[1]李建明.三维适形放疗联合替莫唑胺化疗对恶性脑胶质瘤术后残留的疗效分析[J].中国临床神经外科杂志,2017,(05):316.[doi:10.13798/j.issn.1009-153X.2017.05.011]
　LI Jian-ming..Short-term curative effect and factors related to prognosis of three dimensional conformal radiotherapy combined with temozolomide chemotherapy on residual malignant gliomas after surgery[J].,2017,(05):316.[doi:10.13798/j.issn.1009-153X.2017.05.011]
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三维适形放疗联合替莫唑胺化疗对恶性脑胶质瘤术后残留的疗效分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年05期
页码:
316
栏目:
论著
出版日期:
2017-05-20

文章信息/Info

Title:
Short-term curative effect and factors related to prognosis of three dimensional conformal radiotherapy combined with temozolomide chemotherapy on residual malignant gliomas after surgery
文章编号:
1009-153X（2017）05-0316-02
作者:
李建明
643020 四川，自贡市第三人民医院神经外科
Author(s):
LI Jian-ming.
Department of Neurosurgery, Zigong Municipal Third People’s Hospital, Zigong 643020, China
关键词:
恶性脑胶质瘤; 术后残留; 三维适形放疗; 替莫唑胺; 疗效
Keywords:
Malignant gliomas;  Residues;  Prognosis;  Three dimensional conformal radiotherapy;  Temozolomide;  Chemotherapy
分类号:
R 739.41
DOI:
10.13798/j.issn.1009-153X.2017.05.011
文献标志码:
A
摘要:
目的 探讨三维适形放疗联合替莫唑胺化疗对恶性脑胶质瘤术后残留的疗效。方法 2012年11月至2015年4月收治恶性脑胶质瘤术后残留58例，根据治疗方法分为观察组和对照组，各29例。对照组单纯采用三维适形放疗，观察组采用三维适形放疗联合替莫唑胺化疗，连续治疗4~6个周期。结果 观察组总有效率（68.97%）、疾病控制率（86.21%）均明显高于对照组（分别为41.38%、62.07%；P<0.05）。观察组1年生存率（72.41%）明显高于对照组（44.83%；P<0.05）。年龄>60岁、病理分级、术前KPS评分、是否完成化疗周期均是影响恶性脑胶质瘤术后残留预后的因素（P<0.05）。结论 三维适形放疗联合替莫唑胺化疗治疗恶性脑胶质瘤术后残留的近期疗效显著，可提高1年生存率。
Abstract:
Objective To investigate the short-term curative effect of three dimensional conformal radiotherapy (3D-CRT) combined with temozolomide chemotherapy on the residual malignant gliomas after surgery and the factors related to the prognosis. Methods Fifty-eight patients with residues of malignant gliomas after the surgery were divided into the observed group, in which 29 patients were treated by 3D-CRT combined with temozolomide chemotherapy and the control group, in which 29 patients were treated only by 3D-CRT from November, 2012 to April, 2015 in Zigong Municipal Third People’s Hospital. All the patients were followed up 1 year after the treatment lasting from 4 to 6 cycles. The curative effects and factors related to the prognoses were analyzed in both the groups. Results The total effective rate (68.97%, 20/29) and disease control rate (86.21%, 25/29) were significantly higher in the observed group than those [41.38% (12/29) and 62.07% (18/29), respectively] in the control group (P<0.05). The survival rate (72.41%, 21/29) was significantly higher in the observed group than that (44.83%, 13/29) in the control group 1 year after the treatment(P<0.05). The factors related to prognosis included age over 60 years, who pathological grade, preoperative Karnofsky performance score (KPS) and the completion of chemotherapy cycle in the patients with residual malignant gliomas after the surgery (P<0.05). Conclusions The prognoses can be significantly improved by 3D-CRT combined with temozolomide chemotherapy in the patients with residual malignant gliomas after the surgery, in whom the age over 60 years, pathological grade, preoperative KPS, completion of the chemotherapy cycle were factors affecting the prognosis of patients.

参考文献/References:

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更新日期/Last Update: 2017-05-20