[1]闫　进　李　松　杨　辉.1H-MRS对卵泡刺激素免疫阳性垂体腺瘤的诊断和预后评估的价值[J].中国临床神经外科杂志,2015,(10):588-590.[doi:10.13798/j.issn.1009-153X.2015.10.004]
　YAN Jin,LI Song,YANG Hui..Value of 1H-MRS to diagnosis and assessment of prognoses in patients with non-functioning gonadotroph adenomas[J].,2015,(10):588-590.[doi:10.13798/j.issn.1009-153X.2015.10.004]
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1H-MRS对卵泡刺激素免疫阳性垂体腺瘤的诊断和预后评估的价值()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2015年10期
页码:
588-590
栏目:
论著
出版日期:
2015-10-30

文章信息/Info

Title:
Value of 1H-MRS to diagnosis and assessment of prognoses in patients with non-functioning gonadotroph adenomas
文章编号:
1009-153X（2015）10-0588-03
作者:
闫　进　李　松　杨　辉
400037 重庆，第三军医大学新桥医院神经外科
通讯作者：杨　辉，E-mail:13808390069@163.com
Author(s):
YAN Jin;  LI Song;  YANG Hui.
Department of Neurosurgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
关键词:
垂体腺瘤; 卵泡刺激素; 免疫阳性; 1H-磁共振波谱; 诊断; 复发; 预后评估
Keywords:
1H-MRS;  Non-functioning gonadotroph adenomas;  Diagnosis;  Recurrence
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2015.10.004
文献标志码:
A
摘要:
目的 探讨1H-磁共振波谱（1H-MRS）对卵泡刺激素（FSH）免疫阳性垂体腺瘤的诊断和预后评估的价值。方法 收集自2007年1月至2015年1月经病理确诊的28例FSH免疫阳性垂体腺瘤患者的临床资料，术后6例复发；Knosp分级3~4级15例，1~2级13例；所有患者术前均行1H-MRS检查，分析胆碱（Ch）/肌酐（Cr）、Ch/N-乙酰天门冬氨酸（NAA）、NAA/Cr等比值。结果 28例病变区Ch/NAA比值增高比例（75.0%）较丘脑外侧皮质区明显增高（7.1%；P<0.05）；受试者工作特征（ROC）曲线显示，Ch/NAA比值的阈值为1.2595，诊断腺瘤的敏感度为75.0%，特异度为92.9%。15例Knop分级3~4级患者Ch/NAA比值和Ch/Cr比值增高比例（80.0%）较13例Knop分级1~2级患者明显增高（15.4%；P<0.05）；ROC曲线显示，Ch/Cr比值和Ch/NAA比值均有统计学差异（P<0.05），Ch/NAA比值曲线下面积为0.841，结果更为显著；Ch/NAA比值的阈值为2.235，区分腺瘤Knosp分级敏感度为80.0%，特异度为84.6%。6例复发患者Ch/Cr比值增高比例（83.3%）较22例未复发患者明显增高（27.3%；P<0.05）；ROC曲线显示，Ch/Cr比值的阈值为2.2685，评估腺瘤复发敏感性为83.3%，特异性为72.7%。结论 1H-MRS对FSH免疫阳性垂体腺瘤的术前诊断、Knosp分级和预后评估具有参考价值。
Abstract:
Objective To investigate the value of 1H-MRS to diagnosis and assessment of prognoses in patients with non- functioning gonadotroph adenomas (NFGA). Methods The clinical data of 28 patients with NFGA proved by pathological examination in whom FSH was positive, from January, 2007 to January, 2015 were collected. The 1H-MRS imaging data of 28 patients, of whom, 6 had relapse and 22 not, were analyzed retrospectively. The relationship of ratios of Ch/Cr, Ch/NAA and NAA/Cr with diagnosis of NFGA, Knosp grade and prognosis was analyzed. Results The efficiency of 1H-MRS to diagnosis of NFGA: the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate were 75.0%, 92.9%, 91.3%, 78.8% and 83.9% respectively. The ratio of Ch/NAA threshold was 1.2595. The efficiency of 1H-MRS to predicting Knosp grade: the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate were 80.0%, 84.6%, 85.7%, 78.6% and 89.3% respectively. The ratio of Ch/NAA threshold was 2.235. The efficiency of 1H-MRS to predicting NFGA recurrence: the sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate were 83.3%, 72.7%, 45.5%, 94.1% and 75.0% respectively. The ratio of Ch/Cr threshold was 2.2685. Conclusion 1H-MRS may provide valid reference index for the diagnosis, Knosp grade and prognoses in the patients with NFGA.

参考文献/References:

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更新日期/Last Update: 2015-10-30