[1]吴 鹏 王跃飞 邵灵敏 陈谦学.神经节苷脂对颅脑损伤后认知功能障碍疗效的系统评价[J].中国临床神经外科杂志,2015,(07):395-397.[doi:10.13798/j.issn.1009-153X.2015.07.004]
 WU Peng,WANG Yue-feng,SHAO Ling-min,et al.Meta analysis of curative effect of ganglioside on cognitive dysfunction in the patients with traumatic brain injury[J].,2015,(07):395-397.[doi:10.13798/j.issn.1009-153X.2015.07.004]
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年07期
页码:
395-397
栏目:
论著
出版日期:
2015-07-30

文章信息/Info

Title:
Meta analysis of curative effect of ganglioside on cognitive dysfunction in the patients with traumatic brain injury
文章编号:
1009-153X(2015)07-0395-03
作者:
吴 鹏 王跃飞 邵灵敏 陈谦学
430060 武汉,武汉大学人民医院神经外科(吴 鹏、王跃飞、邵灵敏、陈谦学)
通讯作者:陈谦学,E-mail:chenqx666@sohu.com
Author(s):
WU Peng WANG Yue-feng SHAO Ling-min CHEN Qian-xue.
Department of Neurosurgery, Renmin Hospital, Wuhan University, Wuhan 430060, China
关键词:
颅脑损伤认知功能障碍神经节苷脂系统评价
Keywords:
Traumatic brain injury Cognitive dysfunction Gangliosides Meta analysis
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2015.07.004
文献标志码:
A
摘要:
目的 评价神经节苷脂在颅脑损伤后认知功能障碍中的疗效。方法 计算机检索PubMed、EMbase、CENTRAL、中国知网、维普数据库和万方数据库中近十年所有发表的神经节苷脂治疗颅脑损伤后认知功能障碍的临床随机对照试验,纳入符合标准的文献并提取数据,采用RevMan 5.1软件进行Meta分析,并用GRADEpro软件进行证据质量评价。结果 共纳入5个研究,347例患者,Meta分析结果显示神经节苷脂组患者治疗后1周[WMD=4.72,95%CI(3.22,6.21),P<0.01]和治疗后3~4周[wmd>P<0.001]mmse评分均显著高于常规治疗组患者。>结论 神经节苷脂能改善患者颅脑损伤后患者的认知功能。
Abstract:
Objective To evaluate the curative effect of gangliosides on cognitive dysfunction in the patients with traumatic brain injury (TBI). Methods The databases of PubMed, EMbase, CENTRAL, CNKI, VIP and Wanfang were searched for the randomized clinical trials published in recent ten years, which studied the curative effect of gangliosides on cognitive dysfunction in the patients with TBI. Meta analysis of these data were performed by RevMan 5.1 and their quality was evaluated by GRADEpro. Results Five studies about the curative effect of ganglionsides on cognitive dysfunction in 347 patients with TBI were screened. Meta analysis showed that mini-mental state examination (MMSE) score was significantly higher in the patients treated by ganglionside than that in the patients treated by conventional method 1 week [WMD=4.72, 95% CI (3.22, 6.21), P<0.01] and="" 3="" or="" 4="" weeks="" [wmd="5.59," 95%="" ci="" (4.39,="" 6.79),="">P

参考文献/References:

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更新日期/Last Update: 2015-07-30