[1]张文华　谢　蒙　王　旋　林敏华.内镜手术与显微手术治疗垂体瘤疗效的Meta分析[J].中国临床神经外科杂志,2015,(02):78-80.[doi:10.13798/j.issn.1009-153X.2015.02.004]
　ZHANG Wen-hua,XIE Meng,WANG Xuan,et al.Endoscopic surgery and microsurgery for pituitary adenomas: a Meta analysis[J].,2015,(02):78-80.[doi:10.13798/j.issn.1009-153X.2015.02.004]
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内镜手术与显微手术治疗垂体瘤疗效的Meta分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年02期
页码:
78-80
栏目:
论著
出版日期:
2015-02-28

文章信息/Info

Title:
Endoscopic surgery and microsurgery for pituitary adenomas: a Meta analysis
文章编号:
1009-153X（2015）02-0078-03
作者:
张文华　谢　蒙　王　旋　林敏华
430022 武汉，华中科技大学同济医学院附属协和医院神经外科（张文华、王　旋、林敏华）；430071 武汉，武汉大学中南医院儿科（谢　蒙）
通讯作者：林敏华，E-mail：LMH62265681@163.com
Author(s):
ZHANG Wen-hua1;  XIE Meng2;  WANG Xuan1;  LIN Min-hua1.
1. Department of Neurosurgery, Union Hospital, Tongji Medical School, Huazhong University of Sciences and Technology, Wuhan 430022, China;
2. Department of Paediatrics, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
关键词:
垂体腺瘤; 神经内镜手术; 显微手术; 疗效; Meta分析
Keywords:
Pituitary adenoma;  Endoscopic surgery;  Microsurgery;  Curative effect;  Safety;  Meta analysis
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2015.02.004
文献标志码:
A
摘要:
目的 比较内镜手术与显微手术治疗垂体腺瘤的安全性和有效性。方法 计算机检索Pubmed、EMbase、CBM、CNKI、万方及VIP等数据库，查找所有比较内镜手术与显微手术治疗垂体瘤的随机对照试验或病例对照研究，检索时限均为建库至2014年5月31日。按纳入排除标准由两人独立进行研究的筛选、资料提取和质量评价后，采用RevMan5.2软件进行Meta分析。结果 共纳入8个研究、712例患者，结果显示，与显微手术相比，内镜手术肿瘤全切率[优势比（OR）=1.23；95%可信区间（CI）（0.62~2.46）；P=0.56]、手术时间（P>0.05）、术后激素水平改善率[OR=1.21；95%CI(0.58~2.55)；P=0.61]、术后脑脊液漏发生率[OR=1.44；95%CI（0.80~2.58）；P=0.23]、脑/脑膜炎发生率明显减少[OR=1.15；95%CI（0.38~3.48）；P=0.81]、尿崩发生率[OR=1.17；95%CI（0.71~1.94）；P=0.53]均无明显改善，而术后鼻出血发生率[OR=0.24；95%CI（0.07~0.78）；P=0.02]和术后住院天数明显缩短（P<0.05）。>结论 内镜手术与显微手术相比其术后鼻出血患者较少，术后住院天数短。
Abstract:
Objective To compare the safety of endoscopic surgery and its effect on pituitary adenomas with microsurgery. Methods The databases including Pubmed, EMbase, CBM, CNKI, VIP and Wanfang were searched by the computer from the time of the databases establishment to May 31, 2014 for collecting the randomized control trials and case control studies about the endoscopic surgery vs microsurgery for the pituitary adenomas. Meta analyses of the data derived from the databases which had been selected and assessed respectively by two reviewers were performed by the RevMan 5.2 software. Results Eight studies involving 712 patients were included in the present study. The comprehensive Results showed by Meta analysis were as follows. There were significant differences in the occurrent rate of epistaxis [OR=0.24, 95% CI (0.07~0.78), P=0.02] and postoperative hospital stay (PP>0.05). Conclusions The endoscopic surgery may reduce the occurrent rate of the epistaxis and shorten hospital stay compared to the microsurgery in the patients with pituitary adenomas.

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更新日期/Last Update: 2015-02-28