[1]丁慧超,管江衡,谢天浩,等.SEEG引导下RF-TC治疗脑室旁灰质移位症所致药物难治性癫痫（附2例报道并文献复习）[J].中国临床神经外科杂志,2023,28(07):421-424.[doi:10.13798/j.issn.1009-153X.2023.07.002]
　DING Hui-chao,GUAN Jiang-heng,XIE Tian-hao,et al.Clinical efficacy of stereotactic electroencephalogram guided radiofrequency thermocoagulation for refractory epilepsy caused by periventricular gray matter heterotopia: report of 2 case and literature review[J].,2023,28(07):421-424.[doi:10.13798/j.issn.1009-153X.2023.07.002]
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SEEG引导下RF-TC治疗脑室旁灰质移位症所致药物难治性癫痫（附2例报道并文献复习）()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
28
期数:
2023年07期
页码:
421-424
栏目:
论著
出版日期:
2023-07-31

文章信息/Info

Title:
Clinical efficacy of stereotactic electroencephalogram guided radiofrequency thermocoagulation for refractory epilepsy caused by periventricular gray matter heterotopia: report of 2 case and literature review
文章编号:
1009-153X（2023）07-0421-04
作者:
丁慧超; 管江衡; 谢天浩; 李洋; 向露; 吕丽辉; 刘琴; 宋健; 徐国政
430070武汉，中部战区总医院神经外科（丁慧超、管江衡、谢天浩、李洋、向露、吕丽辉、刘琴、宋健、徐国政）
Author(s):
DING Hui-chao;  GUAN Jiang-heng;  XIE Tian-hao;  LI Yang;  XIANG Lu;  LV Li-hui;  LIU Qin;  SONG Jiang;  XU Guo-zheng
Department of Neurosurgery, General Hospital of Central Theater Command, Wuhan 430070, China
关键词:
药物难治性癫痫; 脑室旁灰质移位症; 立体定向脑电图; 射频热凝毁损术; 疗效
Keywords:
Refractory epilepsy;  Paraventricular gray matter heterotopia;  Stereotactic electroencephalography;  Radiofrequency thermocoagulation;  Clinical efficacy
分类号:
A
DOI:
10.13798/j.issn.1009-153X.2023.07.002
文献标志码:
R742.1;R651.1+1
摘要:
目的 探讨立体定向脑电图（SEEG）引导下射频热凝毁损术（RF-TC）治疗脑室旁灰质移位症（GMH）所致药物难治性癫痫的疗效。方法 回顾性分析2例脑室旁GMH所致药物难治性癫痫的临床资料，并结合相关文献进行分析。结果 术前根据临床表现、影像学特表现以及脑电图诊断为脑室旁GMH所致药物难治性癫痫，行机器人辅助SEEG记录精确定位致痫区及传导途径，并在SEEG引导下行RF-TC治疗。所有电极偏差在3 mm误差范围以内，术后未发生手术相关并发症，无神经系统相关并发症。术后随访1年，1例癫痫完全控制，1例癫痫发作频率减少80%。结论 脑室旁GMH是导致药物难治性癫痫的原因之一，SEEG引导下RF-TC治疗的效果良好，是一种安全的、有效的治疗方式。
Abstract:
Objective To explore the clinical efficacy of stereotactic electroencephalography (SEEG) guided radiofrequency thermocoagulation (RF-TC) for patients with refractory epilepsy caused by periventricular gray matter heterotopia (PGMH). Methods A retrospective analysis was performed on the clinical data of two patients with refractory epilepsy caused by PGMH who underwent SEEG guided RF-TC in our department, and the relevant literatures were reviewed. Results Before the surgery, both patients were diagnosed with refractory epilepsy caused by PGMH according to the clinical features, imaging characteristics and video EEG. Robot-assisted SEEG recording was performed to accurately locate the epileptogenic foci and conduction pathways, and RF-TC under SEEG guidance were performed on both patients. All the electrode deviations did not exceed the error range of 3 mm, and there were no operation-related complications or neurological complications. After 1 year of follow-up, the epilepsy of 1 patient was completely controlled, and the seizure frequency was reduced by 80% in the other patient. Conclusions PGMH is one of the causes of drug-resistant epilepsy. SEEG-guided RF-TC is a safe and effective treatment for patients with refractory epilepsy caused by PGMH.

参考文献/References:

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备注/Memo

备注/Memo:
（2023-04-30收稿，2023-06-02修回）
通讯作者：宋　健，E-mail：songjian0505@smu.edu.cn
更新日期/Last Update: 2022-07-31