[1]任 勇,何 威,齐曼丽,等.TEM8在人脑胶质瘤中的表达及其意义[J].中国临床神经外科杂志,2016,(12):768-770.[doi:10.13798/j.issn.1009-153X.2016.12.012]
 REN Yong,HE Wei,QI Man-li,et al.Expression of TEM8 in human gliomas and its clinical meaning[J].,2016,(12):768-770.[doi:10.13798/j.issn.1009-153X.2016.12.012]
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TEM8在人脑胶质瘤中的表达及其意义()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2016年12期
页码:
768-770
栏目:
论著
出版日期:
2016-12-25

文章信息/Info

Title:
Expression of TEM8 in human gliomas and its clinical meaning
文章编号:
1009-153X(2016)12-0768-03
作者:
任 勇何 威齐曼丽陈昕薇梁励玮冯俊明
430070 武汉,中国人民解放军武汉总医院病理科(任 勇,齐曼丽,陈昕薇,梁励玮,冯俊明),老年二科(何 威)
Author(s):
REN Yong1 HE Wei2 QI Man-li1 CHEN Xin-wei1 LIANG Li-wei1 FENG Jun- ming1
1. Department of Pathology, Wuhan General Hospital, PLA, Wuhan 430070, China; 2. Second Department of Geriatrics, Wuhan General Hospital, PLA, Wuhan 430070, China
关键词:
胶质瘤肿瘤内皮标记物8预后免疫组织化学染色
Keywords:
Glioma TEM8 protein Expression Prognosis Immunohischemistry
分类号:
R 739.41; Q786
DOI:
10.13798/j.issn.1009-153X.2016.12.012
文献标志码:
A
摘要:
目的 探讨肿瘤内皮标记物8(TEM8)在人脑胶质瘤组织中的表达特点及其意义。方法 采用免疫组化法检测84例脑胶质瘤及15例颅脑损伤减压手术切除的正常脑组织标本TEM8的表达,并分析TEM8表达与胶质瘤临床病理特征及预后的关系。结果 胶质瘤TEM8高表达率(47.6%,40/84)明显高于正常脑组织(6.7%,1/15;P<0.01)。高级别胶质瘤TEM8高表达率(64.4%,29/45)显著高于低级别胶质瘤(28.2%,11/39;P<0.01)。TEM8表达与胶质瘤患者性别,年龄,肿瘤部位和大小无关(P>0.05)。TEM8高表达胶质瘤患者中位生存期(24.5个月)明显长于TEM8低表达胶质瘤患者中位生存期(36.0个月;P<0.05)。结论 胶质瘤组织TEM8呈高表达,并且与胶质瘤级别和预后显著相关。
Abstract:
Objective To investigate the expression of tumor endothelial marker 8 (TEM8) protein in human glioma and its clinical meaning. Methods The expression of TEM8 was determined in 84 glioma samples and 15 normal brain tissues samples by immunohistochemistrical technique. The relationship of TEM8 expression in the gliomas with glioma clinicopathological parameters and the patients' survival rates were analyzed. Results The positive expression rate of TEM8 protein was significantly higher in glioma tissues (47.6%, 40/84) than that (6.7%, 1/15) in the normal brain tissues (P<0.01). The positive expression rate (64.4%, 29/45) of TEM8 protein was significantly higher in the grades Ⅲ-Ⅳ gliomas than that (28.2%, 11/39) in grades Ⅰ~Ⅱ gliomas (P<0.05). Kaplan-Meier survival analysis suggested that the positive expression of TEM8 protein was negatively correlated with the overall survival rate in the patients with gliomas (P<0.05). Conclusions It is suggested that high level of TEM8 protein expression is significantly correlated with glioma progression and the patient's poor prognosis, so it can be used as a novel glioma biomarker and a new target for treating glioma.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:湖北省自然科学基金(2015CFB280);广州军区武汉总医院课题(YZ201503) 作者单位:430070 武汉,中国人民解放军武汉总医院病理科(任 勇,齐曼丽,陈昕薇,梁励玮,冯俊明),老年二科(何 威) 通讯作者:冯俊明,E-mail:rybest@126.com
更新日期/Last Update: 1900-01-01