[1]谢宝树　张　林　王　宇　贾　锋　殷玉华.复发性多发胶质母细胞瘤的预后分析[J].中国临床神经外科杂志,2016,(06):333-335.[doi:10.13798/j.issn.1009-153X.2016.06.005]
　XIE Bao-shu,ZHANG Lin,WANG Yu,et al.Analysis of prognoses in patients with recurrent multiple glioblastomas[J].,2016,(06):333-335.[doi:10.13798/j.issn.1009-153X.2016.06.005]
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复发性多发胶质母细胞瘤的预后分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年06期
页码:
333-335
栏目:
论著
出版日期:
2016-06-25

文章信息/Info

Title:
Analysis of prognoses in patients with recurrent multiple glioblastomas
文章编号:
1009-153X（2016）06-0333-03
作者:
谢宝树　张　林　王　宇　贾　锋　殷玉华
200127 上海，上海交通大学医学院附属仁济医院神经外科（谢宝树、张　林、王　宇、贾　锋、殷玉华）
Author(s):
XIE Bao-shu;  ZHANG Lin;  WANG Yu;  JIA Feng;  YIN Yu-hua.
Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China
关键词:
胶质母细胞瘤;  多发性; 复发; 手术; 预后
Keywords:
Multiple glioblastoma;  Surgical resection;  Survival time
分类号:
R 739.41; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2016.06.005
文献标志码:
A
摘要:
目的 探讨复发性多发胶质母细胞瘤（GBM）预后的影响因素。方法 2005年1月至2012年12月手术切除并获得完整随访的复发性GBM 106例，其中单发78例，多发28例（多发组）；根据患者年龄、性别、肿瘤部位、手术切除程度、术后是否放化疗、术前KPS评分从单发GBM中选取与多发GBM相匹配的病例28例作为对照（单发组）；多发组根据肿瘤切除程度进一步分为全切组和部分切除组。结果 本组复发性多发GBM占26.4%。多发组中位生存期（4.5个月）明显短于单发组（8.5个月；P <0.05）。多发患者中，全切组中位生存期（7.9个月）明显长于部分切除组（3.7个月；P <0.05）。结论 复发性多发GBM预后较单发患者差；肿瘤切除程度越高，患者预后也越好，建议术中在保证重要功能的基础上尽量多切除肿瘤。
Abstract:
Objective To explore the factors related to the prognoses in patients with recurrent multiple glioblastomas. Methods Of 106 patients with recurrent multiple glioblastomas, who underwent surgical resection of the tumors from January, 2005 to December, 2012 in our hospital, and were followed up, 78 suffered from solitary lesion and 28 from multiple lesions. Each patient with multiple tumors was matched with a patient with a solitary glioblastoma on the basis of age, gender, tumorous location, extent of resection, postoperative radiotherapy or chemiotherapy and Karnofsky Performance Scale (KPS) score and then case-control study was performed. The patients’ survival time was analyzed by Kaplan-Meier cure and log-rank tests. Results Long-rank test showed that median overall survival time (8.5 months) was significant longer in the patients with solitary glioblastoma than that (4.5 months) in the patients with multiple glioblastomas (P <0.05). The median overall survival time (7.9 months) was significantly longer in the patients with multiple glioblastomas which were totally resected than that (3.6 months) in the patients with multiple glioblastomas which were partially resected (P <0.05). Conclusions It is suggested the prognosis in the patient with multiple glioblastomas is significantly worse than that in patient with solitary glioblastoma. And the more tumor is resected, the better the prognosis will be in the patients with multiple glioblastomas, in who the tumor should be resected totally as possible on the basis of protecting important cerebral function.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81471855）
通讯作者：殷玉华，E-mail：yinyuhuacn@163.com
更新日期/Last Update: 2016-06-20