[1]罗　斌　苗素华　何　乐　赵亚鹏　徐成伟　朱　晋　张庆辉　张玉琪.儿童鞍区肿瘤的视觉传导通路DTI特征分析[J].中国临床神经外科杂志,2019,(03):129-131.[doi:10.13798/j.issn.1009-153X.2019.03.001]
　LUO Bin,MIAO Su-hua,HE Le,et al.Study of visual conduction pathway by DTI in 24 children with sellar tumors[J].,2019,(03):129-131.[doi:10.13798/j.issn.1009-153X.2019.03.001]
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儿童鞍区肿瘤的视觉传导通路DTI特征分析()
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《中国临床神经外科杂志》[ISSN:1009-153X/CN:42-1603/TN]

卷:
期数:
2019年03期
页码:
129-131
栏目:
论著
出版日期:
2019-03-20

文章信息/Info

Title:
Study of visual conduction pathway by DTI in 24 children with sellar tumors
文章编号:
1009-153X（2019）03-0129-03
作者:
罗　斌　苗素华　何　乐　赵亚鹏　徐成伟　朱　晋　张庆辉　张玉琪
作者单位：100049 北京，清华大学玉泉医院神经外科（罗　斌、苗素华、赵亚鹏、徐成伟、朱　晋、张庆辉、张玉琪）；100084 北京，清华大学生物医学影像研究中心（何　乐）
Author(s):
LUO Bin1;  MIAO Su-hua1;  HE Le2;  ZHAO Ya-peng1;  XU Cheng-wei1;  ZHU Jin1;  ZHANG Qing-hui1;  ZHANG Yu-qi1.
1. Department of Neurology, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing 100049, China; 2. Center for Bio- Medical Imaging Research, Tsinghua University, Beijing 100084, China
关键词:
颅内肿瘤; 鞍区肿瘤; 儿童; 磁共振弥散张量成像; 弥散张量纤维束成像
Keywords:
Children;  Sellar tumors;  MR diffusion tensor imaging;  Optic chiasm injury
分类号:
R 739.41; R 445.2
DOI:
10.13798/j.issn.1009-153X.2019.03.001
文献标志码:
A
摘要:
目的 应用磁共振弥散张量成像（DTI）和弥散张量纤维束成像（DTT）评估儿童鞍区肿瘤的视神经受损情况。方法 对24例儿童鞍区肿瘤（其中视交叉胶质瘤12例、鞍区颅咽管瘤7例、三脑室畸胎瘤2例、下丘脑错构瘤2例、斜坡脊索瘤1例）病例进行DTI和DTT检查，计算双侧视神经的部分各向异性（FA）值，并进行统计学分析。结果 根据显示的视交叉位置形态以及与肿瘤的空间结构关系，24例患儿可分为视交叉破坏组（12例）和视交叉压迫组（12例）。破坏组双侧视神经FA值均明显低于压迫组（P<0.05）。结论 DTI和DTT检查可以清晰的显示儿童鞍区肿瘤与视路神经纤维束的空间关系，其获得的参数FA值可以用来评价视路损伤的性质和程度。
Abstract:
Objective To assess visual impairment by MR diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in children with sellar tumors. Methods DTI and DTT imaging were performed, and the fractional anisotropy (FA) values of the bilateral optic nerves were calculated and statistically analyzed in 24 children with sellar tumors (including 12 optic chiasm gliomas, 7 sellar craniopharyngiomas, 2 teratomas in the third ventricles, 2 hypothalamic hamartomas, and 1 clivus chordoma. Results The optic chiasms were destroyed by the tumors in 12 children with sellar tumors and were compressed by the tumors in 12 children with sellar tumors according to the locations and shapes of the optic chiasms and their spatial relationships with the tumors. The FA values of the bilateral optic nerves were significantly lower in 12 children with destroyed optic chiasms than those in 12 children with the compressed optic chiasms (P<0.05). Conclusions DTI and DTT imaging examination can clearly show the spatial relationship between sellar tumors and visual nerve fiber bundles in children with sellar tumors. The obtained FA values can be used to evaluate the nature and degree of damage to the optic nerve and visual pathway by the tumors.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（81470048）
作者单位：100049 北京，清华大学玉泉医院神经外科（罗斌、苗素 华、赵亚鹏、徐成伟、朱晋、张庆辉、张玉琪）；100084 北京，清华大 学生物医学影像研究中心（何乐）
通讯作者：张玉琪，E-mail：yuqi9597@sina.com
更新日期/Last Update: 2019-03-25