[1]江敦清　宋熙文　陈世文.IL-6和VEGF在慢性硬膜下血肿中的检测及意义[J].中国临床神经外科杂志,2015,(05):287-289.[doi:10.13798/j.issn.1009-153X.2015.05.010]
　JIANG Dun-qing,SONG Xi-wen,CHEN Shi-wen..Detection of IL-6 and VEGF levels in chronic subdural hematomas and their meanings[J].,2015,(05):287-289.[doi:10.13798/j.issn.1009-153X.2015.05.010]
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IL-6和VEGF在慢性硬膜下血肿中的检测及意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年05期
页码:
287-289
栏目:
论著
出版日期:
2015-05-30

文章信息/Info

Title:
Detection of IL-6 and VEGF levels in chronic subdural hematomas and their meanings
文章编号:
1009-153X（2015）05-0287-03
作者:
江敦清　宋熙文　陈世文
201411 上海，上海交通大学附属第九人民医院奉城分院神经外科（江敦清，宋熙文）；200233 上海，上海交通大学附属第六人民医院神经外科（陈世文）
Author(s):
JIANG Dun-qing1;  SONG Xi-wen1;  CHEN Shi-wen2.
1. Department of Neurosurgery, Fengcheng Branch, Affiliated Ninth People's Hospital, Shanghai Jiaotong University, Shanghai 201411, China; 2. Department of Neurosurgery, Affiliated Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, Ch
关键词:
慢性硬膜下血肿; 白介素-6; 血管内皮生长因子; 病理发生
Keywords:
Chronic subdural hematoma;  Interleukin-6;  Vascular endothelial growth factor;  Pathogenesis
分类号:
R 739.41; R 73-35+4
DOI:
10.13798/j.issn.1009-153X.2015.05.010
文献标志码:
A
摘要:
目的 探讨慢性硬膜下血肿（CSDH）患者白介素-6（IL-6）和血管内皮生长因子（VEGF）表达及意义。方法 选取CSDH患者20例，均行钻孔引流术治疗，术中在骨孔内全层切取硬膜和血肿外膜，采用HE染色和免疫组化染色检查VEGF表达。选取同期健康体检者10 例作为对照。采集CSDH患者血肿液和外周血以及对照组外周血，应用酶联免疫吸附法检测IL-6和VEGF浓度。结果 CSDH患者血肿外膜可见嗜酸性粒细胞、毛细血管增生及大量红细胞渗出；血肿外膜VEGF表达呈强阳性。CSDH血肿液和外周血IL-6和VEGF浓度均明显高于对照组（P<0.01），而且，CSDH患者血肿液IL-6和VEGF浓度明显高于其外周血浓度（P<0.01）。结论 CSDH患者血肿腔IL-6与VEGF含量增高，提示IL-6与VEGF可能相互促进，共同参与CSDH的形成。
Abstract:
Objective To explore the role of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in the development of chronic subdural hematomas (CSDH) and its mechanism. Methods The levels of IL-6 and VEGF in outer membrane of CSDH, hematomas fluid and the serum of peripheral venous blood were detected respectively by emzye-labelled immunosorbent assay and immunohestochemical technique in 20 patients with CSDH including 18 males and 2 females, who received the operation of burr hole and drainage (observed group) and the serum levels of IL-6 and VEGF in 10 healthy volunteers including 9 males and 1 female, who served as control group. Results ①There were a number of Eosinophile granulocytes and red blood cells in CSDH and the many capillaries proliferated in the outer membrane of CSDH. The high expression of VEGF was observed in the outer membrance of CSDH. ② There were insignificant difference in the serum levels of VEGF and IL-6 between both the groups (P>0.05). The levels of VEGF and IL-6 were significantly higher in CSDH fluid than those in the serum of the control group (P<0.01). Conclusions They are suggested that IL-6 may take part in the local inflammatory response of CSDH, VEGF may be an important factor in the formation of new vessels growth and IL-6 and VEGF may play an important role in the development of CSDH.

参考文献/References:

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更新日期/Last Update: 2015-05-30