[1]王谋龙　李爱红　曲良锁.血清ANP水平及ANP基因多态性与缺血性脑卒中相关性的Meta分析[J].中国临床神经外科杂志,2018,(03):161-164.[doi:10.13798/j.issn.1009-153X.2018.03.007]
　WANG Mou-long,LI Ai-hong,QU Liang-suo.Meta-analysis of relativity of ANP serum levels and genetic polymorphisms with ischemic stroke risk[J].,2018,(03):161-164.[doi:10.13798/j.issn.1009-153X.2018.03.007]
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血清ANP水平及ANP基因多态性与缺血性脑卒中相关性的Meta分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年03期
页码:
161-164
栏目:
论著
出版日期:
2018-04-01

文章信息/Info

Title:
Meta-analysis of relativity of ANP serum levels and genetic polymorphisms with ischemic stroke risk
文章编号:
1009-153X（2018）03-0161-04
作者:
王谋龙　李爱红　曲良锁
作者单位：255120 山东淄博，山东能源淄博矿业集团中心医院神经外科（王谋龙、李爱红、曲良锁）
Author(s):
WANG Mou-long;  LI Ai-hong;  QU Liang-suo
Department of Neurosurgery, Central Hospital, Shandong Energy Zibo Mining Group Co. Ltd, Zibo 255120, China
关键词:
缺血性脑卒中; 心房钠尿肽; 基因多态性; 血清水平; Meta分析; 相关性
Keywords:
Atrial natriuretic peptide;  Ischemic stroke;  Genetic polymorphism;  Serum;  Meta-analysis
分类号:
R 743
DOI:
10.13798/j.issn.1009-153X.2018.03.007
文献标志码:
A
摘要:
目的 探讨血清心房钠尿肽（ANP）水平及ANP基因多态性与缺血性脑卒中（IS）发作风险的关系。方法 计算机检索PubMed、CISCOM、CINAHL、Web of Science、EBSCO、Cochrane Library等英文数据库，以及中国期刊全文数据库、中国生物医学文献数据库、维普中文期刊数据库和万方数据库等中文数据库，纳入2014年之前有关血清ANP水平和ANP基因多态性与IS相关性的病例对照研究，对符合条件的数据用Stata 12.0软件进行Meta分析。结果 纳入12项研究，包括1 285例IS和1 088例健康对照。ANP 2238T/C多态性可能增加IS的风险（C与T比较：OR=2.26；95% CI 1.59~3.23；P<0.01；TC+CC与TT比较：OR=2.26；95% CI 1.34~3.81；P=0.002）。ANP 1837 G/A和664 G/A的多态性与IS的发生无相关性。IS血清ANP水平显著高于健康对照组（SMD=3.12；95% CI 1.16~5.07；P=0.002）。结论 血清ANP水平和ANP基因多态性与IS的发生有相关性，血清ANP水平和ANP基因多态性可能是IS发生的危险因素。
Abstract:
Objective To evaluate the relativity of the serum level and genetic polymorphism of atrial natriuretic peptide (ANP) with the risk of ischemic stroke (IS). Methods The databases including PubMed, CISCOM, CINAHL, Web of Science, EBSCO, Cochrane Library, CBM, VIP and Wanfang were searched for the original articles of random-control study of the relationship of the serum levels and genetic polymorphism of ANP with the risk of IS and published before 2014. A meta-analysis was performed with Stata 12.0 software. Results Twelve original articles about clinical study of the relationship of the serum levels and genetic polymorphism of ANP with the risk of IS including 1,285 patients with IS and 1,088 healthy subjects serving as control were acquired from the above-mentioned databases. Meta-analysis showed that ANP 2238 T/C polymorphism might increase the risk of IS (C allele vs. T allele: OR=2.26, 95% CI: 1.59~3.23, P<0.01; TC+CC vs. TT: OR=2.26, 95% CI: 1.34~3.81, P=0.002; respectively) and ANP 1837 G/A and 664 G/A polymorphisms were insignificantly related to IS risk. The level of serum ANP was significantly higher in the patients with IS than that in the healthy subjects (SMD=3.12, 95% CI: 1.16~5.07, P=0.002). Conclusion It is suggested that the serum levels and genetic polymorphism of ANP was associated with IS.

