[1]贾延增　杨朋范　林　巧　裴家生　陈其钻　钟忠辉.选择性杏仁核-海马切除术对内侧颞叶癫痫病人神经心理学的影响[J].中国临床神经外科杂志,2018,(11):711-713.[doi:10.13798/j.issn.1009-153X.2017.11.003]
　JIA Yan-zeng,YANG Peng-fan,LIN Qiao,et al.Effects of selective amygdalohippocampectomy on neuropsychological outcomes in patients with mesial temporal lobe epilepsy[J].,2018,(11):711-713.[doi:10.13798/j.issn.1009-153X.2017.11.003]
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选择性杏仁核-海马切除术对内侧颞叶癫痫病人神经心理学的影响()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2018年11期
页码:
711-713
栏目:
论著
出版日期:
2018-11-25

文章信息/Info

Title:
Effects of selective amygdalohippocampectomy on neuropsychological outcomes in patients with mesial temporal lobe epilepsy
作者:
贾延增　杨朋范　林　巧　裴家生　陈其钻　钟忠辉
350025 福州，福建医科大学福总临床医学院（福州总医院）神经外科癫痫中心（贾延增、杨朋范、林　巧、裴家生、陈其钻、钟忠辉）
Author(s):
JIA Yan-zeng;  YANG Peng-fan;  LIN Qiao;  PEI Jia-sheng;  CHEN Qi-zuan;  ZHONG Zhong-hui.
Epilepsy Center, Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025, China
关键词:
内侧颞叶癫痫; 海马硬化; 选择性杏仁核-海马切除术; 认知功能
Keywords:
Mesial temporal lobe epilepsy;  Hippocampal sclerosis;  Selective amygdalohippocampectomy;  Neuropsychological outcomes
分类号:
R 742.1; R 651.1+1
DOI:
10.13798/j.issn.1009-153X.2017.11.003
文献标志码:
A
摘要:
目的 探讨选择性杏仁核-海马切除术（SAH）对内侧颞叶癫痫病人认知功能的影响。方法 回顾性分析2009年1月~2017年5月接受SAH治疗的67例内侧颞叶癫痫的临床资料，术前、术后3个月和术后1年均行详细的神经心理学评估，包括智商、记忆商和语言功能。结果 36例行左侧SAH，31例行右侧SAH。术后1年，癫痫控制效果达到Engel分级Ⅰ级50例，Ⅱ级7例，Ⅲ级8例，Ⅳ级2例。术后3个月，左侧手术病人言语功能、记忆商较术前明显降低（P<0.05），右侧手术病人言语理解指数、语义流畅性测验明显改善（P<0.05）；术后1年，无论是左侧手术病人，还是右侧手术病人，智商、记忆商、言语功能较术后3个月略改善（P>0.05）；手术前后视觉记忆均无明显变化（P>0.05）。结论 海马硬化性内侧颞叶癫痫行SAH后，左侧手术病人会出现比较明显的言语和记忆功能减低。
Abstract:
Objective To assess the effects of selective amygdalohippocampectomy (SAH) on neuropsychological outcomes in the patients with mesial temporal lobe epilepsy (MTLE). Methods Sixty-seven patients with MTLE underwent SAH in Fuzhou General Hospital from January, 2009 to May, 2017. All the patients received detailed neuropsychological tests including the intelligence quotient (IQ) test, memory quotient (MQ) test, and language function test before the surgery, and 3 months and 1 year after the surgery. Results Thirty-six (56.7%) patients underwent left SAH and 31(43.3%) underwent right SAH. The following-up 1 year after the surgery showed that, according to Engel classification, the outcomes of epileptic control were Engel class Ⅰ in 50 (74.6%) patients, class Ⅱ in 7 (10.4%), class Ⅲ in 8 (11.9%) and class Ⅳ in 2 (3.0%). The scores of verbal IQ and MQ were significantly lower after the surgery than those before the surgery in the patients undergoing left SAH (P<0.05). The scores of performance IQ and full scale IQ were significantly higher after the surgery than those before the surgery in all the patients including the patients undergoing left and right SAH (P<0.05). The visual memory was improved a little after the surgery compared with that before surgery in all the patients. The verbal memory scores were significantly lower after the surgery than those before the surgery in the patients undergoing left SAH (P<0.05). Conclusion Left SAH may have a detrimental effect on verbal memory and language ability in the patients with MTLE.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目：全军后勤科研计划（CNJ14J008） 作者单位：350025 福州，福建医科大学福总临床医学院（福州总医院）神经外科癫痫中心（贾延增、杨朋范、林　巧、裴家生、陈其钻、钟忠辉） 通讯作者：杨朋范，E-mail：neurosurg.yang@163.com
更新日期/Last Update: 2018-11-20