[1]高玉松,吕宏迪,扈俊华,等.颅脑爆震伤病人恢复期脑网络的研究[J].中国临床神经外科杂志,2017,(07):477-479.[doi:10.13798/j.issn.1009-153X.2017.07.010]
　GAO Yu-song,Lü Hong-di,HU Jun-hua,et al.Change in brain network in patients with craniocerebral blast injury: a study based on resting functional magnetic resonance imaging[J].,2017,(07):477-479.[doi:10.13798/j.issn.1009-153X.2017.07.010]
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颅脑爆震伤病人恢复期脑网络的研究()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2017年07期
页码:
477-479
栏目:
论著
出版日期:
2017-07-20

文章信息/Info

Title:
Change in brain network in patients with craniocerebral blast injury: a study based on resting functional magnetic resonance imaging
文章编号:
1009-153X（2017）07-0477-03
作者:
高玉松; 吕宏迪; 扈俊华; 罗新民; 胡承啸; 张松坡; 柴超; 雷亚平
450000 河南驻马店，中国人民解放军第159医院神经外科（高玉松、扈俊华、罗新民、胡承啸、张松坡、柴　超、雷亚平）；450000 河南驻马店，中国人民解放军第159医院（吕宏迪）
通讯作者：吕宏迪，E-mail：rancho1213@foxmail.com
Author(s):
GAO Yu-song1;  Lü Hong-di2;  HU Jun-hua1;  LUO Xin-min1;  HU Cheng-xiao1;  HU Song-po1;  CHAI Chao1;  LEI Ya-ping1.
1. Department of Neurosurgery, The 159th Hospital, PLA, Zhumadian 463000, China;
2. The 159th Hospital, PLA, Zhumadian 463000, China
关键词:
颅脑爆震伤; 功能磁共振; 大脑功能网络; 小世界
Keywords:
Craniocerebral blast injury;  Resting fMRI;  Brain functional network;  Small world
分类号:
R 651.1+5
DOI:
10.13798/j.issn.1009-153X.2017.07.010
文献标志码:
A
摘要:
目的 利用静息态功能磁共振构建脑网络，分析颅脑爆震伤病人慢性期脑网络的特点。方法 搜集颅脑爆震伤病人5例，健康对照10例，采集静息态功能磁共振数据，预处理后用AAL90模板标记脑区，计算脑区间相关系数，构建90×90的矩阵，评估其小世界性，并计算其网络参数。结果 颅脑爆震伤病人和正常受试者的脑网络均存在小世界性，颅脑爆震伤病人的局部效率和度显著降低（P<0.05），而全局效率无统计学差异（P>0.05）。结论 颅脑爆震伤病人的脑网络依然有小世界性，但网络的局部效率和平均连接度均降低，可能预示着脑功能的潜在障碍。
Abstract:
Objective To analyze the properties of brain network by resting functional magnetic resonance imaging (fMRI) in patients with craniocerebral blast injury. Methods The resting fMRI was performed in 5 patients with craniocerebral blast injury and 10 healthy subjects serving as control. The brain areas were labeled by anatomical automatic labeling 90 after the pretreatment. The coefficients of correlation of the brain regions were calculated and 90×90 matrix was constructed. Its small world was assessed and the areas under curve of network parameter were calculated. Results The characteristics of the small world of brain network in the patients with craniocerebral blast injury were in line with those in the healthy subjects, and the local efficiency and average connectivity degree were significantly lower in the patients with craniocerebral blast injury than those in the healthy subjects (P<0.05). Conclusions The brain network still had the characteristics of the small world in the patients with craniocerebral blast injury, in whom the significantly lower local efficiency and the average connectivity degree than those in the healthy subjects may suggest that there is potential disturbance of cerebral function in the patients with craniocerebral blast injury.

参考文献/References:

[1] Harvey S, Levin and Claudia S. Robertson. Mild traumatic brain injury in translation [J]. Neurotrauma, 2013, 30: 610- 617.
[2] 王正国. 颅脑冲击伤[J]. 中华创伤杂志，2014，30（6）：481- 483.
[3] Thompson JM, Scott KC, Dubinsky L. Battlefield brain: unexplained symptoms and blast-related mild traumatic brain injury [J]. Can Fam Physician, 2008, 54: 1549-1551.
[4] Alexander MP. Mild traumatic brain injury: pathophysiology, natural history, and clinical management [J]. Neurology, 1995, 45: 1253-1260.
[5] Pandit AS, Expert P, Lambiotte R, et al. Traumatic brain injury impairs small-world topology [J]. Neurology, 2013, 80: 1826-1833.
[6] O’Reilly JX1, Croxson PL, Jbabdi S, et al. Causal effect of disconnection lesions on interhemispheric functional con- nectivity in rhesus monkeys [J]. Proc Natl Acad Sci USA, 2013, 110: 13982-13987.
[7] Cao C, Slobounov S. Alteration of cortical functional con- nectivity as a result of traumatic brain injury revealed by graph theory, ICA, and sLORETA analyses of EEG signals [J]. IEEE Trans Neural Syst Rehabil Eng, 2010, 18(1): 11- 19.

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备注/Memo

备注/Memo:
基金项目：军队后勤科研计划项目（CJN15J089）
更新日期/Last Update: 2017-07-25