参考文献/References:

[1] Ling X, Zheng Y, Tao J, et al. Association study of polymor- phisms in the ABO gene with ischemic stroke in the popu- lation [J]. BMC Neurol, 2016, 16(1): 146.
[2] Ventura NM, Jin AY, Tse MY, et al. Maternal hypertension programs increased cerebral tissue damage following stroke in adult offspring [J]. Mol Cell Biochem, 2015, 408(1-2): 223-233.
[3] Ventura NM, Peterson NT, Tse MY, et al. Molecular adapta- tions in vasoactive systems during acute stroke in salt- induced hypertension [J]. Mol Cell Biochem, 2015, 399 (1-2): 39-47.
[4] Gupta T, Yang W, Iovannisci DM, et al. Considering the vascular hypothesis for the pathogenesis of small intestinal atresia: a case control study of genetic factors [J]. Am J Med Genet A, 2013, 161A(4): 702-710.
[5] Smith P, Tuomisto MT, Blumenthal J, et al. Psychosocial correlates of atrial natriuretic peptide: a marker of vascular health [J]. Ann Behav Med, 2013, 45(1): 99-109.
[6] Choi J, Jun JH, Lee JA, et al. Yoga for health care in Korea: a protocol for systematic review of clinical trials [J]. J Acupunct Meridian Stud, 2016, 9(4): 213-219.
[7] Estrada V, Tellez MJ, Moya J, et al. High plasma levels of endothelin-1 and atrial natriuretic peptide in patients with acute ischemic stroke [J]. Am J Hypertens, 1994, 7(12): 1085-1089.
[8] 罗玉敏，黄　洁，张德英. 脑梗死患者血浆内皮素和心钠 素含量变化[J]. 中国危重病急救医学，1998，10（11）： 684-685.
[9] Hassan A, Ali N, Dong Y, et al. Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cere- brovascular disease [J]. Neurology, 2001, 57(9): 1726-1728.
[10] 赵　勇，马丽媛，刘力生. ANP基因G664A多态性与出血 性脑卒中的关系[J]. 高血压杂志，2001，9（3）：47-48.
[11] Rubattu S, Stanzione R, Di Angelantonio E, et al. Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans [J]. Stroke, 2004, 35(4): 814-818.
[12] 闵连秋，马维艳，杨　丽，等. 内皮素-1和心钠素在脑梗 死中的作用研究[J]. 中西医结合心脑血管病杂志，2004， 2（2）：86-88.
[13] 刘举珍，李润今. 血浆心房钠尿肽的变化与急性脑卒中的 关系[J]. 神经损伤与功能重建，2006，1（4）：217-218.
[14] 谢向东，胡爱平，姬松波，等. 脑梗死患者血浆TXA2、 PGI2和ANP含量的测定[J]. 中国实用神经疾病杂志， 2006，9（5）：88-89.
[15] 张永利，杨期东，唐震宇，等. 心钠素基因G1837A多态性 与出血性脑卒中的关系[J]. 卒中与神经疾病，2007，14 （2）：76-78.
[16] 张永利，杨期东，申向民，等. 心房利尿钠肽基因T2238C 多态性与缺血性脑卒中的关系[J]. 实用医学杂志，2007， 23（1）：17-18.
[17] 李　锐，孙庆荣，排立平，等. ACI患者治疗前后血浆 ET-1与血清ANF、BNP和TXB2检测的临床意义[J]. 放 射免疫学杂志，2010，23（3）：280-282.
[18] 苑　杰，王　静. 急性脑梗死患者血脑钠素N端前体肽的 水平及意义[J]. 山东医药，2011，51（36）：64-65.
[19] Song W, Wang H, Wu Q. Atrial natriuretic peptide in car- diovascular biology and disease (NPPA) [J]. Gene, 2015, 569(1): 1-6.
[20] Rubattu S, Sciarretta S, Volpe M. Atrial natriuretic peptide gene variants and circulating levels: implications in cardio- vascular diseases [J]. Clin Sci (Lond), 2014, 127(1): 1-13.
[21] Kerkel R, Ulvila J, Magga J. Natriuretic peptides in the regulation of cardiovascular physiology and metabolic events [J]. J Am Heart Assoc, 2015, 4(10): e002423.
[22] Katan M, Moon YP, Paik MC, et al. Procalcitonin and midregional proatrial natriuretic peptide as markers of ischemic stroke: the northern manhattan study [J]. Stroke, 2016, 47(7): 1714-1719.

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更新日期/Last Update: 2018-05-05