[1]王瑶瑶.急性脑梗死合并睡眠呼吸暂停综合征血清IGF-1水平与临床预后相关性分析[J].中国临床神经外科杂志,2016,(10):589-592.[doi:10.13798/j.issn.1009-153X.2016.10.005]
　WANG Yao-yao..Analysis of relationship between serum IGF-1 levels and clinical prognoses in patients with acute cerebral infarction complicated by sleep apnea syndrom[J].,2016,(10):589-592.[doi:10.13798/j.issn.1009-153X.2016.10.005]
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急性脑梗死合并睡眠呼吸暂停综合征血清IGF-1水平与临床预后相关性分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年10期
页码:
589-592
栏目:
论著
出版日期:
2016-10-24

文章信息/Info

Title:
Analysis of relationship between serum IGF-1 levels and clinical prognoses in patients with acute cerebral infarction complicated by sleep apnea syndrom
文章编号:
1009-153X（2016）10-0589-04
作者:
王瑶瑶
430080 武汉，华润武钢总医院干保中心
Author(s):
WANG Yao-yao.
Health Care Center for Cadres, Huarun General Hospital, Wuhan Iron and Steel Company Group, Wuhan 430080, China
关键词:
脑梗死; 睡眠呼吸暂停综合征; 胰岛素样生长因子-1; 相关性
Keywords:
Cerebral infarction;  Obstructive sleep apnes ayndrome;  Insulin-like growth factor-1;  Serum level;  Prognosis
分类号:
R 743.9
DOI:
10.13798/j.issn.1009-153X.2016.10.005
文献标志码:
A
摘要:
目的 探讨急性脑梗死合并阻塞性睡眠呼吸暂停综合征（OSAS）血清胰岛素样生长因子-1（IGF-1）水平与神经功能缺损及预后相关性。方法 2014年9月至2015年6月收治符合标准的急性脑梗死合并OSAS 41例为A组，选择同期收治的单纯急性脑梗死40例为B组、单纯OSAS 43例为C组、健康体检者36例为D组。入组后3、14 d采用ELISA方法检测血清IGF-1水平，采用美国国立卫生院卒中量表（NIHSS）评分评价神经功能缺损程度，90 d行改良Rankin量表（mRS）评分判断预后情况。结果 入组后3、14 d，A组血清IGF-1水平均明显均低于B、C和、D组（P<0.05），B、C组又明显低于D组（P<0.05），B、C组之间无明显差异（P>0.05）。A组入组后3、14 d NIHSS评分及90 d mRS评分均明显高于B组（P<0.05）。随着脑梗死严重程度增加，A、B两组血清IGF-1水平显著降低（P<0.05），但两组变化趋势无明显差异（P>0.05）。A、B两组入组后3、14 d NIHSS评分和90 d mRS评分均与血清IGF-1水平呈明显负相关（P<0.05）。结论 急性脑梗死合并OSAS血清IGF-1水平可用于预测病情轻重及临床预后。
Abstract:
Objective To explore the relationship between serum levels of insulin-like growth factor -1 (IGF-1) and clinical prognoses in the patients with acute cerebral infarction (ACI) associated with obstructive sleep apnea syndrome (OSAS). Methods There were 41 patients with ACI associated with OSAS in group A. There were 40 patients with ACI in group B. There were 43 patients with OSAS in group C. There were 36 healthy subjects in group D. The serum IGF-1 levels were determined by enzyme linked immunosorbent assay 3 and 14 days after the admission to hospital in all the groups. The neurologic defect was determined by National Institutes of Health stroke Scale (NIHSS) immediately and 3 and 14 days after the admission to hospital in groups A and B. The prognoses were assessed by modified Rankin scale (MRS) 90 days after the admission to hospital in groups A and B. Results Three and fourteen days after admission to hospital, the serum IGF-1 levels were significantly lower in group A than those in groups B and C (P<0.05), which were significantly lower than those in group D (P<0.05). There were no significant differences in the serum IGF-1 levels 3 and 14 days after the admission to hospital between groups B and C (P>0.05). NIHSS scores 3 and 14 days after the admission to hospital and MRS scores 90 days after the admission to hospital were significantly higher in group A than those in group B (P<0.05). In group A, the level of IGF-1 were significantly lower in 15 patients with severe ACI than those in 15 patients with moderate ACI (P<0.05), in whom the serum levels of IGF-1 were significantly lower than those in 11 patients with mild ACI (P<0.05). In group B, the serum levels of IGF-1 were significantly lower in 14 patients with severe ACI than those in 16 patients with moderate ACI (P<0.05), in whom the serum levels of IGF-1 were significantly lower than those in 10 patients with mild ACI (P<0.05). NIHSS scores 3 and 14 days after the admission to hospital and MRS scores 90 days after the admission to hospital were significantly negatively correlated with the serum levels of IGF-1 in groups A and B (P<0.05). Conclusion It is suggested that the severity of the conditions and the prognoses may be predicted by the serum IGF-1 levels in the patients with ACI complicated by OSAS.

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更新日期/Last Update: 2016-10-25