[1]陈 奎 孙兆良 综述 冯东福 审校.mTOR与中枢神经系统轴索再生[J].中国临床神经外科杂志,2015,(08):506-508.[doi:10.13798/j.issn.1009-153X.2015.08.024]
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mTOR与中枢神经系统轴索再生()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年08期
页码:
506-508
栏目:
论著
出版日期:
2015-08-25

文章信息/Info

文章编号:
1009-153X(2015)08-0506-03
作者:
陈 奎 孙兆良 综述 冯东福 审校
201999 上海,上海交通大学医学院附属第三人民医院神经外科(陈 奎、孙兆良、冯东福)
关键词:
中枢神经系统轴索再生哺乳动物雷帕霉素靶蛋白信号通路
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2015.08.024
文献标志码:
B

参考文献/References:

[1] Yang P, Yang Z. Enhancing intrinsic growth capacity pro- motes adult CNS regeneration [J]. J Neurol Sci, 2012, 312(1-2): 1-6.
[2] Pene F, Claessens YE, Muller O, et al. Role of the phospha- tidylinositol 3-kinase/Akt and mTOR/P70S6-kinase path- ways in the proliferation and apoptosis in multiple myeloma [J]. Oncogene, 2002, 21(43): 6587-6597.
[3] Leibinger M, Andreadaki A, Fischer D. Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation [J]. Neurobiol Dis, 2012, 46(2): 314-324.
[4] 胡 笑,程黎明. 雷帕霉素靶蛋白在中枢神经损伤修复 中的作用研究进展 [J]. 中华实验外科杂志,2012,29(7): 1412-1413.
[5] Swiech L, Perycz M, Malik A, et al. Role of mTOR in phy- siology and pathology of the nervous system [J]. BBA Prot proteam, 2008, 1784(1): 116-132.
[6] Avruch J, Long X, Lin Y, et al. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor [J]. Biochem Soc Trans, 2009, 37(Pt 1): 223-226.
[7] Xu M F, Zhou H, Hu C Y, et al. The mechanisms of EGFR in the regulation of axon regeneration [J]. Cell Biochem Funct, 2014, 32(1): 101-105.
[8] Park K K, Liu K, Hu Y, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway [J]. Science, 2008, 322(5903): 963-966.
[9] Xu J T, Zhao X, Yaster M, et al. Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn [J]. Brain Res, 2010, 1336: 46-57.
[10] Chen S, Atkins CM, Liu CL, et al. Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury [J]. J Cereb Blood Flow Metab, 2007, 27(5): 939-949.
[11] Verma P, Chierzi S, Codd AM, et al. Axonal protein syn- thesis and degradation are necessary for efficient growth cone regeneration [J]. J Neurosci, 2005, 25(2): 331-342.
[12] Leibinger M, Muller A, Gobrecht P, et al. Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation [J]. Cell Death Dis, 2013, 4: e609.
[13] Yang P, Wen H, Ou S, et al. IL-6 promotes regeneration and functional recovery after cortical spinal tract injury by reactivating intrinsic growth program of neurons and enhan- cing synapse formation [J]. Exp Neurol, 2012, 236(1): 19- 27.
[14] Dabritz J, Bonkowski E, Chalk C, et al. Granulocyte macro- phage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease [J]. Am J Gastroenterol, 2013.
[15] Liu G, Detloff MR, Miller KN, et al. Exercise modulates microRNAs that affect the PTEN/mTOR pathway in rats after spinal cord injury [J]. Exp Neurol, 2012, 233(1): 447- 456.
[16] He Z. Intrinsic control of axon regeneration [J]. J Biomed Res, 2010, 24(1): 2-5.
[17] Park KK, Liu K, Hu Y, et al. PTEN/mTOR and axon regene- ration [J]. Exp Neurol, 2010, 223(1): 45-50.
[18] Smith PD, Sun F, Park KK, et al. SOCS3 deletion promotes optic nerve regeneration in vivo [J]. Neuron, 2009, 64(5): 617-623.
[19] Sun F, Park KK, Belin S, et al. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3 [J]. Nature, 2011, 480(7377): 372-375.
[20] Codeluppi S, Svensson CI, Hefferan MP, et al. The Rheb- mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord [J]. J Neurosci, 2009, 29(4): 1093-1104.
[21] Erlich S, Alexandrovich A, Shohami E, et al. Rapamycin is a neuroprotective treatment for traumatic brain injury [J]. Neurobiol Dis, 2007, 26(1): 86-93.
[22] Zhao T, Qi Y, Li Y, et al. PI3 Kinase regulation of neural regeneration and muscle hypertrophy after spinal cord injury [J]. Mol Biol Rep, 2012, 39(4): 3541-3547.
[23] Sun G, Li Z, Wang X, et al. Modulation of MAPK and Akt signaling pathways in proximal segment of injured sciatic nerves [J]. Neurosci Lett, 2013, 534: 205-210.
[24] Ramamurthy S, Chang E, Cao Y, et al. AMPK activation regulates neuronal structure in developing hippocampal neurons [J]. Neuroscience, 2013, 259C: 13-24.
[25] Hu LY, Sun ZG, Wen YM, et al. ATP-mediated protein kinase B Akt/mammalian target of rapamycin mTOR/p70 ribosomal S6 protein p70S6 kinase signaling pathway acti- vation promotes improvement of locomotor function after spinal cord injury in rats [J]. Neuroscience, 2010, 169(3): 1046-1062.

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备注/Memo

备注/Memo:
通讯作者:冯东福,E-mail:feng_df@yahoo.com
更新日期/Last Update: 2016-08-25