年，平均6个月，复查颅脑增强MRI显示15例病灶变小、数量减少和（或）周围水肿减少，好转率为78.95%；4例无明显变化。结论 AIDS病人伴发的颅内占位性病理性质多样，立体定向活检术能提供精准的诊断，并具有微创、安全的优点，可为治疗方案的制定提供有效的依据，提高临床治疗效果。
Abstract:
Objective To investigate the application value of stereotactic biopsy in patients with acquired immune deficiency syndrome (AIDS) associated with intracranial space-occupying lesions. Methods The clinical data of 19 patients with AIDS complicated with intracranial space-occupying lesions who underwent stereotactic biopsy from August 2017 to December 2021 were retrospectively analyzed. Results Of 19 patients, 18 patients (94.74%) were definitely diagnosed by postoperative pathological examination, including 7 patients of fungal infection, 3 tumors, 2 progressive multifocal leukoencephalopathy, 2 HIV encephalopathy, 2 tuberculous granuloma, 1 toxoplasmosis and 1 viral encephalitis. One patient did not definitely diagnosed by postoperative pathological examination. A small amount of bleeding in the puncture path occurred in 1 patient (5.26%) after surgery. There were no neurological dysfunction or surgical death. The corresponding treatment was given according to the pathological results after biopsy, and the follow-up ranged from 4 months to 1 year, with an average of 6 months. Contrast enhanced MRI showed that the intracranial lesions were reduced in 15 patients (78.95%), and did not significantly change in 4 patients. Conclusions The pathological results are diverse in AIDS patients with intracranial space-occupying lesions. Stereotactic biopsy can provide accurate diagnosis with the advantages of minimally invasive and safe, which can provide effective basis for the treatment plan and improve treatment effect.

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相似文献/References:

[1]王　蓓.艾滋病患者颅内病变立体定向活检术围手术期护理[J].中国临床神经外科杂志,2016,(08):502.[doi:10.13798/j.issn.1009-153X.2016.08.023]

备注/Memo

备注/Memo:
（2022-04-24收稿，2022-11-28修回）
基金项目：“十三五”国家科技重大项目（2018ZX10302104-001）；广东省深圳市科技计划项目（JCYJ20210324132012035）
通讯作者：唐　忠，E-mail：zhongtang999@163.com
更新日期/Last Update: 2022-04-30